ʻO ka follicle stimulating hormone, a i ʻole FSH, he hormone nui o ka momona i nā kāne a me nā wahine. ʻO ia ke kumu i ka wā o ka nānā ʻana i ka hānau ʻana, nānā ʻia kona helu.

I nā wahine

Loaʻa ka HSF i ka māhele mua o ka pōʻai ovarian, i kapa ʻia ʻo ka follicular phase. I loko o kēia māhele, hoʻomaka i ka lā mua o ka menstruation a hoʻopau i ka manawa o ka ovulation, hūnā ka hypothalamus i kahi neurohormone, GnRH (gonadotropin hoʻokuʻu hormone). E hiki mai ana ka hopena o ke kaulahao:

• Hoʻouluʻo GnRH i ka pituitary gland, i ka paneʻana i ka FSH;
• ma lalo o ka mana o FSH, ma kahi o iwakālua ovarian follicles e hoʻomaka e ulu;
• ʻO kēia mau follicles oʻo e hoʻohuli i ka estrogen, ke kuleana no ka mānoanoa o ka ʻōpū o ka ʻōpū i mea e hoʻomākaukau ai i ka ʻōpū no ka loaʻa ʻana o kahi hua manu fertilized;
• i loko o ka cohort, hoʻokahi follicle, i kapa ʻia ʻo ka dominant follicle, loaʻa ka ovulation. E hoʻopau ʻia nā mea ʻē aʻe;
• ke koho ʻia ka follicle preovulatory nui, piʻi nui ka huna ʻana o ka estrogen. ʻO kēia hoʻonui ke kumu o ka piʻi ʻana o ka LH (luteinizing hormone) e hoʻoulu ai i ka ovulation: haki ka follicle makua a hoʻokuʻu i kahi oocyte.

Ma ke kikowaena o kēia hopena kaulahao, no laila ʻo FSH kahi hormone nui no ka momona.

I ke kanaka

Hoʻopili ka FSH i ka spermatogenesis a me ka huna ʻana o ka testosterone. Hoʻoulu ia i nā pūnaewele Sertoli nāna e hoʻopuka i ka sperm i loko o nā hōʻike.

I nā wahine, Hiki ke kuhikuhi ʻia kahi ʻano o ka FSH i nā kūlana like ʻole:

• i ka wā o ka amenorrhea mua a / a i ʻole ka wā ʻōpio: ua hana ʻia kahi ʻano hui o FSH a me LH i mea e hoʻokaʻawale ai ma waena o ke kumu mua (kahi kumu ovarian) a i ʻole ka lua (ke kumu kiʻekiʻe: hypothalamus a i ʻole pituitary) hypogonadism;
• i ka hihia o ka lua amenorrhea;
• i ka wā o ka pilikia fertility, hana ʻia kahi loiloi hormonal me ke ʻano o nā hormones sex like ʻole: follicle stimulating hormone (FSH), estradiol, luteinizing hormone (LH), antimulleric hormone (AMH) a i kekahi mau hihia prolactin, TSH (thyroid). ), testosterone. ʻO ka hoʻāʻo ʻana no FSH kōkua i ka loiloi ʻana i ka mālama ovarian a me ka maikaʻi o ka ovulation. Hiki iā ia ke ʻike inā pili ka maʻi ovulation a i ʻole amenorrhea ma muli o ka ʻelemakule ovarian a i ʻole ke komo ʻana o ka pituitary gland.
• i ka menopause, ʻaʻole koi ʻia ka hoʻoholo ʻana o FSH e hōʻoia i ka hoʻomaka ʻana o ka pre-menopause a me ka menopause (HAS, 2005) (1).

I ke kanaka

Hiki ke hana ʻia kahi hōʻike FSH ma ke ʻano o ka loiloi fertility, ma ke alo o kahi spermogram abnormality (azoospermia a i ʻole oligospermia koʻikoʻi), i mea e ʻike ai i ka hypogonadism.

Lawe ʻia nā ana Hormonal mai kahi hoʻāʻo koko, ʻaʻole ma ka ʻōpū ʻole.

• i nā wahine, lawe ʻia nā hoʻoholo o FSH, LH a me estradiol i ka lā 2nd, 3 a i ʻole 4 o ka pōʻai i loko o kahi keʻena reference.
• i loko o ke kanaka, hiki ke hana ʻia ke ʻano FSH i kēlā me kēia manawa.

I nā wahine:

• ʻo ka piʻi nui o FSH a me LH e hōʻike ana i ka hemahema o ka ovarian mua;
• ʻO ka emi nui o ka LH a me ka FSH e hōʻike pinepine ana i ka pōʻino i ka pituitary gland, ka mea mua a i ʻole ke kula kiʻekiʻe (tumor, pituitary necrosis, hypophysectomy, etc.);
• inā kiʻekiʻe ka FSH a / a i ʻole estradiol haʻahaʻa, ua manaʻo ʻia ka emi ʻana o ka mālama ovarian ("early menopause").

I ke kanaka:

• ʻO ka pae FSH kiʻekiʻe e hōʻike ana i ka pōʻino testicular a i ʻole seminiferous tubular;
• inā haʻahaʻa, manaʻo ʻia ke komo ʻana "kiʻekiʻe" (hypathalamus, pituitary). E hana ʻia kahi MRI a me kahi hoʻāʻo koko hoʻohui e nānā i ka lawa ʻole o ka pituitary.

I nā wahine:

• i ka hopena o ka hemahema o ka ovarian a i ʻole ke komo ʻana o ka pituitary gland, e hāʻawi ʻia ka lāʻau hoʻoulu ʻana i ka ovarian. ʻO kāna pahuhopu ka hana ʻana i hoʻokahi a ʻelua paha oocytes makua. Loaʻa nā protocol like ʻole, ma ke ala waha a i ʻole nā ​​injections;
• i ka wā o ka menopause premature, hiki ke hāʻawi ʻia kahi hāʻawi oocyte.

I ke kanaka:

• i ka hopena o ka hypogonatotropic hypogonadism (ka hoʻololi ʻana o ka hypotalamic-pituitary axis) me ka azoospermia koʻikoʻi a i ʻole oligospermia, e kuhikuhi ʻia ka lāʻau lapaʻau e hoʻihoʻi i ka spermatogenesis. Hiki ke hoʻohana ʻia ʻelua ʻano mole: gonadotropins me ka hana FSH a me nā gonadotropins me ka hana LH. ʻO nā protocols, ʻokoʻa e like me ka mea maʻi, hope 3 a 4 mau mahina, a ʻoi aku paha i kekahi mau kūlana.
• inā loaʻa ka hoʻololi sperm koʻikoʻi a me kekahi azoospermia (no ka mea hiki ke wehe i ka sperm mai ka epididymis a i ʻole testis), hiki ke hāʻawi ʻia ʻo IVF me ICSI. ʻO kēia ʻenehana AMP ka hoʻokomo pololei ʻana i kahi sperm i loko o ka cytoplasm o ka oocyte makua;
• Hiki ke hāʻawi ʻia ka hāʻawi sperm i nā kāne inā ʻaʻole hiki ke hoʻihoʻi ʻia ka spermatogenesis.