ʻO ka uricemia ka paʻa ʻana o ka waika uric i loko o ke koko. ʻO kēia ʻakika uric ka hopena mai ka hoʻohaʻahaʻa ʻana i nā huahana nitrogenous, ma muli o ka catabolism o nā ʻakika nucleic i loaʻa i loko o ke kino (DNA a me RNA), a i ʻole ka luku ʻana i nā purines i komo i ka meaʻai. Hoʻopau mua ʻia ka ʻakika uric ma o ka mimi. ʻO ka piʻi ʻana o nā pae uric acid, i kapa ʻia ʻo hyperuricemia, hiki ke hopena i ka gout a i ʻole urolithiasis. ʻIke ʻia ka hypo-uricemia i kekahi manawa ma hope o ka lawe ʻana i kekahi mau lāʻau lapaʻau. ʻO ka lawe ʻana i nā ʻano ʻai maikaʻi e kōkua i ka mālama ʻana i ka uricemia pololei.

ʻO ka uricemia ke kiʻekiʻe o ka waika uric i ka plasma koko. He huahana kēia uric acid ma muli o ka hoʻohaʻahaʻa ʻia ʻana o nā huahana nitrogenous: no laila, ʻo ia ka hopena mai ka catabolism o nā waikawa nucleic i loko o ke kino ma ke ʻano o DNA a me RNA, a i hana ʻia e ka hoʻohaʻahaʻa ʻana o nā purine i ʻai ʻia i ka wā ʻai. No laila, ʻo ka ʻakika uric kahi ʻōpala i hana ʻia e ke kino, ʻoiai, i ka wā o ka make a me ka hana hou ʻana o ke kelepona, hoʻohaʻahaʻa ia i nā molekole DNA a me RNA (nā molekala e lawe i ka ʻike genetic o kēlā me kēia kanaka a ʻae i kāna unuhi ʻana i nā protein).

Loaʻa ka ʻakika uric i loko o ke koko, kahi i puʻunaue ʻia ma waena o ka plasma a me nā ʻāpana koko, a me nā ʻiʻo. ʻAʻole hiki ke hoʻololi ʻia ka ʻakika uric, e like me nā manu, i allantoin: ʻoiaʻiʻo, ʻaʻole i loaʻa i ke kanaka ka enzyme hiki ke hoʻopau i ka waika uric ma kēia ala o allantoin. No laila, e hoʻokuʻu ʻia kēia ʻakika uric, i loko o ke kanaka, ma o ka mimi.

• Inā kiʻekiʻe ka nui o ka ʻakika uric koko, hiki iā ia ke hōʻiliʻili i loko o nā ami a hoʻoulu i ka ʻeha e hoʻouka ai i ka gout, he ʻeha loa.
• Inā hōʻiliʻili ia i loko o ka ʻāpana urinary, hiki iā ia ke hoʻoulu i ka urolithiasis, a ma ke alo o nā pōhaku, e hōʻeha nui ai.

Pono e hana ʻia ka uricemia inā kānalua ke kauka i ka piʻi ʻana o ka waika uric i loko o ke koko. No laila, e hoʻokō pono ʻia kēia loiloi biological:

• inā kānalua ke kauka i kahi ʻano o ka gout, i ka wā e ʻeha ai ka mea maʻi;
• no ka nānā ʻana i kekahi mau maʻi i loaʻa ka hyperuricemia, e like me ka hōʻole ʻana o ke kīkī a i ʻole kekahi mau maʻi koko; 
• ma hope o ka lawe ʻana i kekahi mau lāʻau lapaʻau e like me ka diuretics e keʻakeʻa ana i ka hoʻopau ʻana o ka uric acid; 
• i ka hihia o ka ʻai nui, hiki ke hoʻonui i ke kiʻekiʻe o ka uric acid; 
• e nānā no ka hypo-uricemia;
• i ka wā hāpai, e ʻike i ka hyperuricemia;
• i loko o ka poʻe i loaʻa i nā pōhaku kīkī o ka ʻakika uric a i ʻole ka urate;
• no ka nānā ʻana i nā poʻe e hōʻike nei i kahi uricemia kiʻekiʻe, i mea e ʻike ai i nā pilikia o nā pilikia renal.

Hoʻohui pinepine ʻia kēia hoʻāʻo uric acid me ke aʻo ʻana i ka hana o ka puʻupaʻa, ma ke ana ʻana i ke kiʻekiʻe o ka creatinine i loko o ke koko.

