Hiki ke hoʻoholo ʻia ke ʻano o ka ʻakika uric i ke koko a i ka mimi paha. ʻO ka ʻoi aku ka nui, he hōʻailona ia o ka gout, ka inu ʻawaʻawa nui a i ʻole ka hōʻole ʻana o ka puʻupaʻa.

ʻO ka waika uric he a make o ke kino. ʻO ke kikoʻī, ʻo ia ka huahana hope o kakāpae nā molekala i kapa ʻia nā ʻakika nucleic a me nā purine.

ʻO ka mea maʻamau, hoʻoheheʻe ka hapa nui o ka uric acid i loko o ke kino o ke kanaka a komo i loko o nā puʻupaʻa no ka hoʻopau ʻana i ka mimi. Akā i kekahi mau hihia, hoʻopuka ke kino i ka waika uric keu a ʻaʻole hiki ke wehe i ka lawa. Hiki i kēia maʻi ke kumu o nā maʻi like ʻole.

ʻO ka waika uric ka hopena o ka hoʻohaʻahaʻa ʻana o lohi, ʻokoʻa kona helu ma muli o ka purine i loko o ke kino. A ua ʻike ʻia ka loaʻa ʻana o nā purine i ka meaʻai. 

ʻO kekahi o nā meaʻai kiʻekiʻe i ka purine e pale ʻia:

• nā anchovies, herring, mackerel, sardines, shrimps, etc;
• ke akepaʻa, ka puʻuwai, ka lolo, nā puʻupaʻa, ka berena ʻono, a pēlā aku;
• pī, pī maloʻo, etc.

ʻAʻole ʻōlelo ʻia ka ʻai ʻana i ka waiʻona, a me ka pia inā makemake ʻoe e hōʻemi i kāu ʻakika uric.

ʻO ka mea ʻē aʻe, ma waena o nā meaʻai i ʻae ʻia me ka haʻahaʻa o ka purine, hiki iā mākou ke haʻi:

• kī, kofe, nā mea inu ʻoluʻolu;
• nā huaʻai a me nā mea kanu;
• hua manu ;
• berena a me nā palaoa;
• paʻakai a ʻoi aku ka nui o nā huahana waiū

No ke aha e ho'āʻo ai i ka ʻakika uric?

Kauoha ke kauka i ka ho'āʻo koko (i kapa ʻia ʻo uricemia) a / a i ʻole ka hoʻāʻo ʻana i ka ʻakika urinary no:

• ʻike i ka gout;
• e nānā i ka maikaʻi o ka hana ʻana o nā puʻupaʻa;
• hiki ke noi i ka wā hāpai;
• a i ʻole i ka poʻe paona nui.

E hoʻomaopopo ʻo ka nānā ʻana i ka neʻe o ka uric acid i loko o ka mimi e hiki ai ke hoʻomaopopo maikaʻi i ke kumu o kahi kiʻekiʻe o ka uric acid i loko o ke koko.

I loko o ke koko, aia ka waiwai maʻamau o ka uric acid ma waena o 35 a me 70 mg / L.

Ua kapa ʻia kahi kiʻekiʻe o ka ʻakika uric i ke koko hyperuricemia a hiki ke kumu ma muli o ka hana nui ʻana o ka uric acid i loko o ke kino a i ʻole ka emi ʻana o kona hoʻopau ʻia e nā puʻupaʻa. No laila, ʻo nā kiʻekiʻe kiʻekiʻe o ka uric acid i loko o ke koko he hōʻailona o:

• gout (ʻo ia ke kumu nui o ka piʻi ʻana o ke kiʻekiʻe o ka waikawa uric i ke koko);
• ka nui o ka hoʻohaʻahaʻa ʻana o nā protein o ke kino i hana ʻia, no ka laʻana, i ka wā chemotherapy, leukemia a i ʻole lymphoma;
• ʻalekohola;
• hooikaika kino nui;
• ka hele ʻana o nā pōhaku ʻaʻai;
• ka pohō wikiwiki;
• maʻi diabet;
• he meaʻai nui i ka purine;
• preeclampsia i ka wā hāpai;
• a i ʻole ka maʻi kīkī.

ʻO ka mea ʻē aʻe, ʻoi aku ka haʻahaʻa o ke koko uric acid ma mua o ka mea maʻamau, akā ʻoi aku ka maʻamau o kēia ma mua o ke ʻano o ka hopena i kiʻekiʻe.

No laila, pili nā pae uric acid ma lalo o nā waiwai maʻamau i:

• ʻai haʻahaʻa purine;
• ʻO ka maʻi o Wilson (he maʻi genetic kahi e kūkulu ai ke keleawe i loko o ke kino);
• ʻōpū (e like me Fanconi syndrome) a i ʻole ka pōʻino o ka ate;
• a i ʻole ka ʻike ʻana i nā mea ʻawaʻawa (lead).

I ka mimi, ʻo ka waiwai maʻamau o ka uric acid ma waena o 250 a 750 mg / 24 mau hola.

E hoʻomaopopo he loli iki paha nā kumukūʻai maʻamau ma muli o nā hale hana e hana nei i nā anamanaʻo.

