Vitamin B9

Nā waiwai kūpono a me nā hopena ma ke kino

Nā keu pono o ka wikamina B9 no ke kino:

• pili i ka papa o kahi hāpai olakino olakino a me ka ulu pono ʻana o ka ʻōpū: folic acid ālai i ka hoʻomohala ʻana o nā hemahema i loko o ka ʻōnaehana ʻōiwi o ka pēpē, kaona paona ʻole, hānau mua ʻole, a kū kēia i nā wā mua o ka hāpai ʻana.
• antidepressant: manaʻo ʻia ʻo folic acid e kōkua i ka mālama ʻana i ke kaumaha a hoʻomaikaʻi i ke olakino maikaʻi.
• kōkua i ka protein pūnao.
• Kūʻē: ʻO ka Vitamin B9 i manaʻo ʻia he antioxidant ikaika e kōkua i ka holoi ʻana i nā toxins mai ke kino a hoʻomaikaʻi i ke ʻano o ka ʻili.
• Mālama i ke olakino puʻuwai: ʻo ka ʻai ʻana i ka waikawa folic e hoʻohaʻahaʻa ai i nā pae homocysteine ​​koko, i hiki ke hoʻokiʻekiʻe ʻia a hiki ke hoʻokau iā ʻoe i ka maʻi puʻuwai. Eia kekahi, ʻo ka paʻakikī o nā huaʻai B, i komo pū me ka waikawa folic, hoʻemi i ka makaʻu o ka ulu ʻana.
• Ke hōʻemi nei i ka makaʻu o ka maʻi ʻaʻai: Aia kekahi hōʻike e pili ana ka lawa ʻole o ka lawe ʻana i ka folate me ka ulu ʻana o ka maʻi ʻaʻai umauma i nā wahine.

ʻO ka Folic acid metabolism i loko o ke kino

ʻO ka hana a Folate ma ke ʻano he coenzyme i loko o ka synthetic acid synthetic a me ka amino acid metabolism. I ka manawa i ke kino, hydrolyzed ka folates papaʻai i ke ʻano o monoglutamate i loko o ka ʻōpū ma mua o ka lawe ʻia ʻana e nā mea lawe i loko o ka membrane mucous. Ma mua o ke komo ʻana i ke kahe o ke koko, hoʻemi ʻia ka palapala monoglutamate i tetrahydrofolate (THF) a hoʻohuli ʻia i ka methyl a i ʻole formyl form. ʻO ka kumu nui o ka folate i ka plasma ʻo 5-methyl-THF. Hiki ke loaʻa pū kekahi ka waikawa folic i hoʻololi ʻole ʻia i loko o ke koko (unmetabolized folic acid), akā ʻaʻole ia i ʻike inā he hana maoli kā kēia palapala.

I mea e hele ai ka folate a me kāna mau coenzymes i nā membrane pūnaewele, koi ʻia nā halihali kūikawā. Hoʻopili kēia i ka lawe folate folate (RFC), proton hui pū ʻia ʻo folate (PCFT), a me nā protein receptor folate, FRα a me FRβ. Kākoʻo ʻia ʻo Folate homeostasis e ka hoʻolaha ākea o nā mea lawe folate, ʻoiai he ʻokoʻa ka helu a me ka nui o nā kino like ʻole o ke kino. He mea nui ko PCFT i ke kanu ʻana i ka folate no ka mea ʻo ka mutation e hoʻopili ana i ka genode hoʻopunipuni ʻana ʻo PCFT ke kumu o ka malabsorption folate hereditary. Loaʻa nā hemahema PCFT i ka lawe ʻole ʻia o folate i ka lolo. He mea koʻikoʻi ʻo FRa a me RFC no ka lawe ʻana i ka folate ma o ka pale i waena o ka ʻōnaehana kahe a me ka ʻōnaehana waena. Pono ka Folate no ka hoʻomohala pono ʻana o ka embryo a me ka fetus. ʻIke ʻia ke kuleana o ka placenta no ka hoʻokuʻu ʻana o ka folate i loko o ka pēpē, a laila ʻoi aku ka nui o nā folate i loko o ka pēpē ma mua o ka makuahine. Pili nā ʻano ʻekolu i nā lawe ʻana i ka folate ma waena o ka placenta i ka wā hāpai.

