Contents
- ʻO ka hormone Anti-Müllerian: ka mea e ʻike ai nā kaikamahine nulliparous āpau e pili ana
- No ke aha i kapa ʻia ai ka AMG he hōʻike litmus o ke olakino wahine
- I ka manawa hea e loiloi ai i ka pae o AMH
- Pehea e hoʻomākaukau ai no kahi hōʻike AMG
- He aha ka hōʻike ʻana i ka hōʻemi a hoʻonui ʻana o nā pae AMH?
ʻO ka hormone Anti-Müllerian: ka mea e ʻike ai nā kaikamahine nulliparous āpau e pili ana
Hōʻike maikaʻi kāna mau mea hōʻike i ke olakino o ka ʻōnaehana hānau. Inā ʻoe e hoʻolālā e hānau ma hope o 35 mau makahiki, pono e hoʻāʻo wale ʻia no kēia hōmona.
He hōʻailona koʻikoʻi ka anti-Müllerian hormone. ʻO kēia kahi mea e hiki ai i ke kauka ke loiloi i ka hiki i ka wahine hānau a me nā hoʻololi kūpono i ka hana o nā ovaries.
alakaʻi i ka gynecologist-reproductologist o ka pūnaewele o nā kikowaena o ka hana hou a me nā genetics "Nova Clinic"
ʻO ka hormone anti-Müllerian - AMG - aia pū kekahi i ke kino kāne. I ke kaʻina o ka ulu mua ʻana o intrauterine, ʻo ia ka mea e hoʻoholo i ka ulu ʻana o ka embryo kāne. I ka wā makua, i ke kino kāne, hoʻomau ʻia e hūnā ʻia e kekahi mau hunaola i loko o nā testicle ka anti-Müllerian hormone, a ʻo ka loiloi o ka pae o kēia hormone e kōkua ai i ka hōʻoia ʻana i nā ʻano ʻano nui o ka male infertility.
I ke kino wahine, hūnā ʻia e ka hunaola Mūllerian e nā hunaola i loko o nā ovarian follicles. Hoʻololi ka helu o nā follicle i ke ola a kau palena ʻia. E hoʻonui ʻia ia ma ke kahua o ka hoʻomohala intrauterine.
Minamina, inā hoʻemi ʻia ka helu o nā follicle, ʻaʻole hiki iā ʻoe ke hoʻoikaika i ke kino e hana i nā mea hou aʻe. Ke pau nā lako, hele mai ka menopause. He hana kūlohelohe kēia o ka hoʻopau ʻana o ka hana hānau, ke hiki ʻole i ka hana maʻamau o ka meaola a me ke kaʻina o ke kaʻina menstrual.
I ka hoʻomaka o kēlā me kēia pōʻai menstrual, komo kekahi helu o nā follicle i ka ulu ulu i ka ovary. ʻO ka ʻōpio ka wahine, ʻoi aku ka nui o lākou i hoʻokahi pōʻaiapuni: ma 20-25 mau makahiki i 20-30, ma 40 - 2-5 wale nō. ʻO kēia mau follicle, i hoʻomaka mua e ulu, ʻike maopopo ʻia ma ka ultrasound. ʻIke lākou e like me nā ʻōmole liʻiliʻi 3-6 millimeter i ka nui.
Koho ʻia kēia mau follicle mai kahi mālama ovarian. ʻO kahi mālama kahi mālama o nā follicle āpau. A ʻo ke kaʻina koho ua kapa ʻia ka hoʻouluulu ʻana. ʻOi aku ka maʻalahi o ka noʻonoʻo ʻana i kēia ma ke ʻano he waihona kālā i kahi panakō hilinaʻi, kahi e hāʻawi ʻia ai i kekahi kālā i kēlā me kēia mahina. ʻO ka haʻahaʻa o ka nui o nā kālā ma ka waihona, ʻo ka haʻahaʻa o ka nui e lilo i kēia mahina. ʻO ia ke kumu, me ka makahiki, me ka hoʻoliʻiliʻi kūlohelohe o ka waihona ovarian, ua emi ka helu o nā follicle i kahi ulu i hāʻawi ʻia. ʻIke maopopo ʻia kēia ma ka ultrasound.