Hoʻoholo ʻia ka biological o ka uric acid e kahi ʻenehana enzymatic, ma ka serum, ma hope o kahi hoʻāʻo koko. Lawe ʻia kēia laʻana koko mai ka mea maʻi hoʻokē ʻai, a ma waho o kahi ʻai i hoʻoinu ʻia. Hana ʻia ka venipuncture ma ka ʻili o ka kuʻekuʻe. Hana ʻia ia i loko o ke keʻena hoʻokolohua lāʻau lapaʻau, pinepine ma ke kūlanakauhale, ma hope o ke kau ʻana o ka lāʻau lapaʻau. Ma ka awelika, loaʻa nā hopena i loko o 24 mau hola o ka hōʻiliʻili.

Kaʻapuni ka ʻakika uric i ke koko ma nā pae maʻamau i nā wahine ma waena o 150 a 360 µmol no ka lita, a i nā kāne ma waena o 180 a me 420 µmol no ka lita. ʻO ke kiʻekiʻe maʻamau o nā pākeke, i ka mg o ka lita, ua manaʻo pinepine ʻia ma waena o 25 a 60 i nā wahine a me 35 a 70 i nā kāne. I nā keiki, pono ia ma waena o 20 a 50 mg no ka lita ('o ia ho'i, 120 a 300 µmol no ka lita).

I ka hopena o ka hyperuricemia, no laila me ka nui o ka waika uric ma mua o 360 µmol / lita i nā wahine a ʻoi aku hoʻi ma mua o 420 µmol / lita i nā kāne, hiki i ka mea maʻi ke loaʻa i ka gout a i ʻole urolithiasis.

• ʻO ka gout he maʻi hui pū ʻia, ka mea nui e pili ana i ka manamana wāwae nui, akā i kekahi manawa pū kekahi i nā hui kuʻekuʻe wāwae a me nā kuli. Ma muli o ka hoʻonui ʻia ʻana o ka ʻakika uric i loko o ke koko e alakaʻi ana i ka hōʻiliʻili ʻana i nā hui peripheral o nā kristal urate, a me ka mumū. Hoʻohana pinepine ʻia ka mālama ʻana i ka hoʻouka kaua ʻana i ka colchicine. Hiki ke pale ʻia ka Hyperuricemia ma ka wehe ʻana i nā kumu o ka hyperuricemia, a me nā mea hoʻopaneʻe xanthine oxidase (e hoʻololi kēia enzyme i kahi mole i kapa ʻia ʻo xanthine i ka waika uric).

   

• ʻO ka Urolithiasis ka hele ʻana o nā pōhaku ma ke ala o ka hoʻokuʻu ʻana i ka mimi, ma muli o ka hana ʻana o nā kristal.

ʻO ka Hypo-uricemia, ʻo ia hoʻi, ka nui o ka waika uric ma lalo o 150 µmol / lita i nā wahine a me 180 µmol / lita i nā kāne, ʻike nui ʻia i ka wā o ka mālama ʻana i ka urico-eliminating a i ʻole ka urico-braking.

I ka wā kahiko, ua hōʻike ʻia ka maʻi gout ma muli o ka ʻai nui ʻana a me ka inu ʻana. Akā i loko o nā makahiki he ʻumi i hala iho nei, ua ʻike ʻia ka ʻike ākea o nā mea ʻai e pili ana i ka hyperuricemia a me ka gout. No laila, pinepine, hāʻawi ka overfeeding i ka hoʻonui ʻana i ka uric acidemia o ke kauoha o 10 mg / ml. ʻOi aku ka nui, i nā kāne makua me ka uricaemia ma waena o 60 a me 70 mg / ml, hiki i kēia piʻi ke hōʻike i ka gout.

ʻO ka momona, ka ʻiʻo ʻulaʻula nui i loko o ka meaʻai a me nā mea inu ʻawaʻawa ua ʻike mua ʻia ma ke ʻano he kumu no ka gout, mai ka wā kahiko. Ma ka ʻaoʻao ʻē aʻe, ʻaʻole pili nā mea kanu a me nā mea kanu i waiwai i ka purine, e like me ka hōʻike ʻana o kekahi mau haʻawina. Ma ka ʻaoʻao ʻē aʻe, ua ʻike ʻia nā mea pilikia hou, ʻaʻole i ʻike ʻia, me ka fructose a me nā mea inu sugary. ʻO ka mea hope loa, ua hōʻike ʻia nā mea palekana, ʻo ia hoʻi ka ʻai ʻana i nā huahana waiū skimmed.

Hōʻike ʻia ka gout ʻaʻole wale i ka hoʻonui ʻia ʻana o ka uric acid, nā ʻāpana hiki ke o ka arthritis a me ka pōʻino mau, akā hiki ke pili pū me nā comorbidities koʻikoʻi, a me ka piʻi nui ʻana o ka maʻi cardiovascular. ʻO ka lawe ʻana i nā ʻano meaʻai olakino e kōkua i ka mālama maikaʻi ʻana i ka uricemia a hōʻemi i nā maʻi pili me ia.