Hana pū me nā micronutrients ʻē aʻe

Hoʻokumu ʻia ka folate a hui pū kekahi o nā pālua micronutrient ikaika loa. Kākoʻo kā lākou launa pū ʻana i kekahi o nā kaʻina kumu nui o ka mahele cell a me ka hana hou ʻana. Eia kekahi, komo pū lākou i ka metabolism o ka homocysteine. ʻOiai hiki ke loaʻa maoli kēia mau huaora ʻelua mai nā ʻano meaʻai like ʻole ʻelua (vitamin B12 - mai nā huahana holoholona: ka ʻiʻo, ka ate, nā hua manu, ka waiū, a me ka huaora B9 - mai nā lau lau, nā pī), he mea nui ko lākou pilina. no ke kino. Hana lākou ma ke ʻano he cofactor i ka synthesis o ka methionine mai homocysteine. Inā ʻaʻole hiki ke synthesis, a laila hiki ke hoʻokiʻekiʻe ʻia ke kiʻekiʻe o ka homocysteine ​​​​, i pili pinepine ʻia me ka pilikia o ka maʻi cardiovascular a me ka hahau.

Kū kekahi pilina pilikino me ka nui i loko o ka huaʻai B9 me riboflavin (). ʻO ka hope kahi mua o kahi coenzyme e pili ana i ka folate metabolism. Hoʻololi ia i ka folate i kona ʻano hana, 5-methyltetrahydrofolate.

e kaupalena i ka hoʻohaʻahaʻa o nā coenzymes folate maoli a me ka acidic folic supplemental i loko o ka ʻōpū a hoʻomaikaʻi i ka bioavailability folate.

ʻO nā hui kūpono o nā meaʻai me ka huaʻai B9

Pono ka Vitamin B9 e hoʻohui me nā huaora B ʻē aʻe.

ʻO kahi laʻana, i ka salakeke me ka kale, nā hua pua pua lā, ka feta, ka bale, ka ʻakaʻula, nā pīpī, nā avocado, a me nā lole lemon. ʻO kēlā salakeke e hāʻawi i ke kino me nā huaora B3, B6, B7, B2, B12, B5, B9.

ʻO kahi ʻaina kakahiaka maikaʻi a i ʻole ʻaina awakea māmā kahi sandwich i hana ʻia mai ka palaoa palaoa, salmon puhi ʻia, asparagus, a me nā hua hua moa. Loaʻa i kēia meaʻai nā wikamina e like me B3 a me B12, B2, B1 a me B9.

ʻO ka meaʻai ke kumu maikaʻi o nā wikamina. No laila, pono e noʻonoʻo ʻia ka hiki ke lawe i nā wikamina i ke ʻano o nā lāʻau inā loaʻa nā hōʻailona kūpono. Aia kekahi hōʻike e hoʻomākaukau nā huaora, inā hoʻohana hewa ʻia, ʻaʻole wale ia e pōmaikaʻi ai, akā hiki nō hoʻi ke hōʻeha i ke kino.

Hoʻohana i ka lāʻau kūhelu

hāpai keiki

Hoʻohana ʻia ʻo Folic acid i ka lāʻau no nā kumu he nui. ʻO ka mea mua, ua kau ʻia no nā wahine hāpai a me nā mea e hoʻomākaukau ana no ka hāpai ʻana. Hoʻohālikelike ʻia ka ulu a me ka hoʻomohala ʻana o ka fetus e ka mahele o ka pūnaewele paʻa. Kūpono nā pae folate lawa no ka synthes DNA a me RNA. Ma muli o ka nele o ka folic acid, ma waena o ka 21 a me ka 27 mau lā ma hope o ka hapai ʻana, ua kāhea ʻia kahi maʻi kīnā neural tube… Ma ke ʻano he kūlana, i kēia wā, ʻaʻole ʻike ka wahine ua hāpai ʻo ia a ʻaʻole hiki ke hana i nā ana kūpono e ka hoʻonui ʻana i ka nui o ka folate i ka papaʻai. Ke alakaʻi nei kēia maʻi i ka hopena o nā hopena i makemake ʻole ʻia no ka ʻōpū - hōʻino lolo, encephalocele, ʻeha leʻa.

