Contents
ʻO nā hopena o kahi loiloi biochemical, e hōʻike ana i ke kiʻekiʻe o ka cholesterol i ke koko, e ʻae i ka loea e kuhikuhi i nā lāʻau kūpono. Manaʻo pinepine ʻia nā statins e pale i nā pilikia naʻau i kēia hihia.
ʻO ka maʻamau, ʻo ke kauka hele, e kuhikuhi ana i kēlā mau kālā, e aʻo koke i ka mea maʻi e lawe ʻia me ka hoʻomaha ʻole. Eia kekahi, e like me nā lāʻau lapaʻau ʻē aʻe, loaʻa nā statins i nā hopena ʻaoʻao i ke kino. Pono ka mea maʻi e wehewehe i kēia wahi i ka manawa i hui pū me kāna kauka. Ma hope o nā mea a pau, ʻo ka hana nui me ka cholesterol kiʻekiʻe e hoʻemi i kona pae. Loaʻa ka hopena me ke kōkua o ka lāʻau lapaʻau. Eia naʻe, pono e hoʻomaka nā lāʻau lapaʻau i nā hihia a pau? E loaʻa anei ka hopena i makemake ʻia me kā lākou kōkua?
ʻO ke ʻano o ka hui o fibrates a i ʻole statins haʻahaʻa i ka cholesterol. Hiki iā ʻoe ke hoʻonui i kā lākou hopena ma ka lawe ʻana i ka lipoic acid a me ka Omega-3 fatty acids. Kuhi ʻia kēia ʻatikala i nā lāʻau lapaʻau e hōʻemi i ka cholesterol, nā hiʻohiʻona o kā lākou hoʻohana a me nā hopena ʻaoʻao.
Hoʻohaʻahaʻa i ka Cholesterol me nā Statins
Aia ka pūʻulu pharmacological o statins i nā lāʻau lapaʻau nona ka pahuhopu nui e hōʻemi i ka hoʻokuʻu ʻana o nā enzyme kikoʻī i komo i ka synthesis o ka cholesterol.
I ka wehewehe ʻana i kēia mau lāʻau lapaʻau a me nā papa, hāʻawi ʻia nā waiwai i lalo:
Hana lākou ma ke ʻano he mea pale i ka HMG-CoA reductase, no laila e hoʻohaʻahaʻa i ka cholesterol, e hōʻemi ana i kāna hana;
Hana lākou ma ke alo o nā lāʻau lapaʻau maʻamau. No ka laʻana, ʻaʻole pili ka hypercholesterolemia ʻohana homozygous i ka hopena o nā statins;
Loaʻa ka hopena maikaʻi i ka puʻuwai puʻuwai, e hōʻemi ana i ka hiki ke hoʻouka ʻia ka naʻau a me ka angina pectoris;
Ma hope o ka lawe ʻana i nā lāʻau lapaʻau, hoʻonui ka HDL-cholesterol a me apolipoproteinA i ke koko;
ʻAʻole like me nā lāʻau lapaʻau ʻē aʻe, ʻaʻole mutagenic a i ʻole carcinogenic nā statins.
ʻAʻole pono nā lāʻau lapaʻau i ke kino i nā manawa a pau. Hiki i nā statins ke hana i nā hopena ʻaoʻao aʻe:
ʻO ka hiamoe, ke poʻo poʻo, ka nausea, ka ʻōpū, ka myalgia;
Amnesia, malaise, hypesthesia, neuropathy, paresthesia;
ʻO ka hōʻoluʻolu i nā ʻiʻo o ke kua, nā wāwae, myopathy, convulsions;
luaʻi, anorexia, cholestatic jaundice;
ʻO kahi hopena maʻi, hōʻike ʻia e ka ʻili ʻili a me ka ʻili, urticaria, anaphylaxis, exudative erythema;
ʻO kahi hāʻule o ke kō koko, e kōkua ana i ka ulu ʻana o ka maʻi diabetes a me ka hypoglycemia;
Loaʻa i ke kaumaha nui;
ka ulu ʻana o ka maʻi ʻole.
I ka manawa hea e pono ai nā statins?
