ʻO ka hypogammaglobulinemia ka emi ʻana o ke kiʻekiʻe o ka gamma-globulins a i ʻole immunoglobulins, nā mea i loaʻa ke kuleana nui i ka ʻōnaehana pale. Hiki i kēia anomaly biological ma muli o ka lawe ʻana i kekahi mau lāʻau lapaʻau a i ʻole nā ​​pathologies like ʻole, ʻo kekahi o ia mau mea e koi ai i kahi maʻi wikiwiki. 

Hōʻike ʻia ka hypogammaglobulinemia e kahi pae gamma-globulin ma lalo o 6 g / l ma ka plasma protein electrophoresis (EPP). 

ʻO ka gamma globulins, i kapa ʻia hoʻi he immunoglobulins, he mau mea i hana ʻia e nā ʻili koko. He kuleana koʻikoʻi ko lākou i nā pale o ke kino. ʻO ka Hypogammaglobumonemia e alakaʻi i kahi hōʻemi koʻikoʻi a i ʻole ka nui o nā pale pale. He kakaikahi.

ʻO ka hoʻokolokolo e hiki ai ke hoʻoholo i ka gamma-globulins, ma waena o nā mea ʻē aʻe, ʻo ia ka electrophoresis o nā protein serum a i ʻole nā ​​protein plasma. 

Kuhi ʻia kēia hōʻike ʻana i ka hihia o ka kānalua o kahi hemahema humoral immune i mua o nā maʻi pinepine, ʻoi aku ka nui o ka ENT a me ka bronchopulmonary sphere a i ʻole ka deterioration o ke kūlana maʻamau, i ka hihia o ka kānalua o ka myeloma lehulehu ( nā hōʻailona: ʻeha iwi, anemia, nā maʻi pinepine…). 

Hiki ke hoʻohana ʻia kēia hoʻāʻo ma hope o nā hopena ʻino e hōʻike ana i ka piʻi ʻana a i ʻole ka emi ʻana o ka protein serum, ka protein kiʻekiʻe o ka mimi, ka calcium koko kiʻekiʻe, kahi ʻano like ʻole o ka helu o nā keʻena koko ʻulaʻula a i ʻole nā ​​​​kelepona koko keʻokeʻo.

ʻO ka electrophoresis o nā protein serum ka hoʻokolokolo e hiki ai ke ana i ka gamma globulins. 

ʻO kēia hoʻāʻo biology maʻamau (ka laʻana koko, maʻamau mai ka kuʻekuʻe) hiki ke hoʻokokoke nui o nā ʻāpana protein like ʻole o ka serum (albumin, alpha1 a me alpha2 globulins, beta1 a me beta2 globulins, gamma globulin). 

ʻO ka electrophoresis o nā protein serum he hōʻike maʻalahi e hiki ai ke ʻike a komo i ka nānā ʻana i nā pathologies he nui: inflammatory syndromes, kekahi mau maʻi maʻi maʻi, physiological a i ʻole nā ​​​​meaʻai.

Ke kuhikuhi nei ia i nā hoʻokolohua hou e pono ai (immunofixation a me / a i ʻole nā ​​hōʻike kikoʻī o nā protein, loiloi haematological, renal a i ʻole digestive exploration).

ʻO ka loaʻa ʻana o ka hypogammaglobulonemia ma muli paha o ka lawe ʻana i nā lāʻau lapaʻau (oral corticosteroid therapy, immunosuppressants, anti-epileptics, tumor chemotherapy, etc.) a i ʻole nā ​​maʻi like ʻole. 

ʻO nā hoʻokolohua hou aʻe e ʻae i kahi hōʻailona ke hoʻopau ʻia ke kumu lāʻau. 

No ka ʻike ʻana i nā maʻi maʻi he mau pilikia diagnostic (light chain myeloma, lymphoma, chronic myeloid leukemia), ʻekolu mau hoʻokolohua e hana ʻia: ʻo ka ʻimi ʻana i kahi maʻi tumora (lymphadenopathy, hepato-splenomegaly), ka ʻike ʻana i ka proteinuria a me ka helu koko.

I ka wā i hoʻokuʻu ʻia ai kēia mau pilikia ulia pōpilikia, ʻōlelo ʻia nā kumu ʻē aʻe o ka hypogammaglobulonemia: nephrotic syndrome, exudative enteropathies. ʻO nā kumu o ka exudative enteropathies hiki ke lilo i ka maʻi inflammatory bowel maʻi, ka maʻi celiac a me nā maʻi maʻi digestive paʻa a i ʻole kekahi lymphoid hemopathies e like me lymphoma a i ʻole amyloidosis mua (LA, light chain amyloidosis of immunoglobulins).

ʻOi aku ka kakaikahi, hiki i ka hypogammaglobulinemia ke kumu ma muli o ka nele o ka immune humoral.

ʻO ka maʻi ʻai nui a i ʻole Cushing's Syndrome ke kumu o ka hypogammaglobulinemia.

ʻO nā hoʻokolohua hou aʻe e hiki ke hana i ka maʻi maʻi (thoraco-abdominal-pelvic scanner, helu koko, hana inflammatory, albuminemia, proteinuria 24-hola, hoʻoholo kaumaha o nā immunoglobulins a me ka immunofixation koko)

Hoʻoponopono i ka hopena. 

Hiki ke hoʻonohonoho i kahi lapaʻau pale i ka poʻe e loaʻa ana i ka hypogammaglobulinemia: anti-pneumococcal vaccination a me nā lāʻau lapaʻau ʻē aʻe, antibiotic prophylaxis, hoʻololi i nā immunoglobulins polyvalent.