ʻO nā anomalies puʻuwai congenital kahi kumu nui o ka make i nā keiki a hiki ke alakaʻi i ka make i ka wā makua. Wahi a ka European Registry of Congenital Anomalies a me Gemini, e ʻai ana ma ka liʻiliʻi he 400 mcg o ka folic acid i kēlā me kēia lā i hoʻokahi mahina ma mua o ka hapai ʻana a no 8 mau pule ma hope iho ua hoʻēmi i ka makaʻu o ka naʻau congenital e 18 pākēneka.

Hiki paha i nā pae folate makuahine ke hoʻohuli i ka makaʻu o ka hoʻomohala ʻana i nā kīnā ʻole o ka palate congenital cleft. Ua hōʻike ʻia ka noiʻi ma Nolewai i ka lawe ʻana i kahi huamini kō me ka hapa 400 mcg o folate i hoʻemi ʻia ka maka o ka hāleo e 64%.

Hoʻopili ʻia ke kaumaha o ka hānau haʻahaʻa me ka hoʻonui ʻana o ka make i ka makahiki mua o ke ola a hiki paha ke hoʻopili i ke kūlana olakino i ka wā makua. ʻO kahi loiloi ʻōnaehana hou a me nā meta-analysis o nā noiʻi ʻewalu i kāohi ʻia i hōʻike i kahi hui maikaʻi ma waena o ka lawe ʻana o folate a me ka hānau hānau.

ʻO nā kiʻekiʻe o ke kiʻekiʻe o ke koko o ka homocysteine ​​ua pili pū ʻia me ka hoʻonui ʻia o nā miscarriages a me nā pilikia ʻē aʻe o ka hāpai ʻana, e like me preeclampsia a me ka abruption placental. Ua hōʻike ʻia kahi noiʻi retrospective nui i ka pae o ka homosisteine ​​plasma i nā wahine i hoʻohuli pololei i ke kū ʻana o nā hopena hāpai hāpai ʻole a me nā pilikia, e like me ka preeclampsia, ka hana mua, a me ka kaumaha hānau haʻahaʻa loa. ʻO ke kānāwai o ka homocysteine, a laila, kū pū me ke komo ʻana o ka folic acid.

No laila, he akahele e lawe i ka waikawa folic, ma lalo o ka mākaʻi a ke kauka, ma loko o ka hāpai ʻana, ʻoiai ma hope o ka pani ʻia ʻana o ka neural tube, e hōʻemi ai i ka pilikia o nā pilikia ʻē aʻe i ka wā hāpai. ʻO ka mea hou aku, ʻaʻole i ʻike ʻia nā noiʻi hou o kahi hui ma waena o ka lawe ʻana o folate i ka wā hāpai a me nā hopena olakino maikaʻi ʻole i nā keiki, i ka ulu ʻana o ka I.

