Le ʻO Gougerot-Sjögren Syndrome (e haʻi i ka sjeu-greunne), ʻo ia kahi ʻāpana o nā syndrome maloʻo, kahi kūlana mau o ke kumu autoimmune, ʻo ia hoʻi e pili ana i ka hopena o ka ʻōnaehana pale e kūʻē i kekahi mau mea o ke kino, i kēia hihia nā exocrine glands, e hūnā ana i nā wai i ka ʻili a i ʻole nā ​​membrane mucous.

ʻIke ʻia kāna ʻike i ka makahiki 1933, e D^r ʻO Henrik Sjögren, he ophthalmologist Kuekene.

Pili ʻia kona mau hiʻohiʻona i ka infiltration o kekahi glands e nā lymphocytes e hoʻoliʻiliʻi ana i kā lākou mau huna. ʻO nā aʻa salivary o ka waha a me nā lacrimal glands ka mea i laha pinepine ʻia, kuleana no ka "dry syndrome". Hiki iā mākou ke nānā i ka emi o ka hou, sebum akā ʻo ka infiltration a me ka mumū i nā mea ʻē aʻe e like me nā akemāmā, nā puʻupaʻa, nā hui a me nā moku liʻiliʻi.

ʻO Gougerot-Sjögren maʻi kahi maʻi laha ʻole e pili ana ma lalo o hoʻokahi ma 10 mau mākua. ʻOi aku ka nui o ka hopena o nā wahine ma mua o nā kāne. Kū pinepine ia ma kahi o 000 mau makahiki akā hiki ke hana ma mua ma kahi o 10 a 50 mau makahiki. 

ano

Hiki i ka maʻi ke hōʻike iā ia iho i nā ʻano 2:

• n. Hōʻike ka maʻi maʻi i kahi kaʻawale. ʻO kēia ka hihia 1 manawa ma 2. Ma kahi o 93% o ka poʻe i hoʻopilikia ʻia na wahine, a ʻike pinepine ʻia nā ʻōuli ma kahi o ka makahiki 50;
• Secondary. Pili ka maʻi maʻi i kekahi maʻi autoimmune ʻē aʻe, ʻo ka mea maʻamau ʻo ia ka rheumatoid arthritis.

Nā kumu

Ke kumu o ʻO Gougerot-Sjögren Syndrome ʻike ʻole ʻia. Eia nō naʻe, loaʻa nā maʻi mai kahi hopena autoimmune. Ke kumu o ka immune nenoaiu o ke kino e hana pono ʻole a hōʻeha i kāna mau pilikino ponoʻī. Ke nānā ʻia nei kekahi mau kuhiakau. Wahi a nā kānaka noiʻi, he koi paha ka hoʻomaka ʻana o kēia maʻi i nā mea ʻelua predisposition genetic a me ka hōʻea ʻana mai o nā kumu hoʻonāukiuki (maʻi viral, hoʻololi hormonal, stress, a pēlā aku.).

ka nā hōʻailona

I ka 2/3 o nā hihia hōʻike nā pilina i pili i ke komo ʻana o nā gland exocrine me ka pili o nā mea ʻē aʻe (kapa ʻia kēia he maʻi ʻōnaehana)

ʻO nā maka maloʻo a me ka waha ka mea maʻamau e hana. Eia naʻe, ʻike ʻia lākou ma hope no ka poʻe i loaʻa i ka maʻi mua. 

I nā maka, hiki i ka maloʻo ke kumu i ke ahi a i ʻole ka aniani. Hoʻopili pinepine nā maka maka i ke kakahiaka, a ʻoi aku ka maʻalahi o nā maka i ka mālam.

Hana ka waha maloʻo i ka ʻōlelo ʻana, ka nau ʻana a me ka ale ʻana i nā mea paʻakikī. 

Hiki iā mākou ke nānā i kahi mauʻu mau maloʻo mau, ʻeha pū, ʻeha ʻeha, luhi

Hiki ke paʻakikī ka sicca syndrome ma ka pae ocular e ka blepharitis a i ʻole keratitis a ma ka pae waha e ka hōʻino ʻana i nā gum, nā ʻūhaʻi, ka neʻe ʻana o nā niho, nā ʻeha ʻeha, nā maʻi ʻelua ma ka waha e ka mycoses. Hiki i kekahi ke nānā i kahi hypertrophy o nā parotid glands, kuewa a ʻaʻole paha.

ʻO nā hiʻohiʻona glandular keu e pili ana i nā hono (hoʻokahi i 2), Raynaud's syndrome (keʻokeʻo nā manamana lima i ka hopena o ke anuanu). ʻOi aku ka koʻikoʻi o nā hoʻouka ʻē aʻe akā ʻoi aku ka liʻiliʻi, ma ka pae pulmonary, renal, cutaneus a i ʻole ke aʻa. 

Laha loa ka luhi, a hele pū me ka ʻeha diffuse.

PalekanaEND_LINK

He paʻakikī ka hōʻailona no ka mea ʻaʻohe o ke kanaka nā hōʻailona āpau a pili paha kēia i nā ʻano ʻē aʻe a i ʻole ka mālama ʻana.

Pono nā hoʻokolohua like ʻole: e ʻimi i nā autoantibodies i ke koko (anti-SS-A, anti-SS-B antibodies), kahi loiloi o ka hana ʻana o nā lacrimal glands me ka hoʻohana ʻana i kahi pepa kānana (Schirmer's test), kahi nānā o ka membrane lahilahi. ka mea e uhi ana i ka maka i ke kala ʻana me ka bengal rose a me ka hoʻāʻo lawehala e loiloi ai i ka maloʻo o ka waha a me ka hōʻike ʻana o nā nodule lymphocytic ma kahi biopsy saliva; hana ʻia i loko o nā galo salivary waha, ʻaʻole ikaika loa kēia hana me ka ʻeha ʻole. Hoʻokumu ʻia ka hōʻailona ma ka hoʻohui ʻana o kahi helu o kēia mau hōʻailona maʻi a me nā meaola. 

Hōʻike paha ke kauka i ka kānana ʻana no nā wahi ʻē aʻe o ka maʻi a i ʻole nā ​​pathomy autoimmune ʻē aʻe.

I ka manawa o ke kuhi, ua nīnau ke kauka i ka mea maʻi e pili ana i kona kūlana olakino olakino, nā ʻano o nā lāʻau e lawe nei, a e pili ana hoʻi i ka papaʻai a me ka nui o ka wai a me nā wai ʻē aʻe i pau i kēlā me kēia lā.