ʻO ka wehewehe ʻana o ka hapa nui o nā statins i loaʻa ka ʻike e hōʻike ana i nā waiwai pono o nā lāʻau lapaʻau. Hoʻemi i ka pilikia o ka maʻi puʻuwai, hoʻomaʻamaʻa i nā pae cholesterol, pale i ka hōʻeha ʻana o ka naʻau - ua hāʻawi ʻia kēia mau hopena āpau e ke ala o kēia pūʻulu pharmacological, e like me nā hui hoʻolaha. Eia naʻe, ʻo kēia ka hihia? Ma hope o nā mea a pau, he kiʻekiʻe ke kumukūʻai o ia mau lāʻau lapaʻau, no laila, ʻo ka ʻike e pili ana i nā pono o nā statins kahi hoʻāʻo e huki i nā mea kūʻai? He maikaʻi maoli lākou no ke olakino?
ʻOiai nā hopena o nā haʻawina e hōʻike ana i ka nele o nā hopena maikaʻi ʻole o nā lāʻau lapaʻau i ke kino o ke kanaka, hiki i nā poʻe loea ke hilinaʻi hilinaʻi i nā statins no ke komo ʻana. Heʻoiaʻiʻo kēia no nā poʻe maʻi kahiko. Ma ka ʻaoʻao hoʻokahi, ua hōʻike nā hoʻokolohua e kōkua ka lāʻau lapaʻau me nā statins i ka hoʻohaʻahaʻa ʻana i ka cholesterol. Mālama pū lākou i kekahi mau maʻi koʻikoʻi. Akā ʻokoʻa ka manaʻo o ka poʻe loea, manaʻoʻiʻo e pili ana ka hopena maikaʻi o nā statins me kahi pilikia kiʻekiʻe. He kiʻekiʻe loa ka hopena o nā hopena ʻaoʻao, he mea weliweli loa ia no nā poʻe maʻi ʻelemakule.
I ka manawa like, ua kauoha ʻia nā lāʻau lapaʻau o kēia hui i nā hihia aʻe:
ʻO ka manawa hea e mālama ʻia ai ka pale ʻana i nā maʻi me ka puʻuwai a i ʻole ka hahau ʻana;
Me ka maʻi ischemic me ka hoʻoweliweli o ka hoʻomohala ʻana i nā pilikia like ʻole;
Me ka maʻi coronary a i ʻole ka puʻuwai puʻuwai;
Hoʻopili pū ʻia ka ʻoki ʻana i ke ʻano o ka coronary artery bypass i ka lawe ʻana i nā statins.
ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i nā statins i mua o ka maʻi diabetes mellitus, a me nā wahine ʻaʻole i hiki i ka makahiki menopausal. ʻAʻohe pono e lawe i nā lāʻau lapaʻau inā hiki ke loaʻa nā lāʻau lapaʻau ʻē aʻe e pale aku i nā hopena ʻaoʻao.
Hāʻawi nā lāʻau lapaʻau Lūkini e hoʻohana i kēia mau statins me nā hana like ʻole:
ʻO Rosuvastatin: Acorta, Crestor, Mertenil, Rosuvastatin, Rosucard, Rosulip, Roxera, Tevastor
Lovastatin: Cardiostatin, Choletar, Cardiostatin
Atorvastatin: Atomax, Atorvastatin Canon, Atoris, Liprimar, Torvacard, Tulip, Liptonorm
Fluvastatin: Leskol Forte
Simvastatin: Vasilip, Zokor, Ovencor, Simvagexal, Simvakard, Simvastatin, Simvastol, Simvor, Simgal, Simlo, Sinkard
Loaʻa nā lāʻau lapaʻau ma nā ʻano like ʻole, ʻokoʻa hoʻi ko lākou kumukūʻai.
Pehea e koho ai i nā statins?
Pono ka mea maʻi e hoʻoholo nona iho inā e lawe i nā statins. I kēia hihia, pono ʻoe e kamaʻilio mua me kahi loea kūpono, inā pono, e kuhikuhi i kahi lāʻau lapaʻau kūikawā. ʻAʻole ʻōlelo ʻia e hana i kekahi hana me ke kōkua ʻole o ke kauka. Inā hōʻike ʻia kahi hōʻike koko biochemical i ka hele ʻana o nā mea ʻino, pono ʻoe e kipa i kahi lapaʻau a me kahi endocrinologist. ʻOiaʻiʻo, ke koho ʻana i nā statins, ke kau nei ke kauka i ke kāne, ka makahiki a me ke kaumaha o ka mea maʻi, e noʻonoʻo ana inā he mau maʻi ʻino a me nā maʻi maʻi.
