Kakalaioa waiū (Silybum marianum) lawe ʻia kona inoa mai ka Virgin Mary. Wahi a ka moʻolelo, ʻoiai ʻo ia e hānai ana i kāna keiki ʻo Iesū ma kahi huakaʻi ma waena o ʻAigupita a me Palesetina, ua hoʻokahe ʻo Maria i kekahi mau kulu o kona waiū umauma ma luna o kahi kumulāʻau. No keia mau kulu i puka mai ai na aa keokeo o na lau o ka meakanu.

I loko o kāna hua, aia ka silymarin, kāna mea hana, i ʻike ʻia no kona hopena pale i ke ake. Hoʻolaha ia i kāna metabolism cellular ʻoiai e pale ana a pale iā ia mai ka pōʻino i hana ʻia e nā toxins kūlohelohe a i ʻole synthetic.

Ke Komisina¹a me ka WHO ike i ka hoʻohana 'ana i ka silymarin e mālama i ka hepatic poisoning (hoʻohana o ka extract standardized i 70% a 80% o ka silymarin) a me kona pono e kū'ē i nā maʻi ate e like me ka hepatitis a me ka cirrhosis, a me ka 'classic lapaʻau lapaʻau. I ka hoʻohana ʻana i kēlā me kēia lā, hoʻēmi ia i ka ulu ʻana o ka cirrhosis.

Hiki i kekahi poʻe ke pane i ka waiu kākalaio inā maʻi lākou i nā mea kanu e like me daisies, hōkū, chamomile, etc.

No nā maʻi o ka ate, ua ʻōlelo ʻia e lawe i ka extract standardized o ka waiū thistle (70% a 80% silymarin) ma ka helu o 140 mg a 210 mg, 3 mau manawa i ka lā.

ʻO nā lālā 24 o ke Komisina E he papa interdisciplinary kūʻokoʻa i loaʻa i nā loea i ʻike ʻia i ka lāʻau lapaʻau, pharmacology, toxicology, pharmacy and phytotherapy. Mai 1978 a i 1994, ua loiloi kēia mau loea i nā mea kanu 360 e pili ana i nā palapala nui e pili ana, ma waena o nā mea ʻē aʻe, nā loiloi kemika, nā hoʻokolohua, nā lāʻau lapaʻau a me nā haʻawina toxicological a me ka noiʻi lapaʻau a me ka epidemiological. Ua loiloi ʻia ka papa mua o ka monograph e nā lālā a pau o ke Komisina E, akā e nā hui ʻepekema, nā loea hoʻonaʻauao a me nā loea ʻē aʻe. ʻO ka lāʻau lapaʻau mai A a Z, olakino ma o nā mea kanu, p 31. Mālama iā ʻoe iho, alakaʻi kūpono, nā huahana olakino kūlohelohe, nā mea āpau e pono ai ʻoe e ʻike e hoʻohana maikaʻi ai, p36. Treatise on phytotherapy, kauka Jean-Michel Morel, paʻi ʻo Grancher.