ʻO kahi kumu pinepine no ka kūkākūkā ʻana, ʻo ka hyperandrogenism e pili ana i ka overproduction o nā hormones kāne i loko o ka wahine. Hōʻike ʻia kēia e nā hōʻailona o ka virilization.

I loko o nā wahine, hoʻopuka maoli nā ovaries a me nā ʻeleʻele adrenal i ka testosterone, akā ma ka liʻiliʻi. Loaʻa pinepine ia ma waena o 0,3 a me 3 nanomoles no ka lita o ke koko, i hoʻohālikelike ʻia me 8,2 a 34,6 nmol / L i nā kānaka.

Ke kamaʻilio nei mākou no ka hyperandrogenism ke kiʻekiʻe ke kiʻekiʻe o kēia hormone ma mua o ka maʻamau. Hiki ke ʻike ʻia nā hōʻailona o ka virilization: 

• hyperpilosité ;
• huehue;
• ʻōhule ;
• hypertrophy ʻiʻo, etc.

ʻAʻole aesthetic wale nō ka hopena. Hiki iā ia ke noʻonoʻo a me ka pilikanaka. Eia kekahi, hiki i ka overproduction o ka testosterone ke alakaʻi i ka infertility a me nā pilikia metabolism.

Hiki ke wehewehe ʻia e nā kumu like ʻole, ʻo ia ka mea maʻamau.

Ovarian dystrophy

Ke alakaʻi nei kēia i ka polycystic ovary syndrome (PCOS). Pili kēia ma kahi o 1 i 10 wahine. ʻIke nā poʻe maʻi i kā lākou pathology i ka wā ʻōpio, i ka wā e kūkākūkā ai lākou no kahi pilikia o ka hyperpilosity a me ka ʻeha nui, a i ʻole ma hope, ke kū nei lākou me ka infertility. ʻO kēia ke kumu o ka nui o ka testosterone i hana ʻia e nā ovaries e hoʻopau i ka hoʻomohala ʻana o nā follicles ovarian, ʻaʻole i oʻo pono e hoʻokuʻu i kā lākou mau hua. Hōʻike ʻia kēia e nā maʻi o ka menstrual cycle, a i ʻole ka nele o nā manawa (amenorrhea).

ʻO ka hyperplasia adrenal congenital

Ke alakaʻi nei kēia maʻi maʻi maʻamau i ka hana ʻino adrenal, me ka hoʻonui ʻana i nā hormones kāne a me ka underproduction o cortisol, kahi hormone e pāʻani nui i ka metabolism o nā carbohydrates, nā momona a me nā protein. I kēia hihia, hele pū ka hyperandrogenism me ka luhi, ka hypoglycemia a me ka hāʻule o ke koko. Hōʻike pinepine kēia pathology iā ia iho mai ka hānau ʻana, akā i kekahi mau hihia maʻalahi hiki ke kali a hiki i ka wā makua e hōʻike iā ia iho. 

ʻO kahi maʻi maʻi ma ka adrenal gland

Kakaʻikahi, hiki ke alakaʻi i ka huna nui ʻana o nā hormones kāne, akā pū kekahi cortisol. Hoʻopili ʻia ka Hyperandrogenism me ka hypercorticism, a i ʻole Cushing's Syndrome, kahi kumu o ka hypertension arterial.

He ma'i ovarian e huna ana i na hormones kane

He kakaikahi nae keia kumu.

Menopause

I ka emi ʻana o ka hana ʻana o nā hormones wahine, ʻoi aku ka nui o nā hormones kāne e hōʻike iā lākou iho. I kekahi manawa alakaʻi kēia i ka deregulation, me nā hōʻailona koʻikoʻi o ka virilization. ʻO ka hoʻokolohua lapaʻau wale nō e pili ana i kahi loiloi hormonal, me ka dosage o androgens, hiki ke hōʻoia i ka maʻi. Hiki ke kauoha ʻia kahi ultrasound o nā ovaries a i ʻole adrenal gland e wehewehe i ke kumu.

