I ka hapa nui o nā hihia (ʻoi aku ma mua o 95%), pili ka hypersecretion o ka hormone ulu e hoʻoulu ai i ka acromegaly i ka ulu ʻana o kahi maʻi pituitary benign (pituitary adenoma), kahi liʻiliʻi liʻiliʻi (e like me ka nui o ka chickpea), aia ma lalo. o ka lolo, e pili ana i ke kiekie o ka ihu.

Hiki pinepine kēia ʻōpū me ka manaʻo ʻole: a laila kūpono ʻia ʻo ia ma ke ʻano he "sporadic". I nā hihia ʻē aʻe, pili ʻia ka acromegaly i kahi anomaly genetic: aia kekahi mau hihia ʻē aʻe i loko o ka ʻohana a hiki ke pili pū me nā pathologies ʻē aʻe.

Eia nō naʻe, ʻoi aku ka paʻakikī o ka mālama ʻana ma waena o nā ʻano sporadic a me nā ʻohana, no ka mea, ma nā ʻano sporadic (me ka ʻole o nā hihia ʻē aʻe i loko o ka ʻohana), ua hiki ke hōʻike ʻia he mau genetic mutations kekahi. i ke kumu o ka mai.