ʻO ka purpura fulminans kahi maʻi infectious e hōʻike ana i kahi ʻano koʻikoʻi o ka sepsis. Hoʻopili ia i ke koko a me ka necrosis kiko. Ma muli o ka ma'i maningococcal invasive a he make kona hopena ke mālama 'ole 'ia i ka manawa.

ʻO ke kuni kiʻekiʻe, ka hōʻino nui ʻana o ke kūlana maʻamau, ka luaʻi a me ka ʻeha o ka ʻōpū nā hōʻailona mua ʻole. Hoʻokahi a ʻoi aʻe paha nā kiko ʻulaʻula a me ka poni e laha koke ma ka ʻili, pinepine ma nā lālā lalo. ʻO kēia ka purpura, ka maʻi koko o ka ʻili. ʻAʻole hiki i ka ʻili ke hoʻokahe i ke koko a ʻaʻole hoʻi e nalowale ka ʻili i kahi manawa, he hōʻailona o ka "extravasation" o ke koko i loko o nā kiko. ʻO kēia ke kumu o ka Purpura Fulminans ke kumu o ka hoʻolaha ʻana i ka intravascular coagulation (DIC), ʻo ia ka hoʻokumu ʻana o nā clots liʻiliʻi e hoʻopau i ke kahe koko (he thrombosis), kuhikuhi iā ia i ka dermis a hoʻoulu i ka hemorrhage a me ka necrosis o ka ʻili ʻili. Hiki ke hoʻopili ʻia ka maʻi infectious me kahi kūlana haʻalulu a i ʻole ka haunaele o ka ʻike o ka mea i hoʻopilikia ʻia.

I ka hapanui o nā hihia, pili ka purpura fulminans i kahi maʻi bacterial invasive a koʻikoʻi. Neisseria meningitidis (meningococcus) ʻo ia ka maʻi maʻi maʻamau e pili ana, e helu ana ma kahi o 75% o nā hihia. Loaʻa ka pilikia o ka hoʻomohala ʻana i ka purpura fulminans ma 30% o nā maʻi maningococcal invasive (IIMs). (2) 1 a 2 mau hihia o IMD no 100 poʻe e noho nei i kēlā me kēia makahiki ma Palani, me kahi helu make ma kahi o 000%. (10)

ʻO nā ʻākena bacteria ʻē aʻe ke kuleana no ka hoʻomohala ʻana i nā purpura fulminans, e like me ʻO Streptococcus pneumoniae (pneumococcus) a i ʻole ʻO Haemophilus influenzae (Pfeiffer's bacillus). I kekahi manawa, ʻo ke kumu he hemahema i loko o ka protein C a i ʻole S, kahi mea e hana ai i ka coagulation, ma muli o kahi ʻano ʻano genetic hoʻoilina: kahi hoʻololi o ka gene PROS1 (3q11-q11.2) no ka protein C a me PROC gene (2q13-q14) no ka protein C. Pono e hoʻomaopopo ʻia e hiki i ka purpura fulgurans ke hopena mai kahi maʻi maʻalahi e like me ka maʻi maʻi moa, i nā hihia kakaʻikahi loa.

Hiki i ka Purpura fulminans ke hoʻopilikia i nā makahiki āpau, akā ʻoi aku ka pilikia o nā pēpē ma lalo o 15 mau makahiki a me nā ʻōpio 20 a 1 mau makahiki. (XNUMX) Pono e loaʻa i ka poʻe i pili kokoke i ka mea i loaʻa i ka haʻalulu septic i ka mālama prophylactic e pale ai i ka pilikia o ka maʻi.

Hoʻopili pololei ʻia ka wānana i ka manawa i lawe ʻia e mālama. Hōʻike maoli ʻo Purpura fulminans i kahi kūlana lapaʻau o ka wikiwiki loa e koi ai i kahi lāʻau antibiotic i ka wā hiki, me ke kali ʻole i ka hōʻoia ʻana o ka maʻi maʻi a ʻaʻole i kau ʻia i nā hopena mua o kahi moʻomeheu koko a i ʻole kahi hoʻāʻo koko. ʻO kahi purpura me kahi ma kahi o hoʻokahi kiko me ke anawaena i ʻoi aku a i ʻole like i 3 millimeter, pono e hoʻomaka koke i ka makaʻala a me ka lāʻau. Pono ka lāʻau antibiotic i kūpono no nā maʻi meningococcal a hana ʻia me ka intravenously a i ʻole, i ʻole, intramuscularly.