Le fibrinogen he kumuʻiʻo koko e paʻa ana i loko coagulation. Komo 'o ia i ke a'o 'ana o koko clots a hoʻololi pū i ka hana o nā platelets koko a aeea o ka nā moku. Ma lalo o ka hana a kekahi protein, ka thrombin, lilo ia i fibrin

Hoʻohui ʻia ia e nā ʻāpana o ke ake. ʻO kona kiʻekiʻe i loko o ke koko e ʻokoʻa mai ka 2 a 4 g / l. Eia naʻe, ka synthesis o kēia kumuʻiʻo hiki ke hoʻonui ma muli o ke koʻikoʻi, i ka wā hāpai, a i ʻole ma hope o ke kau ʻana i kekahi mau lāʻau a i ʻole ka hormone ulu. ʻO ka piʻi ʻana o ke kiʻekiʻe o ka fibrinogen i loko o ke koko e hōʻike ana i kahi maʻi inflammatory.

Hōʻike ʻia ka fibrinogen assay no ka nānā ʻana no kahi maʻi hoʻopaʻa koko (no ka laʻana inā he koko i wehewehe ʻole ʻia a i ʻole " defibrination syndrome », E pili ana i kahi ʻano ʻino coagulation).

Aia ʻekolu mau hemahema hānau ma nā pae fibrinogen:

• THEafibrinogenemia, ʻo ia ka nele loa o ka fibrinogen. ʻO kēia maʻi kakaʻikahi ke kumu o ke koko nui mai ka hānau ʻana
• THEhypofibrinogenemia, pili i ka emi ʻana o ke kiʻekiʻe o ka fibrinogen i loko o ke koko (he hemahema kēia i ka huna huna, pinepine pinepine)
• La dysfibrinogenemia, he mea ʻino ia o ka protein.

Hiki ke hoʻohana ʻia ka hoʻokolohua fibrinogen koko i nā hihia o:

• maʻi nā maʻi kani
• ʻo ka hemahema o ka ate (e alakaʻi ana i ka emi ʻana o nā pae fibrinogen)
• e nānā i ka hopena o kahi lāʻau i kapa ʻia ʻo "fibrinolytic", i manaʻo ʻia e hoʻopau i kahi koko koko i ka wā o ka thrombosis.

ʻO keʻano o fibrinogen hana ʻia ma kahi hōʻike koko venous (hoʻāʻo koko), i loko o kahi keʻena hoʻokolohua lapaʻau. He ana maʻamau ka dosage a loaʻa mau nā hopena i loko o ka lā.

ʻO ke kauka wale nō ka mea hiki ke wehewehe i nā hopena o ka nānā ʻana.

ʻO ka maʻamau, ʻoi aku ka nui o ka fibrinogen (hyperfibrinogenemia) hiki ke nānā ʻia i ka hihia o ka mumū, i ka hihia o kekahi mau maʻi infectious (pneumonia, etc.), i ka hihia o ka rheumatic fever a i ʻole nā ​​maʻi autoimmune (lupus), ma hope o ka myocardial infarction, etc.

ʻO ka mea ʻē aʻe, hiki i ka hypofibrinogenemia (hōʻemi i ka pae fibrinogen) ke hōʻike i kahi maʻi genetic, hiki ʻole i ka ate koʻikoʻi (hepatitis, cirrhosis), nā maʻi coagulation (disseminated intravascular coagulation or defibrination syndrome) a i ʻole "fibrinolysis", no ka laʻana ma muli o ke kanesa.