ʻO ka fecal elastase kahi enzyme i hana ʻia e ka pancreas e hana i kahi hana i ka ʻai ʻana. Hiki i kāna dosage ke loiloi i ka hana kūpono o ka hana o ka pancreas e pili ana i ka digestion.

ʻO ka pancreas kahi ʻāpana o ke kino o ke kanaka he ʻelua mau hana:

• He hana endocrine no 10% o nā pūnaewele: huna ka pancreas i ka insulin a me ka glucagon, ʻelua mau hormones e mālama i ka pae o ke kō i loko o ke koko. Hoʻemi ka insulin i ke kō koko a hoʻonui ka glucagon. ʻO kēia mau hormones ʻelua e kōkua i ka mālama ʻana i nā pae kōpaʻa koko. Inā loaʻa kahi pilikia me ka huna ʻana o ka insulin, kamaʻilio mākou e pili ana i ka maʻi diabetes;
• he hana exocrine no 90% o nā pūnaewele: by acinar cell, huna ka pancreas i nā enzyme pancreatic, nā protein me kahi kuleana kikoʻī. ʻO kēia mau enzymes he ʻāpana o ka wai pancreatic a he mea nui ia no ka hoʻoemi pono ʻana i ka meaʻai. Ma o ke kuʻi ʻana o nā ala Wirsung a me Santorini, haʻalele nā ​​wai pancreatic i ka pancreas e hele mai a hui pū me ka bile i loko o ka ʻōpū. I loko o ka digestive tract, komo kēia mau enzymes i ka ʻeli ʻana o nā momona, nā protein a me nā ʻakika ma o ka wāwahi ʻana iā lākou i loko o nā mea he nui, ʻoi aku ka maʻalahi o ke kino.

ʻO Fecal elastase kekahi o nā enzyme i hana ʻia e ka pancreas. Hana ʻia ia ma ke ʻano paʻa a mau, e hana ai i kahi hōʻailona pancreatic maikaʻi. ʻO ke kumu o ka fecal elastase assay ka loiloi i ka hana kūpono o ka hana exocrine o ka pancreas. ʻO ka waiwai kuhikuhi he 200 micrograms no ka gram of stool i nā pākeke a me nā keiki (mai hoʻokahi mahina mai). Paʻa kēia waiwai a ʻano liʻiliʻi ka liʻiliʻi mai kekahi lā a i kekahi i ke kanaka hoʻokahi koe wale nō ka hihia o ka maʻi maʻi nui e hoʻoheheʻe i ke kiʻekiʻe o ka fecal elastase. I kēia hihia, pono e hana hou ʻia ka loiloi. He ho'āʻo maʻalahi loa ia e hana ai, hiki ke hoʻololi ʻia no nā hoʻokolohua paʻakikī ʻē aʻe e like me ke aʻo ʻana i ka steatorrhea.

Hana ʻia kēia hoʻokolohua e loiloi i ka hana o ka hana exocrine o ka pancreas. Hiki ke hoʻokō ʻia i ka wā o ka kānalua o ka exocrine pancreatic insufficiency. Hiki ke noi ʻia e ke kauka e hoʻoholo i nā kumu o ka pilikia maʻi maʻi mau.

Hoʻoholo ʻia ka hoʻoholo ʻana o ka faecal elastase ma kahi laʻana stool. Hiki i ka mea maʻi ke hōʻiliʻili i ka laʻana ma kona home me nā mea i hāʻawi ʻia e ke keʻena loiloi lāʻau lapaʻau. A laila e hoʻolei koke ʻo ia i ka hāpana i loko o ka hale hana no ka nānā ʻana. Pono e mālama ʻia ka laʻana ma 4 ° C (i loko o ka friji). Pono e hana ʻia ka nānā ʻana i loko o 48 mau hola ma hope o ka hōʻiliʻili ʻana i ka stool. He ho'āʻo ELISA ʻano sandwich kēia, kikoʻī no ka elastase kanaka (elastase E1). Aia kēia ho'āʻo i ka hoʻokaʻawale ʻana i ka protein ma waena o ʻelua antibodies, e ʻike ana kēlā me kēia i kahi ʻāpana o ka protein, no laila e hiki ai ke ʻike a helu.

Inā hoʻonui ʻia ka mea maʻi me ka enzyme replacement therapy, ʻaʻohe hopena i ke ʻano o ka fecal elastase. ʻO ka mea ʻē aʻe, pono e pale ʻia kekahi mau mea i ka pule ma mua a ma ka lā o ka laʻana:

• nā hoʻokolohua radiological digestive;
• nā hoʻomākaukau no ka colonoscopy;
• laxatives;
• ʻaʻahu ʻōpū a i ʻole nā ​​lāʻau anti-diarrhea. ʻOiaʻiʻo, hiki i kēia mau mea ke hoʻololi i ka flora intestinal a hoʻopunipuni paha i nā hopena o ka loiloi.

Pēlā nō, pono e pale aku, inā hiki, i kēia hoʻokolokolo ʻana i ka wā maʻi maʻi nui. Inā hikiʻole kēia, pono e kuhikuhiʻia i hiki i ke kauka ke noʻonoʻo i ka wā e nānā ai i nā hopena.

ʻO kahi haʻahaʻa haʻahaʻa loa o ka fecal elastase (koe wale ka hihia o ka maʻi maʻi) e hōʻike ana i ka lawa ʻole o ka hana exocrine o ka pancreas. ʻO ka neʻe ʻana ma waena o 150 a me 200 µg / g kahi hōʻailona o ka lawa ʻole o ka exocrine pancreatic. Ke kamaʻilio nei mākou e pili ana i ka lawa ʻole o ka exocrine pancreatic i ka wā o ka pae o ka fecal elastase ma lalo o 15 µg / g.

Mai laila, pono ke kauka e hana hou i nā hoʻokolohua, nā hoʻokolohua a me nā kiʻi e hoʻoholo ai i ke kumu o kēia hemahema. Nui nā mea hiki:

• pancreatitis mau loa;
• huikau pancreatitis;
• cystic fibrosis;
• maʻi diabet;
• maʻi celiac ;
• ʻO ka maʻi o Crohn;
• ʻO ka maʻi maʻi Zollinger-Ellison;
• ʻoki ʻana i ka ʻāpana digestive luna;
• etc.