I ka wā o ka mālama ʻana, pono ia e pili i ka dosage i hoʻokumu ʻia e ka loea, e hana mau i nā hoʻokolohua. Inā ʻaʻole i loaʻa kahi lāʻau lapaʻau i lawe ʻia e ke kauka ma muli o ke kumukūʻai kiʻekiʻe, ʻo ia ka mea maʻamau no ka hapa nui o nā statins, hiki iā ʻoe ke loaʻa i kahi analogue home kūpono. ʻOiai e pili ana kēia i ka pono o ka mea hana.
He mea nui e hoʻomanaʻo i ka palekana o ka lawe ʻana i nā haʻahaʻa haʻahaʻa o rosuvastatin i nā pathologies ate mau, hiki ke hoʻololi ʻia e pravastatin. ʻAʻole hiki iā ʻoe ke hoʻohui i nā lāʻau lapaʻau me ka waiʻona a i ʻole nā antibiotics. ʻO kahi pōmaikaʻi koʻikoʻi o ka pravastatin ʻo ia hoʻi kona haʻahaʻa haʻahaʻa, ʻo ia ke kumu i hōʻike ʻia ai no nā poʻe maʻi me ka ʻehaʻeha. ʻO ka hiki ke hoʻohui pū i nā statins a me ka waikawa nicotinic he mea hoʻopaʻapaʻa. Aia kekahi manaʻo e hiki i kēia ke hoʻonui i nā maʻi maʻi.
No ke aha e pilikia ai nā statins?
I Rusia, ua kuhikuhi ikaika ʻia nā lāʻau lapaʻau ma hope o nā kauka ʻAmelika. ʻO ka maʻi Ischemic, arterial hypertension - ua mālama ʻia kēia mau maʻi āpau me nā statins. I kēia hihia, ua hoʻohana ʻia nā dosages nui. Eia nō naʻe, ma ʻAmelika Hui Pū ʻIa, ua hana koke ʻia kahi noiʻi e hōʻoia i ka pilina ma waena o ka ulu ʻana o nā maʻi he nui a me ka hoʻohana ʻana i nā statins. Ma 2013, ua paʻi ka British Medical Journal i ka ʻike e pili ana i kā lākou hopena ʻino i ke olakino o nā maʻi. Akā ʻaʻohe haʻawina kūʻokoʻa ma Rūsia, a hoʻomau ka poʻe loea i ka hoʻohana ikaika ʻana i nā lāʻau lapaʻau o kēia hui.
Ma Kanada, ua ʻike ʻia ua ʻike pinepine nā poʻe maʻi ʻelemakule e lawe ana iā lākou i ka wikiwiki o ka ʻike a me ka ulu ʻana o nā cataracts. Piʻi nui ka pilikia i mua o ka maʻi diabetes.
Ke kānalua nei kekahi mau ʻike i nā pono o nā statins:
Hiki i nā lāʻau lapaʻau ke hoʻopilikia i ka cholesterol ma lalo o ka maʻamau, ʻoi aku ka pōʻino ma mua o ka nui. Hiki iā ia ke hoʻoulu i nā maʻi maʻi ʻino, ka maʻi ate, ka anemia, ka hahau, ka pepehi kanaka a me ke kaumaha.
Hoʻopilikia nā statins i ka hana hoʻihoʻi o ka cholesterol. Mahalo i ka cholesterol, hoʻopau ʻia ka pōʻino i ke kino. ʻO kēia ma muli o ka ʻoiaʻiʻo ʻo ia kekahi o nā mea koʻikoʻi loa i ka haku ʻana o ka ʻiʻo scar. Eia kekahi, he mea koʻikoʻi ka cholesterol maikaʻi ʻole no ka ulu ʻana o ka ʻiʻo a me ke kino holoʻokoʻa. ʻO kona hemahema ke kumu e ʻeha ai ka ʻiʻo a me ka dystrophy.
