Ma 80% o nā maʻi, ʻike mua ʻia ka maʻi ma ke ʻano he nāwaliwali o ka ʻiʻo ma nā wāwae (= hāʻule wāwae) a me nā lima, a ukali ʻia e ka atrophy a me ka maʻi lolo. Hoʻopili ʻia ka nāwaliwali me nā ʻiʻo a me nā spasms, pinepine i nā lima a me nā poʻohiwi. He haʻalulu paha.

Ma hope o hoʻokahi a ʻelua paha makahiki o ka hoʻomohala ʻana, ʻike ʻia nā maʻi o ka komo ʻana o ka bulbar (i wehewehe ʻia ma lalo).

I loko o 20% o nā maʻi, hōʻike mua ka maʻi me nā hōʻailona o ka pōʻino i ka medulla oblongata, ʻo ia hoʻi ka paʻakikī o ka ʻōlelo (= paʻakikī i ka ʻōlelo ʻana, ka leo nāwaliwali, puʻupuʻu), i kapa ʻia ʻo dysarthria a me ka paʻakikī o ka nau a me ka ʻai ʻana (dysphagia). Ma hope mai, hōʻike nā maʻi me ka nāwaliwali o ka ʻiʻo o nā lālā a me ke kumu i hōʻike ʻia ma luna nei:

• Hoʻemi ka hoʻonohonoho ʻana a me ka dexterity
• Ka luhi nui
• ʻeleʻele
• Ka hoʻomau
• ʻEha, ʻoi aku ka ʻeha ʻiʻo
• ʻO Sialorrhée (hypersalivation)
• Pilikia hiamoe
• Paʻakikī i ka hanu ʻana, ma muli o ka piʻi ʻana o ka lolo o nā ʻiʻo hanu i loko o ka ʻōpū. Hiki mai kēia poino ma hope o ka wā o ka ma'i
• ʻO ka hōʻino ʻana o nā hana cognitive i hōʻike ʻia ma 30 a 50% o nā mea maʻi, ʻoi aku ka liʻiliʻi o nā loli i ke ʻano, irritability, obsessions, hoʻemi i ka hoʻohewa pilikino a me nā pilikia me ka hoʻonohonoho a me ka hoʻokō ʻana i nā hana. Ma kahi o 15% o nā hihia, aia ka dementia frontotemporal, me ka disorganization nui a me ka disinhibition.

Kanaka pilikia

Hoʻopilikia iki nā kāne ma mua o nā wahine.

Nā mea pilikino

Aia nā ʻano hoʻoilina o ka maʻi o Charcot (ma kahi o 10% o nā hihia). ʻO ka makahiki kekahi mea pilikia.