ʻO ka ʻoiaʻiʻo i ka wā e hiki mai ana e pau ka oncology i kahi ʻōlelo, ua hoʻomaka hou nā ʻepekema e kamaʻilio. Eia kekahi, ʻo ka mea i ʻike hou ʻia e nā mea noiʻi mai ke Kulanui o Notre Dame (South Bend, ʻAmelika Hui Pū ʻIa) e hōʻike ana he hiki ke holomua maoli i ka hoʻōla ʻana i nā ʻano maʻi ʻino loa o ka maʻi kanesa, he paʻakikī loa no nā lāʻau lapaʻau.
ʻO kahi hoʻolaha paʻi i kau ʻia ma ka pūnaewele Medical Xpress e kūkākūkā i nā waiwai kikoʻī o ka RIPK1 protein enzyme. ʻO ia kekahi o nā mea komo i ke kaʻina o ka necrosis cell. Eia naʻe, e like me ka ʻike ʻana o nā ʻepekema, hiki i kēia protein ke pale i ka hoʻomohala ʻana o nā neoplasms malignant a me ka hiki ʻana o nā metastases. ʻO ka hopena, hiki ke lilo kēia pūhui i hoʻokahi o nā ʻāpana o nā lāʻau lapaʻau i manaʻo ʻia no ka mālama ʻana i nā ʻano ʻoi loa o ka maʻi kanesa.
E like me ka mea i ʻike ʻia ma muli o ke aʻo ʻana, kōkua ʻo RIPK1 i ka hōʻemi ʻana i ka hele ʻana o ka mitochondria i nā cell. ʻO kēia nā organelles kuleana no ka hoʻokō ʻana i ka hoʻololi ikehu. I ka emi ʻana o kā lākou helu, hoʻomaka ka mea i kapa ʻia ʻo "oxidative stress". ʻO ka nui o nā ʻano oxygen reactive e hōʻino i nā protein, DNA a me nā lipids, ma muli o ka hoʻomaka ʻana o ke kaʻina o ka luku ʻana iā ia iho. I nā huaʻōlelo ʻē aʻe, hoʻomaka ke kaʻina hana o ka necrosis a i ʻole cell apoptosis.
Hoʻomaopopo ka poʻe ʻepekema ʻo ka necrosis kahi kaʻina pathological kahi i luku ʻia ai ke kelepona ponoʻī, a ʻo ka hoʻokuʻu ʻana o kāna mau mea i loko o ka intercellular space. Inā make ka cell e like me kāna papahana genetic, i kapa ʻia ʻo apoptosis, a laila e hoʻoneʻe ʻia kona koena mai ka ʻiʻo, kahi e hoʻopau ai i ka likelika o ka mumū.
Wahi a ka poʻe noiʻi ʻAmelika, hiki i ka RIPK1 ke lilo i hoʻokahi o nā catalysts no ka mea i kapa ʻia ʻo "controlled cell death". I nā huaʻōlelo ʻē aʻe, hiki ke hoʻohana ʻia ma ke ʻano he mea kaua o ka "point destruction" - e hoʻopili i nā "paʻi" i kuhikuhi ʻia i ka ʻōpū me kahi enzyme protein. E kōkua kēia i ka ho'ōki i ke kaʻina o ka metastasis a me ka hoʻonui ʻana i ka neoplasm.