ʻO ka nele o ka Magnesium, ʻaʻole ka nui o ka cholesterol, ke alakaʻi nei i ka hahau a me ka hōʻeha puʻuwai. Ke kānalua nei kēia hypothesis i ka pono o ka hoʻohana ʻana i nā statins.
Me ka emi ʻana o nā pae cholesterol, hoʻemi ʻia ka synthesis o nā mea nui ʻē aʻe i ke kino. Pili kēia i ka pūhui e like me ka melovanate. Hoʻopili ia i nā hana biological he nui, me ka hoʻokumu ʻana o ka cholesterol.
ʻO ka hana o nā statins e hoʻonāukiuki i ka maʻi diabetes mellitus, ka mea e hoʻopilikia maikaʻi ʻole i ka hana ʻana o ka cholesterol a kōkua i ka hiki ʻana o nā maʻi ʻē aʻe. ʻO kēia kumu, e like me nā mea noiʻi ma Kelemānia, ke kumu o ka angina pectoris a me ka arrhythmia, ka hahau. Loaʻa kēia ma muli o ka emi ʻana o ka neʻe ʻana o kahi protein e pili ana i ke kiʻekiʻe o ke kō koko. Wahi a nā hopena noiʻi, pilikia nā wahine i ka makahiki menopausal.
Aia nā pilikia ma ka lolo ma muli o ka lawe lāʻau. ʻO ka mea mua, pili nā statins i ka metabolism cholesterol, e pili ana i ka hana o ke ake. I ka manawa like, he hopena maikaʻi nā lāʻau lapaʻau i nā kīʻaha koko. Eia nō naʻe, ʻo ka hopena o nā kemika he mea pōʻino i ke kino. ʻO ka hopena, hiki ke hoʻololi ʻia i nā kaʻina hana physiological, me ka hana noʻonoʻo hiki ke hoʻopilikia ʻia.
ʻIke pinepine ʻia nā hopena ʻaoʻao o nā statins.
ʻO kekahi poʻe ʻepekema, e noʻonoʻo ana i ka cholesterol kiʻekiʻe e like me ka hōʻoia ʻana o ka hele ʻana o nā maʻi koʻikoʻi, e hōʻike ana i ke kaumaha a me nā mumū ʻē aʻe ke kumu o nā pathologies cardiac. Ua lōʻihi ka hoʻolaha ʻana o kekahi mau ʻāina i ke ola olakino i mea e pale ai i nā pilikia i ka hana o ka puʻuwai. Mahalo i kēia, ua emi ka nui o nā mea maʻi me nā pathologies, kahi i hōʻike ʻia e hiki ke hoʻomaʻamaʻa ʻia ka cholesterol ma ka haʻalele ʻana i nā hana maikaʻi ʻole a koho i nā haʻuki a me ka meaʻai kūpono. No laila, ʻo ke ola olakino e ʻae iā ʻoe e pale i ka lawe ʻana i nā lāʻau lapaʻau i loaʻa ka nui o nā hopena ʻaoʻao, a pale i ka hoʻomohala ʻana o nā pathologies pōʻino.
ʻO kekahi kumu maikaʻi ʻole mai ka lawe ʻana i nā statins
Wahi a kahi noiʻi o 3070 poʻe ma mua o 60 mau makahiki, ʻo ka hoʻohana ʻana i ka statin e hoʻoulu ai i ka ʻeha o ka ʻiʻo ma 30% o nā kānaka, e kaupalena ana i kā lākou hana kino. ʻO ka hopena o ka hoʻonui ʻana i ka ʻeha i loko o nā ʻiʻo, hōʻole ka poʻe maʻi i ka pāʻani haʻuki, hele liʻiliʻi. Ke alakaʻi nei kēia mau mea a pau i ke kaumaha a hoʻonui i ka pilikia o ka maʻi puʻuwai.
Kōkua nā Fibrates e hoʻohaʻahaʻa i ka cholesterol
Hoʻohana pinepine ʻia nā derivatives fibroic acid i kapa ʻia ʻo fibrates ma ke ʻano he koho i nā statins. Hana pololei lākou i ke ake, e hōʻemi ana i kāna excretion o ka cholesterol. Hoʻopilikia pū ka Fibrates i ka nui o nā lipid, e hōʻemi i ka hoʻokumu ʻana o nā waihona extravascular. Ma hope o ka lawe ʻana i kēia mau lāʻau lapaʻau, ua maʻamau ka pae o ka cholesterol maikaʻi a maikaʻi ʻole.
