Hōʻike ʻia ʻo Macrophage myofasciitis e nā maʻi histopathological (maʻi e pili ana i nā ʻiʻo). ʻO kēia nā hopena myopathological, ʻo ia hoʻi ka hopena i ka ʻiʻo ʻiʻo.

Ua wehewehe ʻia kēia maʻi ma hope o kahi biopsy kanaka, mai kahi maʻi makua a ma 3 mau keiki. Ua hōʻike ʻia ka pōʻino i loko o nā ʻiʻo ʻiʻo me ka ʻole o ka necrosis. ʻO ka nānā ʻana i kēia mau ʻeha (nā microprobes nuklea, radiographic microanalyses, atomic absorption spectrometry) i hiki ke hoʻomaopopo ʻia ua haku ʻia kēia pōʻino i nā paʻakai alumini. Hoʻohana nui ʻia kēia mau mea i ka nui o nā lāʻau lapaʻau i lawelawe ʻia ma ka intramuscularly. Ua hōʻike ʻia hoʻi ʻaʻohe kumu kumu o ka maʻi. ʻOiaʻiʻo, hiki i ka poʻe olakino (ʻaʻole maʻi, loaʻa ke ola olakino, a me nā mea ʻē aʻe) hiki ke hoʻopilikia ʻia e ka maʻi ma hope o ka hoʻopaʻa ʻana. (1)

I ka wā mua, ʻaʻole ʻike ʻia ke kumu maoli o ka maʻi. Ua hoʻāla ʻia nā kānalua e pili ana i kahi kaiapuni, infectious a me nā kumu ʻē aʻe. ʻO ka hana ʻepekema i hana ʻia ma waena o 1998 a me 2001 ua hoʻoholo ʻo ke kumu maoli o ka maʻi ʻo ka absorption o ka alumini hydroxide i loaʻa i nā lāʻau lapaʻau. Nā hōʻike kiʻi kiʻi microscopic o nā mea i loko: ua hōʻike nā macrophages i ka noho mau o nā inclusions i hana ʻia e kēia mau paʻakai alumini. Hoʻohana ʻia kēia mau pūhui ma ke ʻano he adjuvants i nā lāʻau lapaʻau. Loaʻa ka macrophage myofasciitis wale nō ma ka deltoid i nā pākeke a ma nā quadriceps i nā keiki.

ʻO nā hōʻailona nui e pili ana i ka maʻi penei:

- ʻeha mau i loko o nā ʻiʻo: ʻoi aku ka lohi o ka ulu ʻana (ma kahi o kekahi mau mahina). Hoʻopili kēia mau hōʻailona ma waena o 55 a 96% o nā maʻi i loaʻa i ka maʻi. Ua hōʻike ʻia ka ulu ʻana o kēia mau hōʻike lapaʻau ma kahi mamao mai nā iwi ʻaoʻao liʻiliʻi a pālahalaha mālie i ke kino holoʻokoʻa. No ka liʻiliʻi o nā maʻi, alakaʻi kēia ʻeha ʻeha i nā pilikia hana. Eia kekahi, ʻike pinepine ʻia ka ʻeha ma ka iwi kuamoʻo. ʻIke pinepine ʻia kēia mau ʻeha i ka wā e ala ai ke kanaka a hoʻokiʻekiʻe ʻia i ka wā hoʻoikaika kino a me nā hana o kēlā me kēia lā;

- ka luhi mau loa, e pili ana ma waena o 36 a me 100% o nā maʻi. ʻO kēia luhi nui ka mea maʻamau i ka emi ʻana o nā hana a ke kanaka i kēlā me kēia lā, ma ka noʻonoʻo a me ke kino;

- nā abnormalities cognitive, nā hopena i mālama ʻole ʻia i ka maʻi. ʻO kēia mau hiʻohiʻona ka hopena i ke kaumaha, ka emi ʻana o ka cognitive a me ka hana naʻauao, nā maʻi nānā, etc.

Hiki ke hui pū ʻia nā hōʻailona ʻē aʻe me ka maʻi. Hoʻopili kēia i nā hōʻike psychiatric, ʻoi aku ka maʻi o ka naʻau.

Ua hōʻike pū ʻia ka dyspnea (ka hanu pilikia) a me ke poʻo i kekahi mau maʻi.

ʻO ke kumu o ka maʻi ʻo ka hele ʻana o ka alumini hydroxides i nā lāʻau lapaʻau i hoʻopaʻa ʻia i loko o nā maʻi ma ke ala intramuscular.

