ʻO ka Serum protein electrophoresis kahi hoʻokolohua i hana ʻia mai kahi hoʻāʻo koko e hiki ai ke ʻike a me ka nānā ʻana i nā maʻi he nui e like me monoclonal immunoglobulin, hypergammaglobulinemia a ʻoi aku ka paʻakikī hypogammaglobulinemia.

ʻO ka Serum protein electrophoresis (EPS) kahi hoʻokolohua olakino olakino. ʻO kāna pahuhopu ka hoʻokaʻawale ʻana o nā protein i loko o ka ʻāpana wai o ke koko (ka serum). "Ke hana nui nei kēia mau protein i ka lawe ʻana i nā molekole he nui (hormones, lipids, lāʻau lapaʻau, etc.), a pili pū kekahi i ka coagulation, immunity a me ka mālama ʻana i ke koko. ʻO kēia kaʻawale ka mea e hiki ai ke hoʻomaopopo a hoʻohālikelike iā lākou ", ʻōlelo ʻo Dr Sophie Lyon, ka mea ola kino.

Ka hoʻopili ʻana i ka protein

Ma hope o ka hoʻāʻo ʻana i ke koko, ʻike ʻia nā protein e ka neʻe ʻana i kahi kahua uila. "A laila hoʻokaʻawale lākou e like me kā lākou uila uila a me ko lākou kaumaha molekala, kahi e hiki ai ke ʻike iā lākou a ʻike i nā anomalies." E ʻae ʻo EPS i ka hoʻokaʻawale ʻana o nā hakina protein ʻeono, i ka hoʻohaʻahaʻa ʻana i ka wikiwiki o ko lākou neʻe ʻana: albumin (ʻo ia ka protein serum nui, ma kahi o 60%), alpha 1-globulins, alpha 2-globulins, Beta 1 globulin, Beta 2 globulin a me gammaglobulins. "Hiki i ka Electrophoresis ke ʻike i kekahi mau maʻi e pili ana i ka hana maikaʻi ʻole o ke ake a i ʻole nā ​​puʻupaʻa, i ka hoʻololi ʻana i nā pale pale, i nā hōʻailona inflammatory a i kekahi mau maʻi maʻi."

ʻO nā kūlana no ke kuhikuhi ʻana i kahi EPS ua kuhikuhi ʻia e ka Haute Autorité de Santé (HAS) i Ianuali 2017. ʻO ke kumu nui i hana ʻia ai kahi EPS ʻo ka ʻimi ʻana i kahi immunoglobulin monoclonal (monoclonal gammopathy, a dysglobulinemia). E neʻe kēia i ka hapa nui o ka manawa ma kahi o ka gamma globulins a i kekahi manawa ma kahi o beta-globulins a i ʻole alpha2-globulins.

I ka manawa hea e hoʻokō ai i kahi PSE?

Pono ʻoe e hana i kahi EPS i mua o:

• He pae kiʻekiʻe o ka pōʻai protein;
• ʻO ka hoʻonui ʻole ʻia o ka sedimentation rate (VS);
• ʻO nā maʻi i hoʻopaʻa ʻia, ʻo ia hoʻi ka maʻi bacteria (e ʻimi i kahi hemahema o ka immune no ka hypogammaglobulinemia);
• Nā hōʻike kino a i ʻole ke ola kino (hypercalcemia, no ka laʻana) e hōʻike ana i ka loaʻa ʻana o ka myeloma a i ʻole ka maʻi koko;
• ʻO kahi kānalua o ka maʻi inflammatory;
• ʻO ka cirrhosis paha;
• ʻO kēlā me kēia ʻimi ʻana i ka osteoporosis.

