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Ua ʻike ʻia kahi pūhui kemika i loaʻa nā waiwai analgesic ikaika ma ke Kulanui o Warsaw. Inā kūleʻa nā ʻanuʻu e hiki mai ana i nā hoʻokolohua lapaʻau, e hoʻokuʻu ʻia kahi lāʻau lapaʻau i ʻoi aku ka maikaʻi o 5000 mau manawa ma mua o nā lāʻau ʻeha ikaika loa i loaʻa i kēia manawa i ka mākeke.
Ma ke kiʻi: he hui o nā ʻepekema mai ke Kulanui o Warsaw - Beata Wileńska, Rafał Wieczorek, Bartłomiej Fedorczyk
Hiki ke hoʻohana ʻia kēia lāʻau no ka hoʻomaha ʻana i ka ʻeha neuropathic, i nā kūlana traumatic koʻikoʻi a i ka lāʻau palliative, ʻo ia hoʻi i nā kūlana i hāʻule mua nā lāʻau ikaika loa mai ka ʻohana opioid.
ʻO kahi mea hou mai ka ʻohana peptidomimetic me nā waiwai analgesic ikaika i hoʻomohala ʻia e kahi hui i alakaʻi ʻia e Prof. Aleksandra Misicka-Kęsik ma ka Faculty of Chemistry, University of Warsaw, i ka hui pū ʻana me prof. ʻO Barbara Przewłocka mai ka Institute of Pharmacology o ka Polish Academy of Sciences. ʻO kahi lāʻau lapaʻau kūpono ke kumuhana o kahi noi no ka pale patent ma Polani a ma nā ʻāina i koho ʻia o ka honua. Ma ka like, ma hope o ka ho'āʻo holoholona maikaʻi loa, ke hoʻomaka nei ka hana holomua e hoʻomaka i ka pae mua o nā hoʻokolohua lapaʻau.
E hoʻomaka ana nā hoʻokolohua lapaʻau a me nā noiʻi hou aku
Ua loaʻa mai ka papahana i ke kālā nui mai ka Intelligent Development Operational Program Measure 1.1 (mai ka National Center for Research and Development, ma lalo o ka mea i kapa ʻia ʻo ka wikiwiki) i ka nui o PLN 12,6 miliona. ʻO ia kekahi o nā papahana ʻepekema a hoʻokō kiʻekiʻe loa i hāʻawi ʻia i kēia papahana, e hōʻike ana hoʻi i ke ʻano hoʻohiki a me ka hiki ke ʻike. ʻO nā kālā i loaʻa e hiki ke hoʻomaka i ka pae mua o nā hoʻokolohua lapaʻau a no ka noiʻi hou ʻana i ka lāʻau lapaʻau hou. - ʻO kā mākou hoʻolālā e noiʻi i ka wikiwiki o ka hoʻolaha ʻana o ka lāʻau lapaʻau i ke kino o ke kanaka, he aha nā ala maikaʻi loa o kāna hoʻoponopono ʻana, he aha nā hopena ʻaoʻao e loaʻa ai a, ʻoiaʻiʻo, inā paha e hōʻike ana i nā mea ʻawaʻawa - wehewehe ʻo Dr. Rafał Wieczorek mai. ka hui noiʻi i hoʻomohala i ka pūhui ma ka Faculty of Chemistry, University of Warsaw.
ʻO ke ʻano o ka lāʻau lapaʻau - no hea mai kona hopena?
No ka ʻohana peptidomimetics ka mole i ʻike ʻia, ʻo ia hoʻi nā pūhui kemika e hoʻohālike i nā peptides i loaʻa i loko o nā cell ola, e laʻa me nā hormones. Nui nā peptides i loko o ke kino o ke kanaka, a ʻo kā lākou haʻahaʻa haʻahaʻa e hoʻoponopono mau ʻia e nā ala kūlohelohe. ʻOiai e hana ana i nā peptidomimetics hou, hoʻāʻo nā chemists e hana i nā molekala e hoʻohālikelike i nā hormones, e hoʻohaʻahaʻa ʻia e nā enzyme cellular, mahalo i hiki ke hoʻokō i nā ʻano lapaʻau like ʻole e like me ka hoʻoponopono ʻana i ke kaulike hormonal.
ʻO ka hui i ʻike ʻia e kahi hui ʻepekema ʻelua mau hana. - Laki loa mākou no ka mea ua hana mākou i kahi pilina bifunctional. Hoʻokahi ʻāpana o kā mākou mole e hana i nā mea hoʻokipa opioid, ʻo ia hoʻi ka hoʻopau ʻana i nā hopena ʻeha, aʻo ka ʻāpana ʻē aʻe e hana i ka ʻehā melanocortic receptor, nona ke kuleana no ka hoʻouna ʻana i ka hōʻailona e hoʻomaka ai i ka ʻeha. I nā huaʻōlelo ʻē aʻe, ʻo ka hoʻokele ʻana i hoʻokahi hui e hoʻouna i ke kino i ka manawa like i kahi hōʻailona e kāohi a hoʻomaha i ka ʻeha i loaʻa mua, a ʻo ka hōʻailona lua e kinai i ke kumu o kona hoʻokomo ʻana. He mea maikaʻi loa kēia ma mua o nā lāʻau hōʻeha i ʻike mua ʻia, no ka mea, hana lākou a pau ma ke ʻano hoʻokahi a i ʻole, akā ʻaʻole hoʻohana kekahi o lākou i ka manawa like - hoʻohui ʻo Rafał Wieczorek.
Ua hōʻike ʻia nā haʻawina holoholona e hōʻike ana ka pūhui i ʻike ʻia ma kahi o 5000 mau manawa ʻoi aku ka hopena analgesic ma mua o nā opioids i loaʻa ma ka mākeke. ʻO kēia ʻokoʻa nui paha ma muli o ka synergy o ʻelua mau ʻano hana o ka pūhui i ʻike ʻia.
- Loaʻa i ka ʻike ka mana nui no ke kālepa. ʻO ka hoʻokō kūleʻa ʻana o nā pae hope o nā hoʻokolohua lapaʻau e ʻae ʻia no ka hana ʻana i kahi lāʻau lapaʻau maikaʻi loa i loaʻa ʻole ma ka mākeke a hiki i kēia manawa. I ka hoʻomaʻamaʻa ʻana, he mea hoʻopakele ia no nā poʻe he nui e hakakā nei me ka ʻeha mau, ʻaʻohe mea hoʻopakele kūpono i kēia manawa. ʻO kahi wānana maikaʻi loa e loaʻa i nā ʻepekema ke kālā nui no ka noiʻi hou ʻana, e hiki ai iā lākou ke komo i nā pae koʻikoʻi o nā hoʻokolohua lapaʻau. Wahi a ka helu ʻana, ma waho aʻe o ke kālā mai ka National Center for Research and Development, ma kahi o PLN 5 miliona e pono ai e pani i ka waihona kālā no ka pae mua o nā hoʻokolohua holomua. No kēia kumu, ke hana nei mākou i nā kamaʻilio like ʻana me nā ʻoihana hoihoi. Ke hilinaʻi nei au e ʻike koke ʻia kahi mea hoʻopukapuka - wahi a Kauka Robert Dwiliński, Luna Hoʻokele o ka University Center for Technology Transfer ma ke Kulanui o Warsaw.
He mea hou mai ke Kulanui o Warsaw
I kekahi mau mahina i hala aku nei, ua hoʻokumu ʻo Kauka Rafał Wieczorek me kāna mau hoa hana i kahi hui spin-off o ke kulanui - Matariki Bioscience. ʻO kekahi o kāna mau pahuhopu ʻo ia ka lawe ʻana i kahi painkiller kipi i ka mākeke. Eia hou, ua ʻike ka hui o Matariki i nā pūhui i loko o kāna kōpili i hiki ke hoʻohana ʻia i ka hoʻolālā ʻana i nā lāʻau like ʻole i hoʻohana ʻia i nā lāʻau lapaʻau. Ma ka manawa like, e like me ka manaʻo o Dr. Wieczorek, ua mākaukau ka hui e hāʻawi i nā lawelawe i ke kauoha o nā mea hoʻopukapuka hoʻokahi e makemake ana e ʻimi i nā molekala me nā waiwai kemika a i ʻole biophysical.
Ma kahi o morphine
I kēia manawa, hoʻohana ʻia nā lāʻau lapaʻau mai ka ʻohana opioid, e like me, no ka laʻana, morphine, i mea hoʻomaha i ka ʻeha neuropathic. ʻO nā hemahema o kēia mau lāʻau lapaʻau, he mau mea hoʻohui a me nā hopena koʻikoʻi. Eia kekahi, me ka hoʻohana ʻana o ka opioids i nā mea maʻi, ʻo ka mea i kapa ʻia ʻo ka hopena o ke kaupaku - hoʻomaha ʻeha e pono ai ka hoʻokō ʻana i ka nui o ka nui o ka lāʻau lapaʻau, a mai kahi manawa e hoʻonui ai, pau ka hopena o ka lāʻau. ʻO ka hoʻokomo ʻana i kahi lāʻau lapaʻau hou e pili ana i ka peptidomimetic e hāʻawi i ka manaʻolana no ka hoʻopau ʻana i ka ʻeha lōʻihi a lōʻihi, no ka mea, ke hoʻohālikelike ʻia me ka morphine, koi ʻia kahi ʻano o ka lāʻau i hoʻemi ʻia he mau kaukani no ka loaʻa ʻana o ka hopena, a ʻo ia hoʻi, ua hōʻike ʻia nā hoʻāʻo holoholona he a ʻO ka nui o ka nui e hoʻopau loa i ka ʻeha, ʻoiai inā i loaʻa mai ia mai nā aʻalolo i hōʻino ʻia a hoʻonāukiuki paha.