Hoʻopilikia ka Macrophage myofasciitis i nā kāne a me nā wahine, nā mākua a me nā keiki, me ka ʻole o ke ʻano kumu, ma hope o ka hoʻopaʻa ʻana. Hoʻopilikia pinepine ʻia nā pākeke ma hope o ka lāʻau lapaʻau i loko o ka deltoid, aʻo nā keiki e pili ana ma hope o ka hoʻopaʻa ʻana i nā quadriceps.

ʻO nā lāʻau lapaʻau i hoʻopilikia nui ʻia e ka loaʻa ʻana o nā paʻakai alumini ma ke ʻano he adjuvant:

1. ka ma'i hepa B: 84%;

2. ka ma'i tetanus: 58%;

3. kaʻi kū'ē i ka hepatitis A: 19%.

Eia kekahi, ua hōʻike ʻia ka hoʻomau ʻana o ka paʻakai alumini i ke kino. A i ʻole ka ʻike ʻia ʻana o kahi biopsy ʻiʻo ʻiʻo e hiki ke hōʻike i ka loaʻa ʻana o kēia mau pūhui nona ke kumu he kano i hoʻomaka i nā makahiki he nui. (3)

Me he mea lā aia nā predispositions i kekahi poʻe, ʻaʻole e ʻae iā lākou e hoʻopau pono i nā paʻakai alumini i loaʻa i nā lāʻau lapaʻau a ma kēia ʻano, ʻike lākou e hōʻiliʻili i loko o ka ʻiʻo ʻiʻo.

ʻAʻole i hōʻike maopopo ʻia nā kumu pilikia pilikino no ka ulu ʻana o ka maʻi.

Ua hōʻike ʻia kahi loulou ma waena o nā hōʻailona ʻōnaehana a me ka ulu ʻana o ka maʻi ma kahi hapa liʻiliʻi o nā hihia o ka myofasciitis macrophage.

Eia kekahi, ua hoʻopiʻi ʻia nā genetic predispositions, ʻoi loa i nā hihia pinepine o ka maʻi i loko o nā kaikunāne hoʻokahi. Ua hōʻike ʻia kekahi mau noiʻi ʻepekema hiki i kahi hoʻoilina genetic ke loaʻa ka hopena i ka hoʻomau ʻana o nā paʻakai alumini i loko o ka ʻiʻo ʻiʻo. Hōʻike ʻia ka pathology e ka hoʻonui ʻana i ka CCL2 / MCP-1, kahi cytokine i komo i ke komo ʻana o nā nanoparticles i ka lolo. ʻO nā hoʻololi genetic i nā genes e hoʻopili ana i kēia mole ke lilo i mea pilikia hou no ka hoʻomohala ʻana i ka maʻi.

Hana ʻia ka ʻike o ka maʻi e like me nā hōʻailona maʻi ʻē aʻe a i ʻole ka liʻiliʻi. ʻOiaʻiʻo, pili ka mea mua i ka loaʻa ʻana o nā paʻakai alumini, mai kahi maʻi kano, i loko o ka ʻiʻo ʻiʻo.

Eia kekahi, ʻo ka hele ʻana o ka myalgia (ʻeha ʻeha) i ka deltoid e pili ana me ka ʻike ʻana o nā hydroxides alumini i loko o kēia kiko, a me nā hōʻike o ka ulu ʻana o ka pathology i nā pākeke.

ʻO ka hoʻoholo ʻana i nā hōʻike lapaʻau (ka ʻeha ʻeha o ka ʻiʻo, ka luhi mau a me nā mea ʻino ʻole o ka cognitive) e hiki ai ke hoʻokumu a ʻaʻole ʻole ka maʻi o ka maʻi.

ʻO kahi hōʻailona maikaʻi o ka maʻi e pili ana i ka ʻike ʻana i nā ʻeha i nā macrophages deltoid i nā pākeke a me nā quadriceps i nā keiki.

I ka 1/3 o nā hihia, ʻo ka piʻi ʻana o ke kiʻekiʻe o ka plasma creatine kinase ke ʻano o ka pathology. Eia nō naʻe, hiki ke hoʻopili ʻia kēia pae cytokine kiʻekiʻe loa me nā maʻi ʻē aʻe a i ʻole nā ​​​​maʻi ʻōnaehana pale. Ma kēia ʻano, pono e hoʻokō ʻia nā hoʻokolohua hou e hoʻopau i nā kānalua no kekahi kumu ʻē aʻe.

ʻO ka electrodiagnosis, MRI (Magnetic Resonance Imaging) o nā ʻiʻo i hiki ke ʻae a ʻaʻole paha i nā manaʻo mua.