ʻO ka hopena o kēia mau follicle i koho ʻia i koho mua ʻia. E lilo kekahi o lākou i mea nui, i ke kaʻina hana o ka ovulation, e hoʻokuʻu ʻia kahi hua manu mai ia mea, i mea e hiki ai ke hāpai i ka hāpai keiki. Kū nā mea ʻē aʻe i ka hoʻomohala ʻana, undergo atresia (i ka ʻoiaʻiʻo, hoʻololi i ka hoʻomohala, pani ʻia me nā mea pili).
No ke aha i kapa ʻia ai ka AMG he hōʻike litmus o ke olakino wahine
Hūnā ʻia ka hormone anti-Müllerian e nā hunaola o kēlā mau follicle i mālama ʻia. No ke aha he mea nui? ʻOiai ʻo ia ka pōmaikaʻi nui o kēia hōʻailona ma luna o nā homone ʻē aʻe a me ka helu ʻana i ka helu o nā follicle ma kahi scan ultrasound.
ʻO ka helu o nā follicle, e like me nā ʻōuli o nā hormones ʻē aʻe, hiki ke loli ʻia mai ke kaapuni i ke kaapuni. ʻO kēia paha ma muli o nā peculiarities o ka nui o nā follicle, ka lōʻihi o ke pōʻaiapuni, ma mua o ka hoʻomaʻamaʻa hormonal. Akā e kūpaʻa a kūʻokoʻa ka hormone anti-Müllerian. E hōʻike ia i ka mokuʻāina ʻoiaʻiʻo a me ka helu o nā follicle ʻaʻole no kēia pōʻaiapili kikoʻī, akā no ka mālama ovarian holoʻokoʻa. He hōʻailona kūpono a koʻikoʻi kēia. Hoʻohui ʻia kahi hōʻemi o nā waihona ovarian me ka hōʻemi o nā pae hormone anti-Müllerian, a ʻo ia kahi hōʻemi o kēia mau hōʻailona e hopohopo pinepine nei iā mākou.
I ka manawa hea e loiloi ai i ka pae o AMH
Hoʻopili… Inā ma ka laina wahine (makuahine, kupunawahine, kaikuahine) he mau hana maʻamau o ka menstrual, infertility, menopause mua, a laila he hōʻailona weliweli paha kēia a hōʻike i kahi predisposition hoʻoilina i ka wā make ʻole o ka mālama ovarian.
ʻO nā hana ma nā ʻāpana pelvic, keu hoʻi ma nā ovaries. E kōkua ka pae AMG e hoʻomaopopo i ka mokuʻāina o kahi mālama a i kekahi manawa hoʻololi i nā hana o ka hana. Ma hope o ka hoʻopili ʻana i nā ovaries, e hoʻēmi ka waihona. E kōkua ka pae AMH i ka hoʻoholo i ka wānana a me nā hoʻolālā hānau.
Nā kūleʻa Menstrual… Kūleʻa a i ʻole, ma ka ʻaoʻao ʻē aʻe, maʻa mau, akā hoʻomau ʻia ka pōkole menstrual cycle kahi kumu hoʻi e hāʻawi i ke koko no AMG. ʻO nā hōʻailona mua o ka hoʻoliʻiliʻi ʻike ʻole ʻia i ka mālama e like me ka hoʻēmi o ka lōʻihi o ke kaapuni (ma lalo o 26 mau lā).