E pili ana i ka 5 a hiki i ka 15% o ka heluna kanaka, he mea maʻamau ka biochemical abnormality, ma muli o ka overproduction o ka uric acid a / a i ʻole ka hoʻemi ʻana i ka renal elimination. Hoʻoulu pinepine ia me ka ʻeha ʻole a no laila ʻaʻole ʻike koke ʻia.

Hiki ke wehewehe ʻia nā pae kiʻekiʻe o ka uric acid e:

Idiopathic a i ʻole hyperuricemia mua

Hōʻike lākou i ka hapa nui o nā hihia. Loaʻa nā predispositions hoʻoilina i ka 30% o nā kumuhana, akā pili pinepine lākou me ka momona, ka ʻai nui, ke koko kiʻekiʻe, ka inu ʻawaʻawa, ka maʻi diabetes a me ka hypertriglyceridemia.

Nā mea ʻino ʻole o ka enzyme

Loaʻa lākou i ka maʻi Von Gierke a me ka maʻi Lesch-Nyhan. ʻO kēia mau mea ʻino enzymatic ke kumu o ka hoʻouka ʻana i ka gout i ke kakahiaka nui, ʻo ia hoʻi i nā makahiki 20 mua o ke ola.

Hyperuricemia lua no ka maʻi a i ʻole ka lāʻau lapaʻau.

ʻO kēia hyperuricemia paha ma muli o:

- ka nele o ka wehe ʻana i ka waika uric. ʻO kēia ka hihia no ka hāʻule ʻana o ka kidney, akā ma muli o kekahi mau lāʻau (diuretics, akā, laxatives a me kekahi mau lāʻau anti-tuberculosis).

- ka piʻi ʻana o ka hoʻohaʻahaʻa ʻana o nā waikawa nucleic. ʻIke mākou i kēia i nā maʻi koko (leukemia, hemopathies, hemolytic anemia, extensive psoriasis), a me nā hopena o kekahi mau chemotherapies maʻi kanesa.

Nā hopena o ka hyperuricemia

Hiki i ka Hyperuricemia ke kumu i ʻelua ʻano pilikia:

• ʻO ka gout ke kuleana no ka ʻeha hui pū.

Ke hoʻoheheʻe ʻia nā microcrystals o ka ʻakika uric i loko o ke koko i kahi ʻano kiʻekiʻe loa a maikaʻi nā kūlana kūloko (ʻo ia hoʻi ka lawa o ka acidity o ka medium), e hoʻoheheʻe lākou a alakaʻi i ka mumū kūloko. Pili kēia i ka hui o ka manamana wāwae nui. ʻO 1 wale nō i ka 10 poʻe me ka nui o ka uric acid i loko o ko lākou koko e loaʻa i ka gout, no laila pono ʻoe i ka maʻalahi e loaʻa ia.

• ʻO ka lithiasis urinary.

No ka loaʻa ʻana o hoʻokahi a ʻoi aku paha nā pōhaku i loko o ka ʻāpana mimi a nona ke kuleana no ka colic renal. He maʻi maʻamau ka Urolithiasis mai ka 1 a 2% o ka heluna kanaka i hoʻopilikia ʻia ma Farani.

Hiki ke hoʻokō ʻia ka nānā ʻana o ke kiʻekiʻe o ka waikawa hoʻokahi i ke koko a / a i ʻole i ka mimi:

• ʻO ka hoʻāʻo ʻana i ke koko he laʻana o ke koko venous, maʻamau i ka ʻili o ka kuʻekuʻe;
• ana ke kiʻekiʻe o ka uric acid i loko o ka mimi ma mua o 24 mau hola: no ka hana ʻana i kēia, ua lawa ka mimi i loko o kahi pahu i hoʻolako ʻia no kēia kumu a hāʻawi ʻia e nā limahana lapaʻau no hoʻokahi lā a me hoʻokahi pō.

E hoʻomaopopo he mea pono ʻaʻole e ʻai a inu i kekahi mea i nā hola ma mua o ka hoʻāʻo.

Nui nā kumu e hoʻopilikia ai i ke kiʻekiʻe o ka waika uric i loko o ke koko a i ʻole ka mimi. Aia kēia mau mea:

• nā meaʻai (ʻilihune a kiʻekiʻe paha i ka purines);
• nā lāʻau (e hoʻopaʻa inoa i ka gout, aspirin, a i ʻole diuretics);
• makahiki, nā keiki me nā waiwai haʻahaʻa;
• ke kāne, me nā wāhine he haʻahaʻa ka helu ma mua o nā kāne;
• ke kaumaha, ka poʻe obese i ʻoi aku ka kiʻekiʻe.

ʻO nā lāʻau lapaʻau inā he hōʻailona ka hyperuremia penei: 

• Nucleic acid synthesis reducers, like allopurinol. Pono ʻoe e makaʻala loa no ka mea he nui nā pilina me nā lāʻau ʻē aʻe.
• ʻO nā lāʻau lapaʻau e kāohi ai i ka hoʻihoʻi ʻana o ka waika uric renal, e like me benzbromarone.
• ʻO nā lāʻau enzymatic e hoʻoulu pinepine ai i nā pilikia allergy.

ʻO nā mea a pau, ʻo ke kauka ka mea e hoʻoholo inā pono e hahai ʻia kahi lapaʻau, a ʻo ia ka mea kūpono.