Contents
E like me kāna ʻoihana, hoʻoikaika ka Luna Hoʻoponopono o MedTvoiLokony i ka hāʻawi ʻana i nā ʻike olakino hilinaʻi i kākoʻo ʻia e ka ʻike ʻepekema hou loa. ʻO ka hae hou "Checked Content" e hōʻike ana ua loiloi a kākau pololei ʻia ka ʻatikala e ke kauka. ʻO kēia hōʻoia ʻelua ʻanuʻu: ʻo ka mea kākau moʻolelo olakino a me ke kauka e ʻae iā mākou e hāʻawi i ka ʻike kiʻekiʻe loa e like me ka ʻike olakino o kēia manawa.
Ua mahalo ʻia kā mākou kūpaʻa ma kēia wahi, a me nā mea ʻē aʻe, e ka Association of Journalists for Health, nāna i hāʻawi i ka Luna Hoʻoponopono o MedTvoiLokony me ka inoa hanohano o ka Luna Hoʻonaʻauao Nui.
ʻO ka maʻi o Alzheimer kahi maʻi neurodegenerative i hoʻopilikia pinepine ʻia i ka poʻe ʻelemakule. ʻO nā hōʻailona e pili ana i ka dementia holomua, nā pilikia hoʻomanaʻo, ka huhū a me ke ʻano o ka naʻau. ʻAʻole hiki ke hoʻōla ʻia ka maʻi o Alzheimer a hoʻokaʻawale pinepine i ka poʻe maʻi mai ka hana kūʻokoʻa.
ʻO nā kumu o ka maʻi o Alzheimer
Hoʻopili ʻia ka loaʻa ʻana o ka maʻi Alzheimer me nā ʻano like ʻole: genetic, environment, and mental (hoʻopaneʻe ka hana noʻonoʻo lōʻihi i ka maʻi). I kēia manawa, ʻaʻole i hoʻokumu ʻia ke kumu nui o ka maʻi o Alzheimer. Nui nā kuhiakau ʻepekema, me ka hoʻololi ʻana i ka DNA e hiki ke kōkua i ke ʻano o ka maʻi.
ʻO ka maʻi o Alzheimer ke kumu, inter alia, nā maʻi noʻonoʻo i loaʻa ma muli o ka haunaele i ka lawe ʻana i ka hōʻailona ma ka ʻōnaehana cholinergic o ka forebrain. ʻO kēia mau maʻi ka hopena ma muli o ka degeneration o nā neuron cholinergic (kuleana no ka nānā, hoʻomanaʻo). Hoʻopilikia ʻia nā neurons ʻē aʻe, ke kumu o ka manaʻo ʻole, ka hoʻopunipuni, ka huhū, a me ka hana ʻino.
ʻO ke ala o ka maʻi o Alzheimer
ʻO ke kumu nui o ka dementia i ka maʻi o Alzheimer ʻo ia ka pōʻino i nā neurons cholinergic, akā naʻe, ʻike ʻia nā waihona amyloid mua loa i nā neurons glutamatergic kuleana no ka excitatory transmission o ka lolo, aia i loko o ka entorhinal a me ka hui hui a me ka hippocampus. ʻO kēia mau hale lolo ke kuleana no ka hoʻomanaʻo a me ka ʻike. A laila, ʻike ʻia nā ʻōpala senile i loko o nā cholinergic a me serotonin fibers. Ke holomua nei ka maʻi, hoʻonui ka nui o nā waihona amyloid a alakaʻi i ka pau ʻana o nā neurons glutamatergic, cholinergic, serotonin a me nā noradrenergic neurons.
Hoʻomaka ka maʻi Alzheimer me ka ʻike ʻole ʻia a ʻaʻohe papa hana maʻamau. Noho ia mai 5 a 12 makahiki. ʻO nā hōʻailona mua ka hoʻomanaʻo a me ke ʻano o ka naʻau (ke kaumaha a me ka huhū waha-kino). A laila, piʻi aʻe nā pilikia me ka hoʻomanaʻo hou a me ka mamao, hiki ʻole ke hana kūʻokoʻa. Hoʻomaka ka poʻe maʻi o Alzheimer e loaʻa nā pilikia ʻōlelo, ʻoi aku ka nui o nā lāʻau lapaʻau a me nā hallucinations. I ka maʻi nui, ʻaʻole hiki i ka mea maʻi ke ʻike i kekahi, hoʻopuka i nā huaʻōlelo hoʻokahi, i kekahi manawa ʻaʻole ʻōlelo iki. ʻO ka maʻamau, hoʻopau ʻo ia i nā manawa āpau ma kahi moe a ʻaʻole hiki iā ia ke ʻai ma kāna iho. ʻO ka maʻamau, lilo ʻo ia i ka manaʻo ʻole, akā i kekahi manawa aia nā hōʻailona o ka hoʻonāukiuki.
Lapaʻau ʻana i ka maʻi o Alzheimer
I ka hōʻailona hōʻailona o Alzheimer, hoʻohana ʻia nā ʻano lāʻau like ʻole, e like me: nā lāʻau procognitive (hoʻomaikaʻi i nā mana cognitive), hoʻonui i ka metabolism o ka lolo, psychostimulating lāʻau, hoʻomaikaʻi i ka cerebral circulation, hoʻohaʻahaʻa i ke koko, anticoagulants, pale i ka cerebral hypoxia, nā huaora, anti-inflammatory. lāʻau lapaʻau, lāʻau psychotropic.
ʻO ka mea pōʻino, ʻaʻohe lāʻau lapaʻau i kūkulu ʻia no nā kumu o ka maʻi o Alzheimer. ʻO kekahi o nā kaʻina hana therapeutic maʻamau hoʻonui i ka maikaʻi o ka conductivity i ka ʻōnaehana cholinergic – i hoopilikia loa ia e keia mai.
ʻIke ʻia i ka makahiki 1986 mea ulu neuronal (NGF) Ua lawe mai ia i ka manaolana hou no ka puka ʻana mai o kahi lāʻau lapaʻau hou i nā maʻi neurodegenerative. Hoʻohana ʻo NGF i nā hopena trophic (hoʻomaikaʻi i ke ola) a me ka triopic (hoʻoulu i ka ulu ʻana) i nā hopena ma nā heluna neuronal he nui, e pale i ka hōʻino ʻana i nā pūnana nerve. Manaʻo kēia e hiki i ka NGF ke lilo i moho kūpono no ka mālama ʻana i ka maʻi o Alzheimer. ʻO ka mea pōʻino, he protein ʻo NGF ʻaʻole e hele i ka pale koko-lolo a pono e lawelawe ʻia i loko o ka cerebral. ʻO ka mea pōʻino, ʻo ka hoʻokomo pololei ʻana o NGF i loko o ka wai i loko o ka cerebral ventricles ke kumu i nā hopena koʻikoʻi
Manaʻo kekahi mau haʻawina nā mea mai ka hui o ka phosphodiesterase inhibitors he lāʻau maikaʻi paha ia i ka pale ʻana i ka ulu ʻana a me ka hōʻemi ʻana i nā hōʻailona o ka maʻi o Alzheimer. ʻO kahi hui o nā mea noiʻi ma Columbia University, alakaʻi ʻia e Ottavio Arancio a me Michael Shelanski, ua ʻike ʻo ka mālama ʻana me ka rolipram (hoʻohana ʻia ka lāʻau lapaʻau e mālama i ke kaumaha ma kekahi mau ʻāina) e hoʻomaikaʻi i ka hoʻomanaʻo a me ka cognition. Eia kekahi, ʻaʻole maikaʻi kēia lāʻau lapaʻau i ka wā mua o ka maʻi, akā i nā poʻe me ka maʻi Alzheimer kiʻekiʻe. ʻO Rolipram kahi mea pale phosphodiesterase. ʻO ka Phosphodiesterase ke kuleana no ka haki ʻana o ka molekele hōʻailona cAMP, kahi e hoʻoulu ai i ka ulu ʻana o ka ʻiʻo hopohopo. Kāohi ʻo Rolipram i ka haki ʻana o ka cAMP ma ke kāohi ʻana i ka hana phosphodiesterase, ka mea e hōʻiliʻili ai ka cAMP i loko o ka ʻiʻo nīnū i hōʻino ʻia. ʻO ka hopena, hiki ke hana ʻia nā kaʻina hana e hoʻolaʻa hou i nā pūnaewele nerve i pōʻino.
Ma ka hoʻohana ikaika ʻana i ka lolo, pale mākou iā ia mai nā kaʻina neurodegenerative a i ka manawa like e hoʻoulu ai i ka neurogenesis, a laila e hoʻolōʻihi i ka ʻōpio o ko mākou noʻonoʻo a hoʻonui i nā manawa kūpono e noho kūpono no ke koena o ko mākou ola. No laila, ʻaʻole i hoʻohālikelike ka noʻonoʻo i ko mākou ola wale nō, akā i ko mākou olakino.
E heluhelu hou aʻe e pili ana i kahi meaʻai palekana no Alzheimer!
Kikokikona: Krzysztof Tokarski, MD, PhD, mea noiʻi ma ka Institute of Pharmacology o ka Polish Academy of Sciences ma Krakow
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