Hoopaneeia ka makuahine… Alakaʻi ʻia e kahi ola kaiaulu hana, hoʻopanee nā kaikamahine o kēia wā i ka hāpai hāpai i kahi ʻelemakule makahiki. Hoʻomaka ka ʻōnaehana hānau wahine e ʻike i nā pilikia olaola me ka hāpai ma hope o 35 mau makahiki. I kēia hihia, hiki ke hōʻalo i nā pilikia he nui me ka ʻike mua ʻana i ke kūlana o ka waihona ovarian. I kekahi manawa kūpono ia e vitrify oocytes. He hana olakino kēia e ʻae iā ʻoe e mālama i kāu mau hua manu ma ke kāpae ʻana i ka hāʻule kūlohelohe o ka waihona ovarian i hiki ʻole ke kū ʻia. ʻO nā pilikia me ka hāpai ʻana a hoʻolālā ʻana paha i kahi hāpai ma hope o 35 mau makahiki he mau hōʻailona no ka loiloi i ka pae o AMH.
Pehea e hoʻomākaukau ai no kahi hōʻike AMG
Hiki ke hoʻokō ʻia kahi hoʻokolohua koko no ka anti-Müllerian hormone i kēlā me kēia lā o ke kaʻina menstrual. Ma ke ʻano he rula, hāʻawi manawaleʻa ʻia ʻo AMG me nā hormones wahine ʻē aʻe, a pono e nānā ʻia i ka hoʻomaka o ke pōʻaiapuni (i nā lā 2-5).
Ma mua o ka lawe ʻana i ka AMG, koi ʻia e hōʻole i ka hoʻoikaika kino nui a me ka puhipaka. Ma ke ala, nui nā noiʻi e hōʻoia ana i ka hopena maikaʻi ʻole o ka puhipaka ma ka mokuʻāina o ka waihona ovarian a me ka hōʻemi ʻana o nā pae AMH.
Aia kekahi mea i hiki ke loaʻa i kahi hopena maikaʻi i ka noʻonoʻo o ka anti-Müllerian hormone. Wahi a kekahi mau hōʻike, ʻo ka uku pānaʻi no ka lawa ʻole o ka wikamina D hiki i ka hoʻonui ʻana i nā pae AMH. Kūpono koke ia i ka kuhikuhi ʻana i kahi kiko e hiki ʻole ke hoʻonui i ke kūlana maoli o ka waihona ovarian, ʻo ia hoʻi, ka helu o nā follicle. Minamina, ʻaʻohe ala i kēia manawa e hana ai i kēia, ʻoiai ka palena o ka hāʻawi ʻana o nā hua i nā ovaries.
He aha ka hōʻike ʻana i ka hōʻemi a hoʻonui ʻana o nā pae AMH?
Kūlana maʻamau ʻo ka waihona ovarian i nā makahiki like ʻole i manaʻo ʻia ma ka awelika mai 2 a 4 ng / ml.
Hoʻoemi ovarian mālama ʻo ka pae AMH ʻo 1,2 ng / ml. ʻO ka wānana hānau me ka hoʻemi ʻana o ka AMH ma lalo o 0,5 ng / ml a koʻikoʻi loa, a i kekahi mau hanana e hōʻike paha kēia i ka pono o ka IVF me nā hunaola donor. Maʻaneʻi, he mea nui ke kiʻi ʻana i ke kauka a me ka hoʻolālā ʻana no ka hapai ʻana.
Aia kekahi mau hanana ke hoʻonui ʻia ka AMH. Hiki ke hoʻopili ʻia nā pae kiʻekiʻe ma mua o 6,8 ng / ml me ka polycystic ovary syndrome (PCOS) a i ʻole multifollicular ovary syndrome. ʻO ka hoʻonui nui ʻana o ka AMH ma luna o 13 ng / ml e koi ai i ka hoʻokolokolo hou ʻana a me ke kāpae ʻia ʻana o nā pathology oncological, akā ʻike pinepine ʻia ia ma kekahi ʻano o PCOS.
ʻO ke kūlana o ka AMH, hiki i ke kauka wale nō ke hāʻawi i kahi loiloi piha o ke ʻano. Inā hoʻohaʻahaʻa ʻia ka mea hōʻailona, ʻo ka mea mua, pono ʻoe e ʻimi i ka ʻōlelo aʻoaʻo a kahi loea.