A hiki i kēia lā, ʻaʻohe lāʻau lapaʻau no ka maʻi o Alzheimer. Eia naʻe, he nui nā lāʻauʻona ke ulu nei a lawe mai i ka manaolana. ʻO ka nā ala lapaʻau, aia i kēia manawa i ka pae noiʻi, manaʻo e hoʻoponopono i ke kaʻina hana pathological o ka maʻi me ka manaʻolana e ho'ōla a hoʻopau paha. Eia kekahi, aia nā lāʻau e hōʻemi i ka nā hōʻailona a e hoʻomaikaʻi ai i ka hana cognitive i kekahi ʻano.

ʻIke ʻia ka maikaʻi o nā lāʻau lapaʻau e ke kauka ma hope o 3 a 6 mau mahina. Inā pono, hoʻololi ʻia nā lāʻau lapaʻau. I kēia manawa, he haʻahaʻa nā pōmaikaʻi o nā lāʻau lapaʻau a ʻaʻole pale nā ​​lāʻau i ka maʻi mai ka holomua ʻana.³⁰.

Manaʻo ka Foundation for Medical Research i ka makahiki 2016 ma kahi o 900 mau kānaka i loaʻa i ka maʻi o Alzheimer ma Farani. (ʻike i ka infographic)

nā lāʻauʻona

ka nā lāʻauʻona loaʻa ma ka ʻōlelo kuhikuhi. ʻAʻole hiki iā mākou ke ʻike a priori i kūpono loa i ka mea maʻi. I kekahi manawa he mau mahina e loaa ai ka kūpono kūpono. Wahi a nā haʻawina, ma hope o 1 makahiki o ka lāʻau lapaʻau, ʻike ka 40% o ka poʻe i ka hoʻomaikaʻi ʻana o ko lākou kūlana, 40% he kūlana paʻa a he 20% ʻaʻohe hopena.

Nā mea kūpale Cholinesterase

Hoʻohana nui ʻia lākou e mālama ʻoluʻolu a haʻahaʻa paha. Kōkua kēia ʻohana lāʻau e hoʻonui i ka ka hoʻonui i ka acetylcholine ma kekahi mau wahi o ka lolo (ma ka hoemi ana i kona luku ana). ʻAe ʻo Acetylcholine i ka hoʻouna ʻana i nā neʻe nerve ma waena o nā neurons. Ua ʻike ʻia ʻo ka poʻe me ka maʻi Alzheimer he haʻahaʻa haʻahaʻa o ka acetylcholine i loko o ka lolo no ka mea ʻo ka luku ʻana i ko lākou mau aʻalolo e hōʻemi ana i ka hana ʻana o kēia neurotransmitter.

Ma ka mākeke Kanada, aia i kēia manawa 3 inhibitors o cholinestérase (ka enzyme e hoʻopau i ka acetylcholine):

• Le donepezil a i ʻole E2020 (Aricept®). Lawe ʻia ma ke ʻano o nā papa. Hoʻopau ia i nā hōʻailona maʻalahi, haʻahaʻa a holomua o ka maʻi;
• La rivastigmine (Exelon®). Mai Feberuari 2008, ua hāʻawi ʻia ma ke ʻano o ka ʻili ʻili: ua komo mālie ka lāʻau lapaʻau e ke kino ma mua o 24 mau hola. He kūpono ʻo Rivastigmine no nā maʻi i loaʻa nā hōʻailona haʻahaʻa a haʻahaʻa paha;
• Le galantamine hydrobromide (Reminyl®). Kūʻai ʻia ʻo ia ma ke ʻano he papa i lawe ʻia i hoʻokahi lā no nā hōʻailona haʻahaʻa a haʻahaʻa paha.

Ua nalowale kēia mau lāʻau lapaʻau i ka wā lōʻihi, no ka mea, ʻoi aku ka liʻiliʻi o ka acetylcholine i nā neurons. Hiki iā lākou ke hana i nā hopena ʻaoʻao, e like me ka nausea a me ka luaʻi ʻana, nalowale ka ʻai a me ka ʻeha o ka ʻōpū. I kēia hihia, he mea nui e ʻike hou i kāu kauka, nāna e hoʻoponopono i ke ʻano e like me ka mea e pono ai.

Ma ʻAmelika Hui Pū ʻIa a me Palani, hoʻohana ʻia ka tacrine (Cognex®) ma ke ʻano he mea paʻa cholinestérase. Eia naʻe, hiki iā ia ke hana i nā hopena koʻikoʻi a ʻaʻole ʻae ʻia ma Kanada.