ʻO nā maʻi maʻi cardiovascular

Hōʻike nā haʻawina he 80 a ʻoi aku ke kiʻekiʻe o ke kiʻekiʻe o ke koko o ka homocysteine ​​e hoʻonui ai i ka makaʻi o ka maʻi maʻi ʻōpū. ʻO ke ʻano e hoʻonui ai ka homocysteine ​​i ka makaʻu o ka maʻi vaskular ke kumuhana o ka noiʻi, akā hiki ke hoʻopili ʻia i nā hopena maikaʻi ʻole o ka homocysteine ​​ma ke kāpili ʻana i ke koko, ka vasodilation arterial, a me ka mānoanoa o nā paia arterial. Ua hoʻopili ʻia nā papaʻai waiwai Folate i ka hoʻemi ʻia o nā maʻi puʻuwai, e like me ka myocardial (hōʻeha puʻuwai) a me ka hahau. ʻO kahi noiʻi o nā kāne 1980 ma Finilana ma kahi o 10 mau makahiki i ʻike ʻia ʻo ka poʻe i ʻai i ka nui o ka papaʻai folate i loaʻa kahi 55% haʻahaʻa o ka maʻi puʻuwai hikiwawe ke hoʻohālikelike ʻia me ka poʻe i ʻai i ka folate liʻiliʻi loa. I loko o nā huaʻai B ʻekolu e hoʻoponopono ai i ka hoʻoliʻiliʻi homositistine, ua hōʻike ʻia ka hopena ʻoi loa ka hopena o ka hoʻohaʻahaʻa basal concentrations, ke loaʻa ʻole ka vitamina B12 a i ʻole ka hapa B6. ʻO ka hoʻonui ʻana i ka ʻai folate mai nā meaʻai waiwai folate a i ʻole nā ​​mea hoʻopihapiha i loaʻa e hōʻemi ai i nā kukuna homocysteine.

ʻOiai ka hoʻopaʻapaʻa e pili ana i ke kuleana o ka hoʻohaʻahaʻa ʻana i ka homocysteine ​​i ka pale ʻana i ka maʻi maʻi maʻi o ka maʻi, ua nānā ʻia kekahi mau noiʻi i nā hopena ulu o ka folate supplementation, kahi ʻike pilikia no ka maʻi vascular. ʻOiai ʻaʻole i hōʻike ʻia nā hoʻokolohua hou e pale pono ana ʻo folate i ke kino, ʻo ka ʻai folate haʻahaʻa kahi mea ʻike ʻia no ka maʻi puʻuwai.

Cancer

Kuhi ʻia ka maʻi ʻaʻai e ka hōʻino ʻia o DNA ma muli o ka nui o nā hana hoʻoponopono DNA, a i ʻole e ka hōʻike kūpono ʻole o nā gen key. Ma muli o ke kuleana nui o folate i loko o ka synthes DNA a me RNA, hiki i ka lawa ʻole o ka lawe ʻia ʻana o ka wikamina B9 ke kōkua i ka genome instability a me nā chromosome kīnā e pili pinepine ʻia me ka ulu ʻana o ka maʻi ʻaʻai. Eia kekahi, koʻikoʻi ka hoʻopiʻi ʻana a DNA a me ka hoʻoponopono ʻana i ka mālama ʻana i ka genome, a ʻo ka nele o nā nucleotides i hoʻokumu ʻia e ka hemahema folate hiki ke alakaʻi i ka genome instability a me DNA mutations. Hoʻopili pū ʻo Folate i ka pōʻai homocysteine ​​/ methionine a me S-adenosylmethionine, kahi mea hāʻawi methyl no nā hopena methylation. No laila, hiki i ka hemahema folate ke hoʻopili i ka DNA a me ka methylation protein a hoʻololi i ka hōʻike o nā gen i pili i ka hoʻomaikaʻi ʻana o DNA, ka mahele ʻana o ka cell a me ka make. ʻO ka hypomethylation DNA ākea, kahi hōʻailona maʻamau o ka maʻi ʻaʻai, ke kumu o ka paʻa ʻole o ka genome a me nā haki chromosomal.

ʻO ka ʻai ʻana ma ka liʻiliʻi he ʻelima mau lawelawe o nā hua a me nā lau i ka lā e pili ana me ka emi ʻana o ka maʻi ʻaʻai i kēia lā. ʻO nā hua a me nā huaʻai nā kumuwaiwai maikaʻi loa o ka folate, a he mea nui paha ia i kā lākou hopena anti-carcinogenic.

ʻO ka maʻi a Alzheimer a me ka dementia

ʻO ka maʻi ʻo Alzheimer ka ʻano maʻamau. Loaʻa i kahi noiʻi kahi hui ma waena o ka hoʻonui ʻana i ka lawe ʻana i nā huaʻai a me nā mea kanu i waiwai i ka folate a me ka hoʻemi hoʻemi o ka dementia i nā wahine.

