I nā kāne a me nā wahine, ʻo ka luteinizing hormone a i ʻole LH ke kuleana nui i ka ulu. He ʻāpana ʻoiaʻiʻo ia o nā hormones i kapa ʻia ʻo gonadotropins, nā alakaʻi o nā ʻōpū hānau. No laila, ʻo kahi maʻi i loko o kāna huna ʻana he mea keakea ia i ka hāpai ʻana.

Luteinizing hormone a i ʻole LH (luteizing hormone) ua huna ʻia e ka pituitary anterior. He ʻāpana ia o nā gonadotropins: hoʻokele ʻo ia, me nā hormones ʻē aʻe, nā kelepa wahine (gonads), i kēia hihia i nā ovaries i nā wahine a me nā testes i nā kāne.

I nā wahine

Me ka follicle stimulating hormone (FSH), he koʻikoʻi ko LH i ka pōʻai ovarian. ʻO ia ka LH piʻi e hoʻoulu ai i ka ovulation i ka wā o ke ʻano o nā hopena kaulahao:

• huna ka hypothalamus i ka gnRH (ka hormone hoʻokuʻu gonadotrophin) ka mea e hoʻoulu ai i ka pituitary gland;
• i ka pane, huna ka pituitary gland i ka FSH i ka manawa mua o ka pōʻai (mai ka lā mua o ka menstruation a i ka ovulation);
• Ma lalo o ka hopena o FSH, e hoʻomaka ana kekahi mau follicle ovarian e oʻo. ʻO nā pūnaewele ovarian e pili ana i nā follicles ovarian e oʻo ana e hūnā i ka nui o ka estrogen;
• ʻO kēia hoʻonui i ke kiʻekiʻe o ka estrogen i loko o ke koko e hana i ka paʻakikī hypothalamic-pituitary a ke kumu i ka hoʻokuʻu nui ʻana o LH;
• ma lalo o ka hopena o kēia piʻi ʻana o ka LH, piʻi ka haʻalulu i ka follicle. Nahā ia a kipaku aku i ka oocyte i loko o ka paipu: ʻo ia ka ovulation, e hana ʻia ma 24 a 36 mau hola ma hope o ka piʻi ʻana o ka LH.

Ma hope o ka ovulation, hoʻomau ka LH i ka hana koʻikoʻi. Ma lalo o kona mana, hoʻololi ʻia ka follicle ovarian i ʻoki ʻia i loko o ka ʻili i kapa ʻia ʻo ka corpus luteum e hūnā i ka estrogen a me ka progesterone, ʻelua mau hormones pono i ka wā hāpai mua.

I ke kanaka

E like me nā ovaries, aia nā hōʻailona ma lalo o ka mana o FSH a me LH. Hoʻoulu ka mea hope i nā pūnaewele Leydig i kuleana no ka huna ʻana o ka testosterone. He mau ka LH huna ma hope o ka wā ʻōpio.

Hiki ke kuhikuhi ʻia ka dosage LH i nā kūlana like ʻole:

I nā wahine

• i mua o nā hōʻailona o ka wā ʻōpio mua a i ʻole ka wā ʻōpio;
• inā loaʻa nā pilikia menstruation;
• inā pilikia ka hāpai ʻana: hoʻokō ʻia ka loiloi hormonal ma ke ʻano he ʻāpana o ka loiloi infertility. Loaʻa iā ia ka hoʻoholo ʻana o LH;
• ʻO ka ʻike ʻana i ka piʻi ʻana o ka LH i loko o ka mimi e hiki ai ke hoʻomaopopo i ka lā o ka ovulation, a no laila e hoʻoholo ai i kona puka makani momona i mea e hoʻonui ai i kona manawa o ka hāpai ʻana. ʻO kēia ke kumu o nā hoʻokolohua ovulation i kūʻai ʻia ma nā hale kūʻai;
• ma kekahi ʻaoʻao, ʻaʻohe hoihoi o ka LH assay i ka ʻike o ka menopause (HAS 2005) (1).

I ke kanaka

• i mua o nā hōʻailona o ka wā ʻōpio mua a i ʻole ka wā ʻōpio;
• inā pilikia ka hāpai ʻana: hoʻokō ʻia ka loiloi hormonal i nā kāne. Loaʻa iā ia ka LH assay.

Hoʻāʻo ʻia ʻo LH mai kahi hoʻāʻo koko maʻalahi. I nā wahine, hana ʻia ia ma ka lā 2nd, 3rd a i ʻole 4th o ka pōʻai i loko o kahi keʻena reference, i ka manawa like me ka FSH a me ka estradiol assays. I ka hopena o ka amenorrhea (ka ʻole o nā manawa), hiki ke lawe ʻia ka hāpana i kēlā me kēia manawa.

Ma ka pōʻaiapili o kahi hōʻailona o ka wā ʻōpio a i ʻole ka wā ʻōpio i loko o kahi kaikamahine ʻōpio a i ʻole keikikāne, e makemake ʻia ka nui o ka mimi. Hoʻopili ʻia nā gonadotropins FSH a me LH ma ke ʻano pulsatile i ka wā ʻōpio a ua hoʻopau ʻia i loko o ka mimi. No laila, hiki i ka urinary dosage ke hiki ke loiloi maikaʻi i nā pae huna ma mua o ka dosage serum punctual.

I nā keiki

Hiki i nā pae kiʻekiʻe o FSH a me LH ke hōʻailona o ka wā ʻōpio mua.

I nā wahine

Ma keʻano hoʻolālā, ʻO ka pae LH kiʻekiʻe e alakaʻi i kahi hemahema o ka ovarian mua (he pilikia me nā ovaries ponoʻī ke kumu o ka lawa ʻole o ka gonadal) ma muli paha o:

• he anomaly congenital o nā ovaries;
• he chromosomal abnormality (Turner syndrome ka nui);
• ka lapaʻau ʻana a i ʻole ka ʻoki ʻana i pili i ka hana ovarian (chemotherapy, radiotherapy);
• ʻO ka maʻi maʻi polycystic ovary (PCOS):
• ka maʻi thyroid a i ʻole ka maʻi adrenal;
• he puu ovarian.

ʻO ka mea like ʻole, hiki i kahi pae LH haʻahaʻa ke alakaʻi i kahi maʻi ovarian lua o ke kumu kiʻekiʻe (hypothalamus a me pituitary) alakaʻi i kahi hemahema o ka hoʻoulu ʻana i ka gonadal. ʻO kekahi o nā kumu maʻamau ka prolactin pituitary adenoma.

I ke kanaka

ʻO ke kiʻekiʻe kiʻekiʻe o ka LH e kuhikuhi i ka hōʻoia i ka hemahema testicular mua ma muli paha o:

• he chromosomal abnormal;
• ka nele o ka hoʻomohala ʻana o nā hōʻike (testicular agenesis);
• ʻehaʻeha testicular;
• he maʻi maʻi;
• ka mālama ʻana (radiotherapy, chemotherapy);
• he koko koko;
• he maʻi autoimmune.

Hoʻi ka pae LH haʻahaʻa i kahi maʻi o ke kumu kiʻekiʻe, i loko o ka pituitary a me hypothalamus (pituitary tumor no ka laʻana) e alakaʻi ana i ka hemahema testicular lua.