Ma muli o ka protein, pono nā helu kuhikuhi ma waena o:

• Albumin: 55 a me 65% a i ʻole 36 a me 50 g / L.
• Alpha1 - globulins: 1 a me 4% ie 1 a me 5 g / L
• .Alpha 2 - globulins: 6 a me 10% a i ʻole 4 a me 8 g / l
• .Beta – globulins: 8 a me 14% a i ʻole 5 a me 12 g / L.
• Gamma - globulins: 12 a me 20% a i ʻole 8 a me 16 g / L.
  

E ʻike ʻo Electrophoresis i nā pūʻulu o nā protein i hoʻonui a hoʻemi ʻia i ka serum. "E hoʻokumu ʻia kēlā me kēia protein koko i nā kaula o nā laula like ʻole a me ka ikaika ma muli o ko lākou nui. Hiki ke unuhi ʻia kēlā me kēia ʻano "profile" e ke kauka ". Hiki iā ia, inā pono, ke kuhikuhi i nā hoʻokolohua hou.

Nā anomali i ʻike ʻia e ka EPS

Ma waena o nā anomalies i ʻike ʻia:

• ʻO ka emi ʻana o ke kiʻekiʻe o ka albumin (hypoalbuminemia), hiki ke hana ʻia e ka ʻai ʻole, ka hemahema o ka ate, ka maʻi maʻi mau, ka myeloma a i ʻole ka nui o ka wai (hemodilution).
• ʻO ka Hyper-alpha2-globulinemia a me ka emi ʻana o ka albumin e like me kahi kūlana inflammatory. ʻO ka hui ʻana o nā hakina beta a me ka gamma e hōʻike ana i ka cirrhosis.
• ʻIke ʻia ka emi ʻana o ka gamma globulins (hypogammaglobulinemia) i ka hihia o ka dysfunction o ka ʻōnaehana pale. Ma ka ʻaoʻao ʻē aʻe, piʻi ka helu (hypergammaglobulinemia) i kahi kūlana o ka myeloma, monoclonal gammopathies a me nā maʻi autoimmune (lupus, rheumatoid arthritis).
• ʻO ka hoʻonui ʻana i nā beta globulins hiki ke manaʻo i ka hele ʻana o ka hemahema hao, hypothyroidism a i ʻole keakea biliary.

Wahi a ka HAS, ʻōlelo ʻia e hoʻouna i ka mea maʻi no ka ʻōlelo aʻo hou:

• Inā hōʻike ka hōʻike ʻana o ka maʻi i ka hematologic malignancy (ʻeha iwi, deterioration o ke kūlana maʻamau, lymphadenopathy, tumor syndrome);
• inā loaʻa kahi maʻi kūlohelohe (anemia, hypercalcemia, renal failure) a i ʻole ke kiʻi ʻana (nā iwi iwi) e hōʻike ana i ka pōʻino o ke kino;
• i ka loaʻa ʻole o ia mau hōʻailona, ​​​​ʻo ka mea maʻi nona ka liʻiliʻi o hoʻokahi o nā hoʻokolokolo lālani mua he abnormal, a i ʻole nona ka serum monoclonal immunoglobulin ʻo IgG? 15 g / L, IgA a i ʻole IgM? 10 g / L;
• inā ʻo ka mea maʻi ma lalo o 60 mau makahiki.

ʻO ka mālama ʻana i kahi anomaly o electrophoresis ʻo ia ka pathology e hōʻike ai.

"No ka laʻana, inā loaʻa ka hyperprotidemia ma muli o ka dehydration, ʻo ka mālama ʻana i ka wai hou. Inā piʻi ka alpha globulins ma muli o kahi maʻi inflammatory, ʻo ka mālama ʻana i ke kumu o ka mumū. I nā hihia āpau, ʻo ke kauka ka mea, e hoʻohana ana i kēia hoʻokolokolo a me nā hoʻokolohua hou aʻe (hoʻāʻo koko, hōʻike radiological, a me nā mea ʻē aʻe), e hana i ka maʻi maʻi i ka wā kūkākūkā a kuhikuhi i ka lāʻau lapaʻau i kūpono i ka pathology. loaʻa ”.