Ua hoʻomohala nā kānaka ʻepekema mai ka Lodz University of Technology i kahi lole hydrogel hou no ka mālama ʻana i nā ʻeha maʻi maʻi. Hāʻawi ka lole i kahi tetrapeptide i ka ʻeha e hiki ke hoʻihoʻi a hana i nā kīʻaha koko hou i loko.
Wahi a ka poʻe noiʻi, hiki i ka hoʻohana ʻana i ia ʻano lole ke hōʻemi i ka nui o nā ʻoki.
ʻO ka mālama ʻana i nā ʻeha maʻi maʻi i kēia manawa he pilikia nui loa ma Polani a ma ka honua ma mua o ka mālama ʻana i nā ʻano ʻeha ʻē aʻe. ʻO nā kumukūʻai o ia mau lāʻau lapaʻau a me nā hopena pili o nā ʻeha maʻi maʻi he nui - no kēia kumu ma Polani ma mua o 10 mau lāʻau lapaʻau e hana ʻia i kēlā me kēia makahiki. ʻoki ʻana i nā lālā. Ma muli o ke ʻano kikoʻī o kēia mau ʻeha, ʻaʻohe mea biomaterial i kūkulu ʻia i ka honua e hoʻonui nui i ka hiki ke ho'ōla.
ʻO ka hui o prof. Ua hoʻomohala ʻo Janusz Rosiak mai ka Interdepartmental Institute of Radiation Technology o ka Lodz University of Technology i kahi ʻenehana no ka hana ʻana i nā lole hydrogel i hoʻonui ʻia me kahi tetrapeptide, e hoʻoulu ai i ka angiogenesis, ʻo ia hoʻi ka hoʻihoʻi ʻana a hana i nā kīʻaha koko hou i loko o ka ʻeha. Hāʻawi ka hoʻāʻo ʻana o ke kelepona o ia mau biomaterial i nā hopena maikaʻi.
Ua hana ʻia ka ʻaʻahu ma ke kumu o kahi lole hydrogel i hoʻomohala ʻia e nā ʻepekema mai Łódź, kahi - e like me kā lākou ʻenehana - ua hana ʻia ma ka honua holoʻokoʻa no nā makahiki he 20. Loaʻa iā ia nā waiwai o kahi lole kūpono, a mahalo iā ia, loaʻa nā hopena maikaʻi loa i ka mālama ʻana i nā ʻeha kuni, bedsores a me nā ʻeha paʻakikī ke ho'ōla, e laʻa me nā ʻeha trophic.
Hoʻopili pololei ʻia ʻo Hydrogel dressing i ka ʻeha, incl. hāʻawi i ka oxygen e komo i ka ʻeha, lilo i mea pale i ka maʻi o waho, hoʻomoʻi i nā exudates, hāʻawi i kahi ʻoluʻolu, hoʻomaha i ka ʻeha, wehe i ka ʻiʻo necrotic mai ka ʻeha ke wehe ʻia mai ka ʻeha. I ka manawa like, hiki iā ia ke hoʻopaʻa i ka lāʻau lapaʻau (ma kēia ʻano ka tetrapeptide) i ka manawa paʻa mau, me ka ʻole o ka pono o ke kauka.
Me he mea lā hiki ke hoʻohana nui ʻia ka hopena a mākou i kūkulu ai i ka mālama ʻana i nā ʻeha maʻi maʻi. He haʻahaʻa loa ke kumukūʻai hana o ka ʻaʻahu, a hiki ke hana ʻia kāna hana me ka ʻole o nā hoʻopukapuka nui - haʻi iā PAP, ka mea nāna i hana i ka lole, Prof. Janusz Rosiak.
ʻO ka ʻaʻahu no ka mālama ʻana i nā ʻeha maʻi maʻi i kēia manawa e pono ai ka hoʻomaka ʻana o nā hoʻokolohua preclinical a me nā hoʻokolohua lapaʻau, ʻo ia - ʻo Prof. Rosiak - ʻaʻole i kālā ʻia e ka mokuʻāina. ʻO ia ke kumu e makemake ai mākou e hui pū me nā ʻoihana makemake i ka hana ʻana o ia mau lole - ua hoʻohui ʻo ia.
I ka wā o ka mālama ʻana me ka lole hydrogel maʻamau i hana ʻia e like me ke ʻano o Rosiak, ua ʻike ʻia he hopena maikaʻi nō hoʻi ia i ka mālama ʻana i ka wāwae i kapa ʻia ʻo diabetic, akā ʻo ka hiki ke hoʻōla i kēia ʻano ʻeha me ka hoʻohana ʻana i ia lole. ma kahi o 50 pakeneka. - e like me nā ʻano lole ʻē aʻe i ʻike ʻia a hoʻohana ʻia ma ka honua.
Pili kēia i ke ʻano o nā ʻeha maʻi maʻi, no ka mea, ua ʻike ʻia lākou e, i waena o nā mea ʻē aʻe, necrosis o nā ʻiʻo ʻeha ma muli o ka pōʻino a me ka luku ʻana i nā kīʻaha koko. Hoʻopili pū ʻia me ka luku ʻana i ka ʻiʻo nerve a me ka make mālie o nā ʻiʻo e puni ana i ka ʻeha.