Ma muli o kāna kuleana i ka synthesity o nā nucleic acid a me ka hāʻawi ʻana i ka methyl lawa no nā hopena methylation, hoʻopili ka folate i ka ulu maʻamau a me ka hana o ka lolo, ʻaʻole wale i ka wā o ka hāpai ʻana a ma hope o ka hānau ʻana, akā ma hope hoʻi i ke ola. I hoʻokahi mahele ʻāpana o nā wahine ʻelemakule, ʻoi aku ka nui o nā kiʻekiʻe o nā homosistine kiʻekiʻe a me nā pae folate koko haʻahaʻa i hoʻohālikelike ʻia i ka poʻe olakino. Eia hou, ua hoʻoholo ka ʻepekema ʻo nā pae folate koko lōʻihi lōʻihi, ma mua o ka hoʻohana hou ʻana, he kuleana no ka pale ʻana i ka dementia. ʻO kahi makahiki ʻelua, ʻike ʻole ʻia, placebo-kāohi ʻia i hoʻopaʻa ʻia ma 168 poʻe maʻi me ka hōʻino noʻonoʻo ʻole i loaʻa i nā pono o ka loaʻa ʻana o 800 mcg folate i kēlā me kēia lā, 500 mcg wikamina B12, a me 20 mg vitamin B6. Atrophy o kekahi mau wahi o ka lolo i loli ʻia e ka maʻi o Alzheimer i ʻike ʻia i loko o kēlā me kēia o nā hui ʻelua, a ua hoʻopili ʻia kēia atrophy me ka hoʻohaʻahaʻa ʻike; akā naʻe, ua mālama ʻia ka hui me nā huaora B i emi iki ka hina o ka mea i hoʻohālikelike ʻia i ka placebo group (0,5% versus 3,7%). ʻO ka hopena maikaʻi loa i loaʻa i nā mea maʻi me ka nui o nā kumu homocysteine ​​haʻahaʻa, e hōʻike ana i ke koʻikoʻi o ka hoʻohaʻahaʻa ʻana i ka homocysteine ​​i ka pale ʻana i ka hoʻohaʻahaʻa noʻonoʻo a me ka dementia. Me ka hopena o kāna hopena hoʻohiki, pono e ʻimi hou ʻia ka waihona B-vitamin i loko o nā noiʻi nui aʻe e loiloi i nā hopena lōʻihi, e like me ka maʻi o Alzheimer.

kaumaha

Ua pili nā pae folate haʻahaʻa i ke kaumaha a me ka pane maikaʻi ʻole i nā antidepressants. Ua ʻike ʻia kahi noiʻi hou o 2 mau makahiki nona ka makahiki 988 a hiki i ka 1 ma United States i ka hoʻohaʻahaʻa nui ʻia o ka serum a me ka ʻulaʻula i nā kānaka kaumaha loa ma mua o ka poʻe i kaumaha ʻole. Ua ʻike ʻia nā noiʻi ma 39 mau kāne a me nā wahine i ʻike ʻia me ka maʻi depressive he 52 wale nō i ka 1 mau mea maʻi me nā pae folate haʻahaʻa i pane i ka mālama antidepressant, hoʻohālikelike ʻia me 14 o nā maʻi he 17 me nā pae folate maʻamau.

ʻOiai ʻaʻole i ʻōlelo ʻia kahi supplemental folic acid ma ke ʻano he pani no ka lāʻau antidepressant kuʻuna, pono paha ia ma ke ʻano he mea hoʻohui. I kahi noi ʻana ma UK, ua koho ʻia he 127 mau mea ʻehaʻeha e lawe i 500 mcg folate a i ʻole kahi placebo i hoʻohui ʻia me 20 mg fluoxetine (kahi antidepressant) i kēlā me kēia lā no 10 mau pule. ʻOiai ʻaʻole koʻikoʻi ka hopena o nā kāne, ʻoi aku ka maikaʻi o nā wahine i loaʻa ka fluoxetine me folic acid ma mua o ka poʻe i loaʻa ka fluoxetine plus placebo. Ua hoʻoholo nā mea kākau noiʻi ʻo folate "he kuleana kūpono paha ma ke ʻano he mea kōkua i ka lapaʻau maʻamau no ke kaumaha."