Me nā hopena maikaʻi, he hopena maikaʻi ʻole ka fibrates, i hōʻike ʻia ma ke ʻano o:
ʻO ka maʻi hepatitis, ka pancreatitis, ka maʻi maʻi, nausea, luaʻi, ʻeha i ka ʻōnaehana digestive;
ʻO ka thromboembolism venous, pulmonary embolism;
ʻO ka nāwaliwali o ka ʻiʻo a me ka spasms, diffuse myalgia;
ke poʻo, ka moe kolohe;
ʻO ka māmā māmā a me nā hopena maʻi.
Hoʻohana pinepine ʻia ka mālama paʻakikī, e pili ana i ka hui pū ʻana o nā fibrates a me nā statins. No laila, hiki ke hoʻemi i ka dosage o ka hope.
Hōʻike ʻia nā fibrates e ʻekolu mau hanauna:
Clofibrate - ka fibrate kahiko o ka hanauna 1, ʻaʻole i hoʻohana hou ʻia, no ka mea, ua hōʻike ʻia ua kōkua ia i ke ʻano o ka oncology;
ʻO Gemfibrozil, bezafibrate - ua like loa ke ʻano me ka clorifibrate, akā ʻoi aku ka liʻiliʻi o ka ʻona. Ua manaʻo ʻia hoʻi he kahiko, ʻaʻole i hoʻohana ʻia i kēia manawa;
Fenofibrate, Ciprofibrate - no ka hanauna 3 o nā fibrates, ʻo ia ka mea kaulana loa. Ma waho aʻe o ka hoʻohaʻahaʻa ʻana i ka cholesterol, hoʻemi ia i ke kiʻekiʻe o ka uric acid, a hōʻemi hoʻi i ka hopena o nā pilikia o ka maʻi diabetes. Kūʻai ʻia ma lalo o nā inoa kālepa Traykor (Palani), Lipantil 200 M (Palani), Fenofibrate Canon (Rūsia), Exlip (Turkey).
Hoʻemi ʻia ka ʻai ʻana o ka cholesterol
ʻO ka hapa nui o nā koi o kēlā me kēia lā no ka cholesterol e hoʻokō ʻia e ke kino, hoʻopiha ʻia ke koena ma o ka meaʻai.
ʻO ka normalization o nā pae cholesterol me nā hoʻomākaukau kūlohelohe
Manaʻo nā kauka he nui ma mua o nā statins a me nā fibrates e hoʻohaʻahaʻa i ka pae cholesterol me kēia mau ʻano:
ʻO nā waikawa momona Omega-3. Loaʻa iā lākou ma ka nui o ka aila iʻa a me ka aila flaxseed, a lawelawe ma ke ʻano he prophylactic e kūʻē i ka hahau ʻana, nā maʻi hopohopo, a me ka ʻāʻī. I ka manawa like, ʻaʻole pono e hōʻino ʻia ke ʻano o ka aila iʻa, no ka mea hiki ke hoʻonui i ka pancreatitis.
ʻUmeke. ʻO kēia lāʻau lapaʻau maoli ʻo ia ka ʻaila hua paukena. Hoʻohana ʻia e pale i ka atherosclerosis o nā moku cerebral, hepatitis, cholecystitis, he anti-inflammatory, hepatoprotective, choleretic a me nā hopena antioxidant.
Lipoic acid. Kāohi ia i ka atherosclerosis coronary, kahi hopena i ke kiʻekiʻe o ka glycogen i loko o ke ake. Me ke kōkua o ka lipoic acid, hiki ke hoʻomaikaʻi ʻia ka trophism neuronal.
ʻO ka lāʻau lapaʻau vitamina. ʻO ke kumu maikaʻi loa o nā mea e pono ai no ke kino nā huahana kūlohelohe i waiwai i ka nicotinic a me ka folic acid, nā huaora B3, B6, B12.
dietary kumukanawai a No kēia mau mea, pono ke hoʻohana ʻana iā SitoPren - fir foot extract. Loaʻa iā ia ka beta-sitosterol, ʻo ia hoʻi nā polyprenols, pono no ka atherosclerosis, diabetes.