ʻO ke kuleana o ka ADH hormone e nānā i ka nalo ʻana o ka wai e nā puʻupaʻa, no laila he mea nui ia no kāna hana kūpono. Minamina, ʻaʻohe kūpono o ka hūnā ʻana o kēia hōmona mai kēlā manawa a kēia manawa. He aha nā kumu? Hiki paha i ke kiʻekiʻe a i ʻole ka haʻahaʻa o kēia hormone ke hana ʻia?

ʻO ka hormone antidiuretic i kapa ʻia hoʻi ʻo vasopressin, i kekahi manawa e kuhikuhi ʻia e ka pōkole AVP no Arginine-vasopressin, kahi homone synthesized e nā neurons o ka hypothalamus. Ma kaʻae ʻana i ka reabsorption o ka wai e ke kino, hoʻopili ka hormone ADH i kāna hana i nā puʻupaʻa.

Ke hūnā ʻia e ka hypothalamus, e mālama ʻia ia i ka pituitary gland ma mua o ka hoʻokuʻu ʻia inā loaʻa ka make wai. Aia ka hypothalamus a me ka pituitary ma ke kumu o ka lolo.

ʻO ke kuleana o ADH e nānā i ka nalo ʻana o ka wai mai nā puʻupaʻa (diuresis) e hōʻoia i ka pae o ka sodium i ka pae i kahi pae maʻamau. Ke piʻi ka pae sodium, hūnā ʻia ʻo ADH e kaupalena i ka nalo ʻana o ka wai mai nā puʻupaʻa, a pouli loa ka mimi.

Hoʻonohonoho ʻia kāna ana e hoʻoholo a hoʻokaʻawale i ka nephrogenic diabetes insipidus mai ke kikowaena diabetes insipidus a i ʻole ke kū ʻana o kahi syndrome secretion kūpono.

Hiki ke hoʻopili ʻia nā pae hormone antidiuretic haʻahaʻa i:

• Insipidus diabetes : ʻaʻole mālama ka puʻupaʻa i ka wai a me nā kānaka a laila hana i ka mimi nui a dilute (polyuria) a pono lākou e uku ʻia e ka inu ʻana i ka nui o ka wai (polydipsia). Aia he ʻelua ʻano diabetes insipidus, insipidus diabetes waena (CDI), ka mea maʻamau a hoʻokumu ʻia e ka hemahema ADH, a me ka nephrogenic diabetes insipidus, aia ka hōmona akā ʻaʻole holo.

Hiki ke hoʻopili ʻia nā pae hormone antidiuretic kiʻekiʻe me:

• ʻAE : Hoʻākāka ʻia ka Syndrome o ka huna pono ʻole ʻia o ka hormone antidiuretic e hyponatremia i hoʻokomo ʻia e ka hoʻonui ʻia o ka wai i ke koko me ka pae sodium i hoʻemi ʻia. ʻO ka pinepine o ka hypothalamic (kahe, ka puhū), ka ʻōpū tumor (lung cancer). ʻO nā ʻōuli o ka hyponatremia ka nausea, ka luaʻi, huikau;
• Nā leona o ka ʻōnaehana ʻōiwi: nā maʻi, nā ʻeha, nā hemorrhages, nā tumors;
• Meningoencephalitis a i ʻole polyradiculoneuritis;
• ʻO kahi trauma craniocerebral;
• Epilepsy a i ʻole ka hopu ʻana i nā psychotic maha.

I loko o kahi hāpana koko, ana ʻia ka hōkū anti-diuretic. A laila, kau ʻia ka hāpana i kahi centrifuge ma 4 ° a i ka hopena ua paʻa i ka -20 °.

ʻAʻole kūpono ka noho ʻana i kahi ʻōpū nele no kēia hoʻokolokolo.

Me ka ʻole o ka palena wai, ʻo nā kumukūʻai maʻamau o kēia hormone ma lalo o 4,8 pmol / l. Me ka palena o ka wai, nā waiwai maʻamau.

Kaukaʻi ʻia i nā pathology, aia kekahi mau ʻano lapaʻau ʻokoʻa:

Lapaʻau no ka maʻi diabetes insipidus

Hoʻohana ʻia ka mālama ʻana e like me ke kumu i ʻike ʻia, a pono e mālama ʻia inā aia hoʻokahi. I kēlā me kēia hihia, ʻaʻole pono ʻoe e waiho i ke kanaka e maloʻo a i ʻole overhydrated a hoʻāʻo e kaulike iā ia me kahi papa paʻakai haʻahaʻa.

• I ke kumu o ka insipidus diabetes waenakonu, hoʻokumu ʻia ka lāʻau ma ka loaʻa ʻana o kahi hormone e like me ka antidiuretic hormone, desmopressin, nona ka mana antidiuretic e mana ai. Hoʻonohonoho pinepine endonasal i hoʻokahi a ʻelua mau manawa i ka lā. E mālama pono ʻaʻole e ʻoi aku i ka lāʻau i kauoha ʻia e kāu kauka no ka mea ʻoi aku ka nui i hiki ai i ka paʻa ʻana o ka wai a i kekahi manawa i nā haunaele.
• I ke kumu o ka nephrogenic diabetes insipidus, ʻaʻole holo pono kēia hana hormonal. No laila pono e mālama ʻia ka maʻi maʻi maʻi.

Hoʻomaʻamaʻa i ka Syndrome o ke kūpono kūpono Antidiuretic Hormone:

Ka palena o ka lawe ʻana i ka wai a me ka mālama ʻana i ke kumu inā hiki. Pono ka poʻe me SIADH i ka lāʻau no hyponatremia no ka manawa lōʻihi.

Hāʻawi ʻia i nā wai i loko o ke kino, ʻo nā wai hoʻi me nā kiʻekiʻe kiʻekiʻe loa o ka sodium (saline hypertonic). Pono e hāʻawi ʻia i kēia mau mālama me ke akahele e pale ai i ka piʻi wikiwiki ʻana o ka sodium sodium (ka paʻakai sodium i ke koko).

Inā hoʻomau ka hāʻule o ke serum o ke koko a piʻi ʻole paha me ka palena o ka lawe ʻana o ka wai, hiki i nā kauka ke kuhikuhi i nā lāʻau e hōʻemi i ka hopena o vasopressin ma nā puʻupaʻa, a i ʻole nā ​​lāʻau e ālai i nā mea loaʻa vasopressin a pale i nā puʻupaʻa. pane iā vasopressin.