Nā kūmole hana o ka wikamina B9

ʻO ka ʻano maʻamau o ka waikawa folic nā papa. Hiki ke ʻokoʻa ke ana o ka wikamina, pili i ke kumu o ka lāʻau. I nā wikamina no nā wahine hāpai, ʻo ka maʻa maʻamau ka 400 mcg, ʻoiai ua manaʻo ʻia kēia nui no ka ulu olakino o ka fetus. Hoʻokomo pinepine ʻia ka waikawa folic i loko o nā complexes vitamina, me nā huaʻai B ʻē aʻe. Hiki ke ʻano o ia ʻano paʻakikī i ke ʻano o nā papa, a me ke ʻano o ka nau ʻana i nā pā, nā papa i hiki ke hoʻoheheʻe ʻia, a me nā mea i hoʻokomo ʻia.

E hoʻohaʻahaʻa i nā pae homocysteine ​​koko, maʻa mau 200 mcg i 15 mg folate i hāʻawi ʻia i kēlā me kēia lā. Ke mālama ʻana i ke kaumaha, lawe i 200 a 500 mcg o ka wikamina i kēlā me kēia lā, me ka hoʻohui i ka lapaʻau nui. Pono e kau ʻia kēlā me kēia kaha e ke kauka e hele nei.

Folic acid i ka lāʻau kuʻuna

ʻO ka poʻe hoʻōla kuʻuna, e like me nā kauka i ka lāʻau lapaʻau kuʻuna, ʻike i ka mea nui o ka waikawa folic no nā wahine, keu hoʻi nā wahine hāpai, a me kāna kuleana i ka pale ʻana i nā maʻi puʻuwai a me ka anemia.

ʻIke ʻia ʻo Folic acid, ma kahi laʻana, i loko. Paipai ʻia nā hua no nā maʻi o nā puʻupaʻa, nā ake, nā kīʻaha koko a me ka puʻuwai. Ma waho aʻe o ka folate, waiwai pū kekahi i nā strawberry i nā tannins, potassium, hao, phosphorus, cobalt. No nā kumu lāʻau, hoʻohana ʻia nā hua, nā lau a me nā aʻa.

ʻO Folate, a me nā aila kūpono, ka wikamina C, carotene, flavonoids a me tocopherol, i loaʻa i nā ʻanoʻano. ʻO ka mea kanu ponoʻī kahi hua a me ka hopena diuretic, hoʻomaha i nā spasms a hoʻomaʻemaʻe i ke kino. ʻO ka infusion a me ka decoction o nā hua e kōkua me ka mumū o ka membrane mucous o ka urinary tract. Hoʻohui ʻia, kuhikuhi ʻia ka pāhola parsley no ke kahe ʻana o ka uterine.

Manaʻo ʻia kahi kumu waiwai o ka folic acid i ka lāhui. Loaʻa iā lākou he 65 a 85 pakeneka wai, 10 a 33 pakeneka kō, a me kahi nui o nā mea pono - nā waikawa like ʻole, nā tannins, potassium, magnesium, calcium, manganese, cobalt, iron, vitamins B1, B2, B6, B9, A, C, K, P, PP, nā enzymes.