ʻO nā ho'āʻo e mālama i kēia ʻano ʻeha, i hana ʻia ma Polani a me ka honua holoʻokoʻa, e iho i lalo e ʻike i ke ʻano o nā maʻi bacterial a me ka hoʻohana ʻana i nā lāʻau antibiotic a i ʻole nā mea ikaika e hiki ke hoʻomaikaʻi i ka maʻemaʻe o ka ʻeha. ʻOiai e kali ana no ka hoʻōla ʻana o ka ʻeha, hiki ke hāʻawi ʻia i nā mea e hiki ai ke hoʻoulu i ka angiogenesis, ʻo ia hoʻi ka hoʻihoʻi ʻana a me ke kūkulu ʻana i nā kīʻaha koko hou i loko o ka ʻeha. No kēia kumu, ka hoʻohana ʻana i kekahi mau mea, ka mea i kapa ʻia nā kumu ulu.
Ua wehewehe ʻo Prof. Rosiak i kā lākou noiʻi ʻana, ua hālāwai nā ʻepekema mai Łódź i nā hōʻike i loko o ka puke e pili ana i ka hoʻohana ʻana i kahi tetrapeptide maʻalahi e hoʻowalewale i ka angiogenesis ma ka hāʻawi ʻana iā ia i ka wahi i mālama ʻia o ke kino. He hui ia i hana maoli ʻia i loko o ke kino o ke kanaka, me ka hapalua o ke ola pōkole o 5 mau minuke, no laila ʻoi loa ka haʻahaʻa o kona ʻike ʻana i kahi mea ola maʻamau. Ua hoʻopaʻa inoa ʻia kēia tetrapeptide ma ke ʻano he lāʻau lapaʻau a ʻae ʻia e ka US Food and Drug Administration (FDA).
Eia nō naʻe, ʻo kāna hoʻoponopono ʻana i nā ʻiʻo e hoʻopuni ana i ka ʻeha i hana ʻia e ka injection, kahi i hiki ʻole ai ke hoʻomalu i ka wahi o ka hana a hoʻoulu i nā hopena maʻamau - hiki koke i nā kiʻekiʻe kiʻekiʻe a me ka nalo wikiwiki ʻana, e luku ana i kāna hopena therapeutic. ʻO kā mākou kumu, ma ka honua holoʻokoʻa, hoʻomaka ka manaʻo i ka hoʻāʻo ʻana e hoʻohui i kahi lole hydrogel me kēia tetrapeptide - wehewehe ka ʻepekema.
ʻO ka ʻenehana o ka hana ʻana i kahi lole hydrogel i hoʻomohala ʻia e nā mea noiʻi ʻo Łódź, ʻo ia ka hana ʻana i ka hui ʻana o nā mea ʻaʻahu i loko o ka wai (ʻoi aku ka nui o ka wai ma mua o 90% o kāna hana ʻana), a laila ma hope o ka waiho ʻana i loko o ka ʻeke a pani ʻia, sterilizing me kahi uila uila. ʻO ka hopena, ua hoʻokumu ʻia kahi pāpale hydrogel sterile i hoʻohana ʻia ma ke ʻano he lole.
ʻO ka pilikia o ka noiʻi inā ʻaʻole e luku ʻia ka mea ikaika i ka wā sterilization, no ka mea, ʻo ka tetrapeptide i loko o ka wai wai ma lalo o ka mana o ka electron beam ua pau loa i ka luku ʻia i nā dose electron ʻaʻole i hōʻoia i ka sterility o ka huahana. Eia naʻe, hiki iā mākou ke hoʻoponopono i kēia pilikia - i hoʻohui ʻia e prof. Rosiaka.
Ua waiho ʻia ka hopena no ka pale ʻana ma ke Keʻena Patent. Mahalo i ke kākoʻo kālā o ka National Center for Research and Development, ua hana nā ʻepekema mai Lodz i ka noiʻi e pili ana i nā kinetics o ka hoʻokuʻu ʻana o ka tetrapeptide i loko o ka ʻeha, kona lōʻihi i ka lole (hiki ke hoʻohana ʻia i hoʻokahi makahiki ma hope o kāna hana ʻana) a ka launa pū me nā pūnaewele.
Ma ka pae mole, ua hōʻoia mākou i ka hōʻike o nā genes kuleana no ka angiogenesis, a ma ka pae cellular, kahi wikiwiki nui o ka hoʻonui ʻana o nā cell endothelial. Ua hōʻike pū mākou i ka hilinaʻi o nā hopena i loaʻa i ka neʻe ʻana o ka tetrapeptide a ua hoʻoholo mākou i ka dosage maikaʻi loa - i ʻōlelo ʻia e ke kauka.
Hoʻolaha ka poʻe ʻepekema inā ʻaʻole lākou e ʻike i kahi kumu kālā no ka noiʻi hou ʻana e pili ana i ka ʻaʻahu, ʻaʻole lākou e hōʻole e hoʻolaha lākou i ka ʻike o ko lākou manaʻo. ʻO ka pilikia o ka mālama ʻana i ka wāwae diabetic e pili ana i nā kānaka a puni ka honua a ʻaʻole pono mākou e loaʻa kālā ma luna o ia mea - manaʻoʻiʻo prof. Rosiaka. (PAP)