ʻO Cushing's syndrome kahi maʻi endocrine e pili ana i ka hōʻike ʻana o ke kino i nā kiʻekiʻe kiʻekiʻe o cortisol, kahi hormone i hūnā ʻia e nā adrenal glands. ʻO kāna hiʻohiʻona ʻano nui ka momona o ke kino o luna a me ke alo o ka mea i hoʻopilikia ʻia. I ka hapa nui o nā hihia, hoʻokumu ʻia ʻo Cushing's syndrome e ka lawe ʻana i nā lāʻau anti-inflammatory. Akā hiki ke loaʻa iā ia ke kumu o ka hopena endogenous, e like me ka maʻi o Cushing, he kakaikahi loa ia, mai hoʻokahi a ʻumikūmākolu mau hihia hou i kēlā me kēia miliona mau kānaka a i kēlā me kēia makahiki, e like me nā kumuwaiwai. (1)

ʻO nā pae cortisol kiʻekiʻe kiʻekiʻe ma ka hopena o nā hōʻailona a me nā ʻōuli. ʻO ka mea nui loa ka loaʻa o ke kaumaha a me ka loli i ka helehelena o ka mea maʻi: hōʻiliʻili ka momona i ke kino o luna a me ka ʻāʻī, hele a puni ka maka, puffy a ʻulaʻula. Hele pū kēia me ka nalo ʻana o nā mākala i nā lima a me nā wāwae, i kahi mea hiki i kēia "atrophy" ke keʻakeʻa i ka neʻe o ke kanaka i hoʻopilikia ʻia.

ʻIke ʻia nā ʻōuli ʻē aʻe e like me ka lahilahi o ka ʻili, ke ʻano o nā kaha kau (ma ka ʻōpū, nā ʻūhā, ka ʻūhā, nā lima a me nā umauma) a me nā ʻūlū ma nā wāwae. ʻAʻole pono e mālama ʻole ʻia ka hōʻino psychological koʻikoʻi ma muli o ka hana cerebral o cortisol: ka luhi, ka hopohopo, ka huhū, ka hiamoe a me nā haunaele a me ke kaumaha e pili ana i ka maikaʻi o ke ola a hiki i ke ola.

Hiki i nā wahine ke hoʻomohala i ka huehue a me ka ulu nui o ka lauoho a ʻike i ka hoʻohaunaele menstruation, ʻoiai e hoʻoliʻiliʻi ka hana moekolohe a nā kāne. ʻO ka Osteoporosis, nā maʻi, ka thrombosis, ke koko kiʻekiʻe a me ka maʻi kō ka maʻi maʻamau.

Hoʻokumu ʻia ʻo Cushing's syndrome e ka hōʻike nui ʻana o nā pūnaewele i ke kino i nā steroid steroid, me ka cortisol. ʻO ka hopena o Cushing's Syndrome pinepine ka hopena mai ka lawe ʻana i nā corticosteroids synthetic no kā lākou hopena anti-inflammatory i ka mālama ʻana i ka hānō, nā maʻi ʻōpala, a me nā mea ʻē aʻe, ma ke ʻano he ʻehu a i ʻole he hamo. ʻO ia kahi kumu exogenous.

Akā hiki ke endogenous i kona kumu: a laila kumu ʻia ka maʻi e ka nui o ka huna ʻana o cortisol e hoʻokahi a i ʻole ʻelua mau adrenal (loaʻa ma ka piko o nā puʻupaʻa). Hana ʻia kēia i ka ulu ʻana o kahi tumo, ʻino a ʻino paha, i kahi gland adrenal, i ka pituitary gland (aia i ka iwi poʻo), a i ʻole nā ​​wahi ʻē aʻe o ke kino. Ke kumu ʻia ʻo Cushing's syndrome e kahi tumo benign i ka pituitary gland (kahi pituitary adenoma), ua kapa ʻia ʻo Cushing's disease. Hūnā ka tumo i ka nui o ka hormone korticotropin i ka ACTH e hoʻoulu ai i nā neʻe adrenal a i ʻole hoʻi i ka nui o ka huna ʻana o cortisol. ʻO ka maʻi ʻo Cushing no 70% o nā hihia endogenous āpau (2)

ʻO ka hapa nui o nā hihia o Cushing's syndrome ʻaʻole hoʻoilina. Eia nō naʻe, hiki i kēia ke hana ma muli o kahi predisposition genetical i hoʻoulu ʻia o nā tumors i ka endocrine, adrenal, a me nā pituitary glands.

ʻElima mau manawa ka ʻoi aku o nā wahine ma mua o nā kāne e loaʻa iā Cushing's syndrome i hoʻokumu ʻia e kahi adrenal a pituitary tumer. I kekahi ʻaoʻao, ʻekolu mau manawa ke hōʻike ʻia nā kāne ma mua o nā wahine ke kumu ʻo ka maʻi ʻaʻai māmā. (2)

ʻO ka pahuhopu o kēlā me kēia lāʻau lapaʻau no ka Cushing's syndrome e loaʻa hou ka kaohi o ka nui o ka huna o ka cortisol. Ke hoʻokomo ʻia ka maʻi ʻo Cushing's syndrome, hoʻoponopono kahi endocrinologist i ka lāʻau causal. Ke hopena ia o kahi tumo, hoʻohana ʻia e ka ʻoki (wehe ʻana i ka adenoma i ka pituitary gland, adrenalectomy, a me nā mea ʻē aʻe), radiotherapy a me chemotherapy. Ke hiki ʻole ke hoʻopau loa i ka tumo causative, hiki ke hoʻohana ʻia nā lāʻau e kāohi ai i ka cortisol (anticortisolics) a i ʻole nā ​​mea hoʻopale o ka hormone ACTH. Akā lahilahi lākou e hoʻokō a hiki i nā hopena ʻino ke koʻikoʻi, e hoʻomaka me ka makaʻu o ka adrenal insufffficient.