ʻImi ʻepekema hou loa e pili ana i ka wikamina B9

• ʻO ka ʻai ʻana i nā kaha kiʻekiʻe o ka folic acid ʻaʻole ia e hoʻopili i ka makaʻu o ka hoʻomohala ʻana i ka preeclampsia. He kūlana olakino koʻikoʻi ia i hōʻike ʻia e ka hoʻomohala ʻana i ke kiʻekiʻe o ke koko kiʻekiʻe i ka wā hāpai a me nā pilikia ʻē aʻe. Weliweli kēia ʻano no ka makuahine a me ke keiki. Ua ʻōlelo ʻia ma mua e hiki i nā mahele kiʻekiʻe o folate ke hoʻemi i ka makaʻu o ka hoʻomohala folate i nā wahine i predisposed i ka maʻi. Hoʻopili kēia i nā mea i loaʻa i ke koko kiʻekiʻe ka lōʻihi; nā wahine e ʻeha nei a i ʻole; hapai me nā māhoe; a me nā mea i loaʻa i ka preeclampsia i nā hāpai mua. ʻO ke aʻo ʻana i loko o 2 tausani mau wahine hāpai i waena o 8 a 16 mau pule. Ua ʻike ʻia ka lawe ʻana i 4 mg o ka folic acid i kēlā me kēia lā ʻaʻole i pili i ka makaʻu o ka hoʻomohala ʻana i ka maʻi ke hoʻohālikelike ʻia me ka poʻe i lawe i kahi placebo me ka 1 mg maʻamau o folate (14,8% o nā hihia a me 13,5% o nā hihia. , pakahi). Eia nō naʻe, paipai nā kauka i ka lawe ʻana i kahi lāʻau haʻahaʻa o ka folate ma mua a i ka wā o ka hāpai ʻana e pale ai i ka ulu ʻana o nā maʻi hānau.
• Ua hoʻoholo ka poʻe ʻepekema ʻIlani he hapa nui o ka poʻe ma kahi o 50 i hemahema i ka wikamina B12 (1 i ka 8 poʻe) a me ka folate (1 i ka 7 poʻe). ʻOkoʻa ke kēkelē o ka hemahema me ka nohona, ke olakino a me ke kūlana nutritional. Pono nā huaora ʻelua i ke olakino o ka ʻōnaehana, ka lolo, ka hana ʻana o ke koko ʻulaʻula, a me ka mahele DNA. Ua ʻike ʻia nō hoʻi ka piʻi ʻana o ka pākēneka o ka hemahema folate me ka makahiki - mai ka 14% ma waena o ka poʻe he 50-60 mau makahiki, a 23% i waena o nā mea he 80 a ʻoi ka makahiki. ʻIke pinepine ʻia ia i nā mea puhipaka, nā poʻe momona a me nā poʻe i noho kaʻawale. ʻOi aku ka maʻamau o ka hemahema ʻo Vitamin B12 i ka poʻe puhihihi (14%), noho wale (14,3%), a me nā poʻe mai nā haʻahaʻa haʻahaʻa haʻahaʻa haʻahaʻa.
• Koi ka poʻe ʻepekema Pelekane i ka hoʻonui ʻana i ka palaoa a me nā meaʻai ʻē aʻe me ka waikawa folic. Wahi a nā mea kākau o ka noiʻi, i kēlā me kēia lā ma Pelekane, ma ka awelika, ʻelua mau wahine i koi ʻia e hoʻopau i kā lākou hāpai ʻana ma muli o ka maʻi neural tube, a hānau ʻia ʻelua pēpē me kēia maʻi i kēlā me kēia pule. ʻO Pelekane kekahi o nā ʻāina kahi o ka nohona folate ka mea maʻamau, ʻokoʻa ka United States a me nā ʻāina ʻē aʻe. "Inā ua ʻae ʻo Pelekane i ka hana paʻa folate ma 1998, e like me ʻAmelika, ma kahi o 2007 hiki ke hōʻalo ʻia nā hemahema hānau e 3000," wahi a Professor Joan Morris.

Hoʻohana i ka cosmetology

He mea nui loa ka acid Folic i loko. Aia i loko o kahi lehulehu o nā antioxidants e hoʻēmi i ka hana o nā kaʻina hana oxidative a hoʻonele i nā radical manuahi i loaʻa i ke kaiapuni. ʻO nā waiwai hānai hānai Folic acid e kōkua pū kekahi i ka mālama ʻana i ka ʻili me ka hoʻoikaika ʻana i ka pale o ka ʻili. Māhele kēia i ka makū a hoʻemi i ka maloʻo.

I loko o nā mea hoʻonaninani, hoʻokomo pinepine ʻia nā huahana folate i loko o nā lotion moisturizing a me nā creams, i ka wā i hoʻohana ʻia ma luna, hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka maikaʻi a me ke ʻano o ka ʻili.