ʻO ka mea hoʻokūkū receptor NMDA

Mai ka makahiki 2004, ua hāʻawi ʻia ka memantine hydrochloride (Ebixa®) e hoʻomaha hōʻailona haʻahaʻa a koʻikoʻi paha o ka mai. Hana kēia mole ma ka hoʻopaʻa ʻana i nā mea hoʻokipa NMDA (N-methyl-D-aspartate) i loaʻa ma nā neurons i ka lolo. No laila, lawe ia i kahi o ka glutamate, i ka wā e loaʻa ai i nā mea nui i loko o ke kaiapuni o nā neurons, e kōkua i ka maʻi. ʻAʻohe mea hōʻike, akā naʻe, ke hoʻolohi nei kēia lāʻau i ka degeneration o nā neurons.

Ke hoʻomau nei i ka noiʻi

Ke hoʻoikaika nui ʻia nei i ka ʻimi ʻana i nā lāʻau lapaʻau hou. ʻO nā pahuhopu nui:

• E hoʻopau i nā plaque protein beta-amyloid, mahalo i ka hoʻokomo ʻia ʻana o nā antibodies hiki ke hoʻopau iā lākou. ʻO kēia mau pāpaʻi, ʻo ia kekahi o nā maʻi lolo koʻikoʻi i ka maʻi. Ua hoʻomohala ʻia kēlā ʻano antibody (ʻo ka inoa o ka molekala ʻo bapineuzumab) a aia ma lalo o ka loiloi loiloi i nā poʻe me ka maʻi. Kapa ʻia kēia ʻano he "vaccine therapeutic". ʻO kekahi hoʻonā i hoʻāʻo ʻia ʻo ia ka hoʻāla ʻana i kekahi mau sela lolo (microglia) i mea e hoʻopau ai lākou i nā plaque i nīnau ʻia;
• Hoʻololi i nā neurons. Ke manaʻolana nui nei ka poʻe ʻepekema i ka hoʻololi ʻana, me ke kōkua o kahi transplant, nā neurons i luku ʻia e ka maʻi. I kēia mau lā, hiki i nā mea noiʻi ke hana i nā pūnaewele e like me nā neurons mai nā cell stem i loaʻa mai ka ʻili kanaka. Akā naʻe, ʻaʻole i hoʻomohala ʻia ke ʻano. ʻAʻole hiki iā ia ke hana i nā neurons i loaʻa nā waiwai āpau o nā neurons "kūlohelohe".

ʻO ka hoʻoikaika kino

Paipai ikaika nā kauka i ka poʻe me ka maʻi Alzheimer e laweme ka. Hoʻonui ia i ka ikaika, ka hoʻomanawanui, ke olakino cardiovascular, ka hiamoe, ke kahe koko a me ke ʻano, a hoʻonui i ka dynamism a me nā pae ikehu. Eia kekahi, he hopena maikaʻi loa ka hoʻoikaika kino kino i nā poʻe me kēia maʻi:

• kōkua ia i ka mālama ʻana i nā mākau kaʻa;
• hāʻawi ia i ka manaʻo o ke ʻano a me ke kumu;
• he hopena hoʻomaha;
• mālama ia i ke kiʻekiʻe o ka ikehu, ka maʻalahi a me ke kaulike;
• hoemi ia i ka pilikia o ka poino nui i ka haule ana.

Hiki i ka poʻe mālama i ka poʻe maʻi ke pepehi i ʻelua manu me ka pōhaku hoʻokahi ma ka hoʻoikaika ʻana i ka manawa like me ko lākou mau maʻi.¹⁷.

Kākoʻo kaiāulu

Manaʻo ʻia he ʻāpana o ka mālama ʻana, ka kōkua kaiaulu lawe ʻia i ka maʻi he mea koʻikoʻi. Paipai nā kauka i nā hoʻolālā like ʻole ohana a nā mea mālama maʻi.

• E hele mau i nā maʻi e hāʻawi i ke kākoʻo iā lākou, e like me ko lākou makemake;
• Hāʻawi iā lākou i nā mea hoʻomanaʻo;
• E hana i kahi hale noho paʻa a mālie i ka hale;
• E hoʻokumu i kahi hoʻomana moe;
• E hōʻoia i ka pilikia iki o ko lākou kaiapuni;
• E mālama pono iā lākou he kāleka (a i ʻole kūpeʻe lima) i loko o kā lākou ʻeke me ka hōʻike ʻana i ko lākou kūlana olakino, a me nā helu kelepona inā nalowale lākou.

Hāʻawi pū nā hui i ke kākoʻo ma nā ʻano like ʻole. E ʻike i ka ʻāpana Paena o ka hoihoi.