Kapa pū ʻia ʻo fetuin, kaalpha-fetoprotein he kumuʻiʻo hana maoli ʻia e ʻeke yolk a ate du pēpē i ka hoʻomohala. ʻIke ʻia i ke koko fetal a me nā mākua (i ka wā hāpai). I nā keiki hānau hou, hoʻemi kona helu i kekahi mau pule ma hope o ka hānau ʻana.

I nā mākua, hiki i ka alpha-fetoprotein ke hele hou i ka wā o kekahi mau maʻi, ka hapa nui o ka manawa hepatic a me ka tumo.

Hiki ke kuhikuhi ʻia ka aniani Alpha-fetoprotein no ka wahine i ka wā hāpai a i ʻole no nā mākua ma waho o ka hāpai keiki.

i ka hāpai keiki, alpha-fetoprotein analysis e hoʻohana ʻia no ka prenatal diagnose o nā ʻano ʻokoʻa like ʻole a hana ʻia i ka lua o ka trimester. ʻOi loa ka hōʻoia ma waena o nā pule he 16 a me ka 18. ʻIke ʻia ka alpha-fetoprotein me ke ʻano o ka homone chorionic gonadotropic (HCG), estriol a me ka inhibin A, nā homone placental. ʻO ka pahuhopu e ʻike pono i kahi malformation o ka neural tube (ka mea e lilo i ʻōnaehana hopohopo) o ke fetus, e like me Spina bifida, akā me nā mea chromosomal abnormalities, e like me ka makaʻu o trisomy 21 (a i ʻole Down's syndrome).

I nā mākua (ma waho o ka hāpai ʻana), hiki ke hana ʻia ka alpha-fetoprotein analysis e hōʻoia i nā pilikia o ke ake a i ʻole e ʻike i kekahi mau maʻi maʻi maʻi.

ʻO ke kālailai ʻana o ka alpha-fetoprotein a hoʻokahe koko i ka pae o ka aa a ʻaʻole koi i kekahi hoʻomākaukau kikoʻī. Hoʻonoho ke kauka i kahi hoʻokūkū ma ka lima mua o ka mea maʻi, ma kahi o 10 cm ma luna o ka pūnaewele kahi o ka venipuncture e hana ai, ma ka maʻamau o ka kuʻekuʻe lima.

I nā wahine hāpai, ʻo kahi ʻāpana o ka alpha-fetoprotein i hana ʻia e ka pēpē e hele i loko o ke koko makuahine, a no laila ʻaʻole koi ʻia kahi amniotic a i ʻole fetal sampling. Lawe ʻia ka laʻana koko i kahi ala "kilakila".

I nā mākua, nā kāne a me nā wahine ma waho o ka wā hāpai, ʻo ka nui maʻamau o ka alpha-fetoprotein ma lalo o 10 ng / ml o ke koko.

Hōʻike ka hoʻonui ʻana i ka pae o ka alpha-fetoprotein i ke koko:

• maʻi ate, e like me maʻiʻeha, no kahi an maʻi ʻaʻai ate, ka hepatitis ʻona ai ole ia, hepatitis viral

• un Ka maʻi 'aʻai testicle, ovaries, ʻōpū, pancreas a i ʻole nā ​​aʻa o ka bile.

I nā wahine hāpai, i ka lua o ka trimester, aia ka pae alpha-fetoprotein ma waena o 10 a 200 ng / ml. Hiki i nā pae alpha-fetoprotein kiʻekiʻe ke kumu:

• kahi kīnā neural tube i ka fetus ulu: Spina bifida, anencephaly

• kahi malformation neurological

• hydroencephaly

• kahi malformation o ka esophagus a i ʻole nā ​​puʻupaʻa

ʻO ka mea ʻē aʻe, hiki i kahi pae haʻahaʻa ke hōʻailona o kahi kino chromosomal e like me Down Syndrome (trisomy 21).

E akahele, akā, ʻokoʻa ka pae alpha-fetoprotein i ka wā hāpai. No laila he mea nui e ʻike kikoʻī i ke kahua o ka hāpai keiki kahi a ka wahine i ka wā o ka hoʻāʻo. ʻO nā hopena alpha-fetoprotein kūpono ʻole ma muli o ka hāpai ʻana a i ʻole ka make o fetal.

No laila pono nā ho'āʻo hou i ka hanana o ka alpha-fetoprotein pae ʻole, e like me kahi ultrasound a i ʻole amniocentesis (hemo o ka wai amniotic e hoʻopuni ana i ka fetus).