Hoʻohana holoholona

ʻIke ʻia ka hemahema o ka acid acid i nā ʻano holoholona he nui, i hōʻike ʻia ma ke ʻano o ka anemia, kahi hoʻemi o ka nui o nā leukocytes. ʻO ka hapa nui o nā pūnaewele me kahi kiʻekiʻe o ka ulu ʻana o ka pūnaewele a i ʻole ka hoʻōla hou ʻana o ke kino, e like me ka membrane epithelial o ka gastrointestinal tract, epidermis a me ka iwi iwi. I nā ʻīlio a me nā pōpoki, pili pinepine ka anemia me ka hemahema folate i hoʻokumu ʻia e nā syndromes malabsorption ʻōpū, malnutrice, antagonists folate, a hoʻonui ʻia paha nā koi folate ma muli o ke kahe o ke koko a hemolysis paha. No kekahi mau holoholona e like me nā puaʻa guinea, nā mōʻī a me nā puaʻa, pono ka lawa ʻana o ka folate i ka papaʻai. I nā holoholona ʻē aʻe, e like me nā ʻīlio, nā pōpoki, a me nā iole, ʻo ka waikawa folic i hana ʻia e ka microflora ʻōpū e lawa pono ia e kū pono ai nā pono. No laila, hiki i nā hōʻailona o ka hemahema ke ulu inā hoʻokomo ʻia kahi antiseptic ʻōpū i loko o ka papaʻai e kāohi ai i ka ulu ʻana o ke koʻohune. Hana ʻia ka hemahema folate i nā ʻīlio a me nā pōpoki, me nā antibiotic wale nō. ʻO ka hapa nui o nā koi o kēlā me kēia lā no ka folate e hoʻokō ʻia e ka synthes bacterial i loko o ka ʻōpū.

Nā Contraindications a me nā akahele

Ma kahi o 50-95% o ka waikawa folic i luku ʻia i ka wā kuke ʻana a me ka mālama ʻana. ʻO nā hopena o ka lā a me ka lewa e hōʻino pū kekahi i ka folate. E mālama i nā meaʻai i loko o ka folate i loko o kahi pahu hakahaka pouli i ke ana wela o ka lumi.

Nā hōʻailona o ka hemahema folate

Kākaʻikahi nā hemahema i loko o ka waikawa folic a pili pinepine ʻia me nā hemahema o ka momona ma muli o ka malnutrisi a i ʻole nā ​​maʻi absorption. ʻO nā ʻōuli maʻamau ka nāwaliwali, pilikia i ka noʻonoʻo ʻana, ka huhū, nā palpitations o ka naʻau, a me ka hanu liʻiliʻi. Hoʻohui ʻia, loaʻa paha i ka ʻeha a me nā puʻupuʻu ma ke alelo; nā pilikia me ka ʻili, ka lauoho, nā kui; nā pilikia i ka gastrointestinal tract; nā kiʻekiʻe kiʻekiʻe o ka homocysteine ​​i ke koko.

Nā ʻōuli o ka wikamina B9 keu

Ma ka laulā, ʻaʻohe hopena o ka lawe ʻana i ka folate nui. I nā hihia kakaikahi, hiki i nā lāʻau kiʻekiʻe loa o folate ke hōʻeha i nā puʻupaʻa a lilo i ka make o ka makemake. Lawe i ka nui o ka wikamina B9 hiki ke hūnā i ka hemahema o ka wikamina B12. ʻO ka mahele lāʻau nui i hoʻokumu ʻia i nā lā āpau o ka folate no kahi makua ʻo 1 mg.

Hoʻopili kekahi mau lāʻau i ka lawe ʻana o ka wikamina B9 i loko o ke kino, i waena o lākou:

• pale pale waha;
• methotrexate (hoʻohana ʻia i ka mālama ʻana i ka maʻi ʻaʻai a me nā maʻi autoimmune);
• nā lāʻau antiepileptic (phenytoin, carbamazepine, valproate);
• sulfasalazine (hoʻohana e mālama i ka ulcerative colitis).

E heluhelu e pili ana i nā wikamina ʻē aʻe: