Hoʻohui pū ka huaʻōlelo "collagenosis" i kahi maʻi o nā maʻi autoimmune i hōʻike ʻia e ka hōʻino kino a me ka immunological i nā mea hoʻopili, hyperactivity o ka ʻōnaehana pale, kahi predominance o nā wahine, hui pū me nā antinuclear antibodies a me ka hoʻolaha ʻana o nā leona. Aia nā mea hoʻopili i loko o ke kino, hiki ke hoʻopili ʻia nā mea āpau i kahi ʻano ʻoi aku a i ʻole pili, no laila ke ʻano nui o nā ʻōuli i hopena ʻia mai collagenosis. ʻO ka pahuhopu o kā lākou hoʻokele ka mālama ʻana i ka hana maʻi a hoʻemi iā ia i kahi pae haʻahaʻa loa.

ʻO Collagenoses, i kapa ʻia hoʻi he connectivitis a i ʻole nā ​​maʻi ʻōnaehana, hui pū kekahi i kahi maʻi maʻi maʻi autoimmune maha mau loa, i hopena ʻia mai nā collagen abnormal i nā pūnaewele i waiwai i nā matrix intercellular, ʻo ia hoʻi nā mea hoʻopili.

ʻO Collagen ka protein i loko o ko mākou kino. ʻAe ia i ko mākou kino a me ko mākou kino e kūpaʻa me ka ʻole o ka ʻoʻoleʻa, ʻoiai hiki ke loli. Hūnā ʻia e nā pūnaewele pūnaewele hoʻopili, hoʻopili pū ka collagen me kahi nui o nā mole ʻē aʻe e hana i nā olonā a hana i nā kiko fibrous me nā mea kākoʻo a me nā kū paʻa.

ʻO Promininant i nā wahine, hiki i nā collagenases ke hōʻea i nā ʻōnaehana āpau (ʻōnaehana digestive, nā mākala, nā hono, ka puʻuwai, nā ʻōnaehana). ʻO kēia ke kumu o ka nui o kāna mau hōʻike e like me ka nui o nā mea i hoʻopili ʻia. ʻO ka maikaʻi o ke ola i kekahi manawa ka hopena ikaika loa. Pili ka hopena o kēia mau maʻi i ka hōʻino ʻana i nā mea ola.

ʻO ka collagenosis kaulana loa ka ʻōnaehana lupus erythematosus (SLE). Hoʻopili pū ʻia ʻo Collagenosis i nā maʻi aʻe:

• rheumatoid arthritis;
• oculourethro-synovial Syndrome (OUS);
• spondyloarthropathies (ʻoi aku ka ankylosing spondylitis);
• Maʻi ʻo Horton;
• Wegener's granulomatose;
• rhizomelic pseudo-polyarthritis;
• scleroderma;
• maʻi ʻōnaehana huikau a i ʻole Sharp Syndrome;
• la microangiopathie thrombotique;
• periarteritis nodosa;
• ka maʻi Gougerot-Sjögren;
• dermatomyositis;
• dermatopolymyositis;
• Maʻi ʻo Behçet;
• ka sarcoïdose;
• histiocytosis;
• Maladie nō naʻe;
• maʻi kūlohelohe;
• overload nā maʻi a me kekahi metabolic maʻi;
• maʻi maʻi akepaʻa;
• nā maʻi o nā mea lahilahi;
• nā maʻi kūlohelohe a i ʻole loaʻa i ka serum kōkua;
• scleroderma;
• Maʻi Churg-Strauss;
• ʻōnaehana vasculitis, etc.

ʻAʻole ʻike ʻia lākou. Aia paha he maʻi o ka ʻōnaehana paleʻea, e like me ka mea i hōʻike ʻia i loko o ke koko o nā mea maʻi, ke kū ʻana o nā mea ʻino ʻino, i kapa ʻia he autoantibodies a i ʻole nā ​​anti -uclear antibodies, i kuhikuhi ʻia e kūʻē i nā mea ponoʻī o nā kino o ke kino. ʻIke ʻia kekahi mau antigens o ka ʻōnaehana histocompatibility (HLA) i kekahi mau maʻi, a i ʻole ma kekahi mau ʻohana i pili pinepine ʻia, e hōʻike ana i ka paipai ʻana i ka hana o ka genetic factor.

Aia nā mea hoʻopili i loko o ke kino, e hoʻopili ʻia nā mea āpau i kahi ala ʻoi aku a i ʻole pili, no laila nā ʻano like ʻole o nā ʻōuli i hiki ke hopena ʻia mai nā hoʻouka ʻana.

• haʻi ʻōlelo;
• ʻākalaʻai;
• puʻuwai puʻuwai;
• pulmonary;
• hepaʻa;
• ʻākala:
• nā aʻalolo waena a ākea paha;
• vaskular;
• ʻūlū kino

Lawe pinepine ka loli o collagenosis i ke ʻano o ka hoʻi hou e pili pinepine ʻia me kahi maʻi palupalu a he loli nui ia pākahi. ʻIke ʻia nā ʻōuli kikoʻī ʻole i nā kekelē ʻokoʻa.

• wela (fever fever);
• hoʻohaʻahaʻa;
• luhi mau loa;
• hoʻemi i ka hana;
• paʻakikī paʻakikī e noʻonoʻo ana;
• ʻike i ka lā a me ka mālamalama;
• alopecia;
• ʻike i ke anuanu;
• maloʻo nasal / oral / vaginal;
• nā maʻi ʻili;
• Kaumaha emi ;
• ʻeha pū;
• ʻehaʻeha o nā mākala (myalgia) a me nā hono (arthralgia).

I kekahi manawa ʻaʻohe hōʻailona o nā mea maʻi ma mua o ka ʻeha hui a me ka luhi. A laila kamaʻilio mākou e pili ana i ka connectivitis i hoʻokaʻawale ʻole ʻia. I kekahi manawa ʻike ʻia nā ʻōuli o nā ʻano ʻano like ʻole o nā maʻi pilina. Kapa ʻia kēia he maʻi overlap.

Ma muli o ka hiki no ka nui o nā poho o ke kino, he mea nui e pili like nā ʻāpana lapaʻau ʻokoʻa. Hoʻokumu ʻia ke kuhi ma ka mōʻaukala, ʻo ia ka mōʻaukala o ka mea maʻi, a me kāna hoʻokolohua hoʻokolohua, e ʻimi ana i nā ʻōuli i loaʻa pinepine i hoʻokahi a ʻoi paha o kēia mau maʻi.

ʻOiai ke ʻano o nā collagenases e ka nui o ka antinuclear antibody production, ʻo ka hoʻāʻo ʻana no kēia mau autoantibodies i ke koko he mea nui i ka hoʻokumu ʻana i kahi kuhi. Eia naʻe, ʻaʻole kūlike ka hiki ʻana o kēia mau autoantibodies me collagenase. I kekahi manawa pono nō hoʻi ia e lawe i kahi laʻana kikoʻī a i ʻole biopsy. Paipai ʻia ka hāʻawi ʻana i ka loea e hōʻoia i ka hōʻailona a hoʻomaka i ka lāʻau kūpono.

ʻO ka pahuhopu o ka mālama ʻana i collagenosis ka mālama ʻana i ka hana maʻi a hoʻemi iā ia i kahi pae haʻahaʻa loa. Hoʻomaʻamaʻa ʻia ka lāʻau e like me ke ʻano o ka collagenosis i ʻike ʻia a e like me nā ʻāpana i hoʻopili ʻia. Hoʻohana pinepine ʻia ʻo Corticosteroids (cortisone) a me nā analgesics e like me ka laina mua e hoʻōki i nā hoʻi hou ʻana a hoʻomalie i nā hōʻike ʻeha. ʻO ka hoʻohui o kahi immunosuppressant, e ka waha a i ʻole ke kuʻi ʻana, pono paha. Hoʻokomo pū paha ka hoʻokele i nā injection intravenous o immunoglobulins a i ʻole nā ​​hana hoʻomaʻemaʻe plasma (plasmapheresis) i kahi kauka. ʻO kekahi mau mea maʻi, e like me nā mea me ka lupus, loaʻa paha iā lākou ka pōmaikaʻi mai ka mālama antimalarial.