ʻO ka huaʻōlelo "atherogenic" e pili ana i nā mea a i ʻole nā ​​mea i hiki ke hana i kahi atheroma, a i ʻole ka waiho ʻana o nā pā i hana ʻia e LDL-kolesterol, nā hunaola hoʻāhu a me ka pūpū fibrous. Kūpilikiʻi loa kēia hanana inā hoʻolako ke aʻa i kahi meaola nui e like me ka puʻuwai a i ʻole ka lolo. ʻO ia ke kumu o ka nui o nā maʻi maʻi maʻi, me ka hahau ʻana a me ka infoccial myocardial. ʻO kāna pale mua ka hoʻopili ʻana i ka hoʻomaʻemaʻe maikaʻi a me nā ʻano papaʻai. Hāʻawi ʻia ka pale kiʻekiʻe i nā maʻi i loaʻa i nā ʻōuli a i ʻole ka pilikia. I kēia hihia, ʻo ka pahuhopu e hōʻemi i ka makaʻu o kahi pilikia hou, ma ka ʻāina like a i ʻole ma kahi ʻāpana vascular ʻē aʻe.

ʻO ka huaʻōlelo "atherogenic" e pili ana i nā mea a i ʻole nā ​​mea i hiki ke hana i kahi atheroma, ʻo ia hoʻi kahi waiho o nā pā i hana ʻia me nā lipida, nā hunaola hoʻāhu, nā hunaola musone mālie a me nā mea hoʻopili. Hoʻopili kēia mau plake iā lākou iho i nā paia o loko o nā aʻa waena a me nā nui, i ka puʻuwai, ka lolo a me nā wāwae, a alakaʻi i kahi hoʻololi kūloko o ka hiʻohiʻona a me ke ʻano o kēia mau paia. 

Hiki i ka waiho ʻana o kēia mau plake ke alakaʻi i nā pilikia koʻikoʻi e like me ka maʻi o ke aʻa coronary ma o ke kumu ʻana:

• ka mānoanoa a me ka nalo ʻana o ka lahilahi o ka paia arterial (atherosclerosis);
• kahi hoʻemi i ke anawaena o ke aʻa (stenosis). Hiki i kēia hanana ke piʻi ma mua o 70% o ke anawaena o ke aʻa. Kapa ʻia kēia stenosis paʻa;
• paukū hapa a piha paha o ke aʻa (thrombosis).

'Lelo mākou e pili ana i ka papaʻai atherogenic e koho ai i kahi papaʻai momona i ka momona, e like me ka papaʻai Komohana i waiwai nui i ka momona momona a me nā trans fatty acid ma hope o ka hydrogenation o nā momona momona e ka hana ʻenehana.

ʻO ke kūkulu ʻana i nā plahes atheromatous ma muli o nā kumu he nui, akā ʻo ke kumu nui ʻoi aku ka nui o ka cholesterol i ke koko, a i ʻole hypercholesterolemia. ʻOiaʻiʻo, ʻo ka hoʻokumu ʻia ʻana o ka plaque atheromatous kaukaʻi ʻia i ke kaulike ma waena o kaʻai o ka cholesterol, ka pae o ka pae a me ka hoʻopau ʻana.

Ma loko o ke ola, hana kekahi mau ʻano hana i nā naha i ka paia arterial, ma nā wahi bifurcation:

• hypertension arterial a, me ka hoʻohui i kāna hana mechanical ma ka paia, hoʻololi i ke kahe intracellular o lipoproteins;
• nā mea vasomotor, e like me angiotensin a me catecholamines, ka mea e mālama i ka collage sub-endothelial;
• nā mea hypoxiant, e like me nikotine, ka mea e hoʻopilikia ai i ke kelepona hele a hiki i ka hoʻolaha ʻana o nā hui intercellular.

E ʻae kēia mau haki i ke ala i loko o ka paia arterial o nā lipoproteins liʻiliʻi e like me HDL (High Density Lipoprotein) a me LDL (Low Density Lipoprotein) lipoproteins. ʻO ka LDL-kolesterol, i kapa pinepine ʻia ma ke ʻano he "kolesterol maikaʻi", hiki i ke kahawai ke kūkulu. Pēlā e hana ai i nā leona mua, i kapa ʻia he lipid streaks. ʻO kēia nā waihona e hoʻāla i nā ala hele lipid ma ka paia o ka aʻa o loko. Ma ka liʻiliʻi, e hāwela ka LDL-kolesterol ma laila a lilo i mea hoʻowali no ka paia o loko. I mea e hoʻopau ai ia mea, kiʻi nā hope i nā macrophages i hoʻopili ʻia me LDL-cholesterol. Kaawale mai kekahi kaʻina hoʻokele, macrophages lilo i nui, make i ka apoptosis ʻoiai koe ka wahi paʻa. ʻAʻole hiki i nā ʻōnaehana maʻamau o ka hoʻopau ʻana o nā ʻōpala pūnaewele ke komo, hōʻiliʻili lākou i ka pahu atheroma e ulu mālie ana. I ka pane ʻana i kēia ʻano hana, neʻe nā hunaola mākala o ka paia vascular i loko o ka pā i kahi hoʻāʻo e hoʻokaʻawale i kēia puʻupuʻu puʻupuʻu inflammatory. E hana lākou i kahi screed fibrous i hana ʻia i nā olonā collagen: hana ka holoʻokoʻa i kahi pā ʻoi aku a ʻoi paha ka ʻoʻoleʻa a paʻa. Ma lalo o kekahi mau kūlana, hoʻopuka nā macrophages plaque i nā proteases hiki i ka digesting collagen i hana ʻia e nā ʻāpana puʻupuʻu puʻupuʻu. Ke lilo kēia hanana kūpilikiʻi i mea mau, hoʻonāukiuki ka hana o nā proteases ma nā olonā i ka refinement o ka screed e lilo i mea palupalu a hiki ke haki. I kēia hihia, naha paha ka paia o loko o ke aʻa. Hoʻohui ʻia nā platelet koko me nā ʻōpala o ke kelepona a me nā lipids i hōʻiliʻili ʻia i ka pā e hana i kahi ʻōpala, kahi e lohi ai a laila ālai i ke kahe o ke koko.

Hāʻawi ʻia ka kahe o ke kolamu i loko o ke kino e LDL a me HDL lipoproteins e halihali ana i ka cholesterol, mai ka meaʻai i ke koko, mai ka ʻōpū i ke ake a i ʻole nā ​​aʻa, a mai nā aʻa i ke ake. ʻO kēia ke kumu, ke makemake mākou e loiloi i ka atherogenike pilikia, hoʻopili mākou i kēia mau lipoproteins a hoʻohālikelike i kā lākou nui.

• Inā nui nā lipoproteins LDL, e halihali i ka cholesterol i nā aʻa, kiʻekiʻe ka makaʻi. ʻO kēia ke kumu i kapa ʻia ai ʻo LDL-cholesterol atherogenic;
• Hoʻoemi ʻia kēia makaʻi ke kiʻekiʻe ke kiʻekiʻe o ke koko o HDL lipoproteins, kahi e hōʻoia ai i ka hoʻihoʻi ʻia ʻana o ka cholesterol i ke akepaʻa kahi e hana ʻia ai ma mua o ka hoʻopau ʻia ʻana. No laila, ua kūpono ʻo HDL-HDL-cholesterol ma ke ʻano he cardioprotective ke kiʻekiʻe ke kiʻekiʻe, a ma ke ʻano he kūlana maʻi puʻuwai ke haʻahaʻa ka pae.

Hiki i ka mānoanoa o nā plaque atheromatous ke hoʻopili iki i ke kahe o ke koko a alakaʻi i ke ʻano o nā ʻōuli kūloko.

• ʻeha;
• nā mea nui;
• pokole o ka hanu;
• ke kūlana ʻole ke hele wāwae, etc.

Kū mai nā pilikia koʻikoʻi o ka atherosclerosis mai ka haki ʻana o nā plaque atherosclerotic, e hopena ana i ka hoʻokumu ʻia ʻana o kahi ʻōpala a thrombus paha, kahi e ālai ai i ke kahe o ke koko a hana i ka ischemia, nā hopena e hiki ke koʻikoʻi a make paha. Hiki ke hoʻopili ʻia nā aʻa o nā mea ʻokoʻa:

• maʻi coronary artery, i ka puʻuwai, me ka angina a i ʻole angina pectoris ma ke ʻano he hōʻailona, ​​a me kahi pōpilikia o ka infoccial myocardial;
• carotids, i ka ʻāʻī, me ka makaʻu o ka ulia pōpilikia cerebrovascular (hahau);
• ka aorta ʻōpū, ma lalo o ka diaphragm, me ka makaʻu o ka haki aneurysm;
• nā aʻa digestive, i loko o ka ʻōpū, me ka makaʻu o ka mesenteric infarction;
• nā aʻa o ke koʻokoʻo, ma ka pae o ka hakuʻala, me ka makaʻu o ka hōʻeha puʻuwai;
• nā aʻa o nā lālā lalo me kahi ʻōuli o ka limping o nā lālā lalo.

Ma waho o ka hoʻoilina, ka moekolohe a me ka makahiki, ʻo ka pale ʻana i ka hoʻokumu ʻia ʻana o nā plaque atheromatous e pili ana i ka hoʻoponopono ʻana o nā pilikia pilikia o ka maʻi puʻuwai.

• ka mālama kaumaha, ke koko kiʻekiʻe a me ka maʻi kō;
• hoʻōki puhipaka;
• ka hoʻoikaika kino maʻamau;
• ka lawe ʻana i nā ʻano hana olakino olakino;
• ka palena o ka inu lama ʻana;
• ka hoʻokele koʻikoʻi, etc.

Ke waiwai ʻole ka pā atheromatous a ʻaʻole i hopena i kahi hopena, lawa paha kēia pale mua. Inā kū ʻole kēia mau hana mua, ke ulu ka pālaki, e pono paha i ka lāʻau lapaʻau. Hiki iā ia ke kuhikuhi pololei ʻia inā nui ka pilikia o nā pilikia. Paipai ʻōnaehana ia no ka pale ʻana i ke kula kiʻekiʻe ma hope o ka hanana maʻi maʻi maʻi mua. Hoʻopili kēia lāʻau lapaʻau:

• nā lāʻau antiplatelet, e like me ka aspirin i nā kaha liʻiliʻi, e lahilahi i ke koko;
• nā lāʻau hoʻohaʻahaʻa lipid (statins, fibrates, ezetimibe, cholestyramine, hoʻokahi a i ʻole hui pū ʻia) me nā pahuhopu o ka hōʻemi ʻana i nā pae kolesterol maikaʻi, normalizing pae kolesterol a me ka stabilizing atheromatous plaques.

Kū me nā plaque atheromatous holomua me ka stenosis paʻa, e noʻonoʻo ʻia ka revascularization e ka angioplasty coronary. ʻAe kēia e hoʻonui i ka zona atheromatous mahalo i kahi balloon hoʻonui ma ka paena i ke aʻa koko me ka ischemia. I mea e hoʻomau ai i ka wehe a hoʻihoʻi i ke kahe o ke koko, hoʻonoho ʻia kahi mea mīkini liʻiliʻi i kapa ʻia he stent a waiho ʻia ma kahi.