ʻO nā hōʻailona hōʻailona e hōʻike ana i ka hyperandrogenism penei:

• hulahula : he mea nui ka lauoho. ʻO ka mea nui, ʻike ʻia ka lauoho ma nā wahi o ke kino i ʻike ʻole ʻia i nā wahine (ka maka, ka ʻōpū, ka ʻōpū, ke kua lalo, ka ʻūhā, ka ʻūhā i loko), hiki ke loaʻa i kahi hopena noʻonoʻo a me ka pilikanaka. ;
• acne et ka seborrhée (ʻili ʻaila); 
• alopecia ʻōhule ma ke ʻano o ke kāne, me ka nui o ka pohō o ka lauoho ma ka piko o ke poʻo a i ʻole nā ​​poʻo poʻo mua.

Hiki ke pili pū kēia mau hōʻailona me:

• nā pilikia o ka pōʻaiapili kāne, me ka loaʻa ʻole o nā manawa (amenorrhea), a i ʻole ka lōʻihi a me nā pōʻai ʻole (spaniomenorrhea);
• ka hoʻonui ʻana i ka clitoral (clitoromegaly) a hoʻonui i ka libido;
• nā hōʻailona ʻē aʻe o ka virilization : hiki i ka leo ke lilo i mea koʻikoʻi a hoʻomanaʻo ka musculature i ka morphology kāne.

Ke hōʻailona nui ʻia, hiki i ka hyperandrogenism ke alakaʻi i nā pilikia lōʻihi ʻē aʻe:

• nā pilikia metabolic : ʻo ka hana nui ʻana o nā hormones kāne e hoʻoikaika i ka loaʻa ʻana o ke kaumaha a me ka hoʻomohala ʻana o ka insulin resistance, no laila ka pilikia o ka momona, ka maʻi diabetes a me ka maʻi cardiovascular;
• nā pilikia gynecological, me ka pi'i nui 'ana o ka ma'i 'a'ai endometrial.

ʻO kēia ke kumu ʻaʻole pono e noʻonoʻo ʻia ka hyperandrogenism mai kahi ʻano hoʻonaninani. Pono paha ia i ka mālama kino.

ʻO ka hoʻokele e pili mua i ke kumu.

I ka hihia o ke koko

Pono ka ʻoki ʻana e wehe.

No ka polycystic ovary syndrome

ʻAʻohe lāʻau lapaʻau e pale a hoʻōla i kēia maʻi, nā lāʻau lapaʻau wale nō no kona mau hōʻailona.

• Inā ʻaʻole hana ka mea maʻi a ʻoi aku paha nā keiki, ʻo ka mālama ʻana i ka hoʻomaha ʻana i nā ovaries, e hoʻemi i kā lākou hana ʻana i nā hormones kāne. Hoʻonohonoho ʻia kahi pilina estrogen-progestin. Inā ʻaʻole lawa kēia, hiki ke hāʻawi ʻia kahi lāʻau anti-androgen ma ke ʻano he mea hoʻohui, cyproterone acetate (Androcur®). Eia nō naʻe, no ka mea ua pili kēia huahana i kahi pilikia o ka maningioma, ua kaupalena ʻia kona hoʻohana ʻana i nā hihia koʻikoʻi loa, no ka maikaʻi o ka pono / pilikia;
• I ka makemake o ka hapai a me ka infertility, Hoʻoikaika maʻalahi ka hoʻoulu ʻana o ka ovulation e ka clomiphene citrate laina mua. Hana ʻia kahi loiloi infertility e hōʻoia i ka nele o nā kumu ʻē aʻe. Inā ʻaʻole hana ka hoʻoulu ʻana i ka lāʻau lapaʻau, a inā ʻike ʻia nā kumu ʻē aʻe o ka infertility, e noʻonoʻo ʻia ka insemination intrauterine a i ʻole in vitro fertilization. 

Hiki ke hāʻawi ʻia ka wehe ʻana i ka lauoho laser e hōʻemi i ka ulu ʻana o ka lauoho a me nā lāʻau dermatological kūloko e kūʻē i ka haki.

I nā hihia a pau, ʻōlelo ʻia ka hoʻomaʻamaʻa ʻana i kahi haʻuki a me ka hahai ʻana i ka meaʻai kaulike. I ka hihia o ke kaumaha, ʻo ka nalowale o ka 10% o ka paona mua e hōʻemi i ka hyperandrogenism a me nā pilikia āpau. 

I ka hihia o ka hyperplasia adrenal

Ke hoʻopaʻa ʻia ka maʻi, hoʻokomo ʻia ka mālama kikoʻī ma nā kikowaena loea i nā maʻi laha. ʻO ka lāʻau lapaʻau e pili ana i nā corticosteroids.