ʻO ka acidosis ka hopena o nā maʻi metabolic like ʻole a me nā maʻi i hoʻopuka ʻia ai ka waikawa nui. He pilikia nui ia i kekahi manawa. Hoʻokumu ʻia kāna hoʻokele ma ka mālama ʻana i ke kumu. 

ʻO ka hele ʻana o ka metabolic acidosis i loko o ke kino e pili ana i ka hoʻonui ʻana i ka hana a i ʻole ka ʻai ʻana i nā waikawa a / a i ʻole ka emi ʻana o ka excretion o nā waikawa. ʻO ia hoʻi i kekahi manawa ka hopena o ka nalo ʻana o ka digestive tract a i ʻole nā ​​puʻupaʻa o ka bicarbonates (HCO3-) ka mea maʻamau e pale i ka nui o ka nui o nā waikawa i loko o ke koko a komo i kāna koena acid-base.

ʻO ka maʻamau, ʻo ka plasma (kahi hapa o ke koko ʻaʻohe ʻulaʻula ʻulaʻula, keʻokeʻo keʻokeʻo a me nā platelets) he wai kūʻokoʻa uila, ʻo ia hoʻi, aia i loko o ka nui o nā kumu ionic maikaʻi ʻole e like me ka maikaʻi (HCOE-, H +, Na +, K +, CL-…). ʻO ia ka wā i ʻoi aku ka nui o nā kumu kūpono i ka nui o ka metabolic acidosis.

Nui nā kumu o ka metabolic acidosis. ʻAʻole ʻo ka metabolic acidosis kahi maʻi iā ia iho, akā ʻo ka hōʻike ʻana o ke kino o ke koko ma waena o ka acidity a me ka bicarbonates. ʻO kēia ʻano like ʻole ka hopena o kekahi mau pilikia.

Loaʻa ka nui o ka lactic acid ma o ka hōʻiliʻili ʻana i loko o ke koko

ʻO kēia organik metabolic acidosis ma muli o: 

• kahi kūlana o ka haʻalulu physiological; 
• ʻaʻole hana ke ake i kāna mau hana e hoʻomaʻemaʻe i ke koko;
• he maʻi koko e like me ka maʻi maʻi leukemia a i ʻole lymphoma (ke maʻi maʻi maʻi lymph nodes);
• ka maʻi maʻi maʻi maʻi (ʻaʻole e wehe hou nā puʻupaʻa i ka waika nui mai ke koko); 
• meaʻai make (methanol, salicylates, ethylene glycol, etc.);
• ketoacidosis (ka maʻi maʻi i ka wā e pau ai ka insulin).

Loaʻa ka nui o ka lactic acid i loko o ke koko ma o ka hōʻemi ʻana i kona hoʻopau ʻana

Loaʻa kēia mineral metabolic acidosis mai:

• hōʻeha kīnā ʻole;
• ka nui o ka NaCl chloride infusion (paakai);
• ka nalowale o ka bicarbonate mai nā puʻupaʻa;
• ka nalowale o ka bicarbonate mai ka ʻāpana digestive (diarrhea);
• lawa ole adrenal.

Hiki i ka Metabolic acidosis ke loaʻa i ka hāʻule ʻole ʻana o ka hanu i hiki ʻole i ke kino ke hoʻopau hou i ke kalapona ma o ka māmā, kahi e hoʻokahe ai i ka plasma koko. A laila kapa ʻia ka acidosis "respiratory".

Ke hoʻopilikia ʻia ke koena o ka acid-base o ke kino me ka nānā ʻole i ke kumu, hiki ke hōʻike ʻia nā hōʻailona like ʻole. Inā he haʻahaʻa kēia ʻano kaulike ʻole, ʻaʻohe hōʻailona koe wale nō ke kumu kumu (ka maʻi ʻeha, ka ʻehaʻeha i pili i ka maʻi diabetes ʻole, etc.). Akā, ua hoʻokūpaʻa ʻia ka imbalance (pH <7,10), hiki ke loaʻa nā hōʻailona penei:

• nausea;
• ka luaʻi;
• manaʻo maikaʻi ʻole;
• hoʻonui i ka hanu hanu (polypnea i ka hoʻāʻo e hoʻopau i ka nui o ka metabolic acidity);
• ke koko haʻahaʻa (hypotension) a i ʻole ka haʻalulu puʻuwai me ka arrhythmias puʻuwai a me ka coma.

Ke loaʻa kēia acidosis ma ke ʻano maʻamau (ka hanu hanu maʻamau…), hiki ke hoʻolilo i ka manawa waena i ka nalowale o ka calcium mai nā iwi (osteoporosis, rickets).

Ma waho aʻe o ka ʻimi ʻana i kahi kumu kumu ma o nā hoʻokolohua hoʻohui, kahi hoʻāʻo koko ma ke kiʻekiʻe o nā aʻa e ana i nā kinoea koko a me nā electrolytes serum e hiki ai ke hōʻike i nā hopena biological o metabolic acidosis.

ʻO nā kumu kumu o ka metabolic acidosis e kānalua ʻia e ka mōʻaukala olakino (diabetes, respiratory, renal or hepatic insufficiency ...) akā naʻe ma o kahi loiloi olaola e ʻimi ana i nā pae kō koko, hepatic a me ka hana renal, sodium a me ka chlorine koko, a i ʻole kahi huahana ʻona i loko. ke koko (methanol, salicylate, ethylene glycol).

ʻO ka mālama ʻana i ka acidosis metabolic ʻo ia ka mea mua o ke kumu (ka maʻi diabetes ʻole, ka maʻi maʻi, hepatic, renal or respiratory failure, etc.). Akā i ka pilikia i ka wā e koʻikoʻi ai ka metabolic acidosis, pono i kekahi manawa e hoʻokō i kahi infusion o ka sodium bicarbonate e hoʻemi i ka acidity o ka plasma koko.

I ka hopena o ka hōʻino ʻana o ka renal a i ʻole ka make ʻana, hemodialysis (ka holoi ʻana i nā toxins mai ke koko) e hoʻomaʻemaʻe i ke koko a hoʻololi i ka hana o nā puʻupaʻa.

ʻO ka mea hope loa, i ke alo o ka acidosis maʻi maʻamau, ʻōlelo ʻia kahi meaʻai e hoʻihoʻi i ke koena acid-base o ke koko me nā ʻōlelo aʻoaʻo:

• koho i ka meaʻai alkaline nui (lemon cure, ginger tea, hua paukena, etc.);
• loaʻa ka oxygen ma ka hoʻomaʻamaʻa ʻana i kahi hana haʻuki maʻamau i ka lewa ākea;
• lawe i nā meaʻai e hoʻoikaika i ka alkaliization o ke koko.